Faculty of Biological Sciences

Dr Sylvain Gigout

PhD - France January 2006
Research Fellow
School of Biomedical Sciences

Contact:  Garstang 5.55, +44 (0)113 34 35510, email address for  

Chen K, Marsh BC, Cowan M, Al'Joboori YD, Gigout S, Smith CC, Messenger N, Gamper N, Schwab ME, Ichiyama RM Sequential therapy of anti-Nogo-A antibody treatment and treadmill training leads to cumulative improvements after spinal cord injury in rats Experimental Neurology 292 135-144, 2017
DOI:10.1016/j.expneurol.2017.03.012
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Du X, Hao H, Yang Y, Huang S, Wang C, Gigout S, Ramli R, Li X, Jaworska E, Edwards I, Deuchars J, Yanagawa Y, Qi J, Guan B, Jaffe DB, Zhang H, Gamper N Local GABAergic signaling within sensory ganglia controls peripheral nociceptive transmission Journal of Clinical Investigation 127 1741-1756, 2017
DOI:10.1172/JCI86812
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Gigout S, Deisz RA, Dehnicke C, Turak B, Devaux B, Pumain R, Louvel J Role of gap junctions on synchronization in human neocortical networks. Brain Res 1637 14-21, 2016
DOI:10.1016/j.brainres.2016.02.005
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Gigout S, Wierschke S, Dehnicke C, Deisz RA Different pharmacology of N-desmethylclozapine at human and rat M<inf>2</inf>and M<inf>4</inf>mAChRs in neocortex Naunyn-Schmiedeberg's Archives of Pharmacology 388 487-496, 2015
DOI:10.1007/s00210-014-1080-3
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Gigout S, Louvel J, Pumain R Decrease of neocortical paired-pulse depression in GAERS and possible implication of gap junctions Neuroscience Letters 584 302-307, 2015
DOI:10.1016/j.neulet.2014.10.047
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Du X, Hao H, Gigout S, Huang D, Yang Y, Li L, Wang C, Sundt D, Jaffe DB, Zhang H, Gamper N Control of somatic membrane potential in nociceptive neurons and its implications for peripheral nociceptive transmission. Pain 155 2306-2322, 2014
DOI:10.1016/j.pain.2014.08.025
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Gigout S, Louvel J, Rinaldi D, Martin B, Pumain R Thalamocortical relationships and network synchronization in a new genetic model "in mirror" for absence epilepsy Brain Research 1525 39-52, 2013
DOI:10.1016/j.brainres.2013.05.044
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Gigout S, Louvel J, Rinaldi D, Martin B, Pumain R Thalamocortical relationships and network synchronization in a new genetic model "in mirror" for absence epilepsy. Brain Res 1525 39-52, 2013
DOI:10.1016/j.brainres.2013.05.044
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Pettinger L, Gigout S, Linley JE, Gamper N Bradykinin controls pool size of sensory neurons expressing functionalδ-opioid receptors. J Neurosci 33 10762-10771, 2013
DOI:10.1523/JNEUROSCI.0123-13.2013
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Ooi L, Gigout S, Pettinger L, Gamper N Triple cysteine module within M-type K+ channels mediates reciprocal channel modulation by nitric oxide and reactive oxygen species. J Neurosci 33 6041-6046, 2013
DOI:10.1523/JNEUROSCI.4275-12.2013
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Rose KE, Gigout S, Gamper N M-Current Recording from Acute DRG Slices. Methods Mol Biol 998 311-320, 2013
DOI:10.1007/978-1-62703-351-0_25
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Gigout S, Wierschke S, Lehmann TN, Horn P, Dehnicke C, Deisz RA Muscarinic acetylcholine receptor-mediated effects in slices from human epileptogenic cortex Neuroscience 223 399-411, 2012
DOI:10.1016/j.neuroscience.2012.07.044
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Gigout S, Jones GA, Wierschke S, Davies CH, Watson JM, Deisz RA Distinct muscarinic acetylcholine receptor subtypes mediate pre- and postsynaptic effects in rat neocortex. BMC Neurosci 13 42-, 2012
DOI:10.1186/1471-2202-13-42
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Wierschke S, Gigout S, Horn P, Lehmann T-N, Dehnicke C, Bräuer AU, Deisz RA Evaluating reference genes to normalize gene expression in human epileptogenic brain tissues. Biochem Biophys Res Commun 403 385-390, 2010
DOI:10.1016/j.bbrc.2010.10.138
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Thomas DR, Dada A, Jones GA, Deisz RA, Gigout S, Langmead CJ, Werry TD, Hendry N, Hagan JJ, Davies CH, Watson JM N-desmethylclozapine (NDMC) is an antagonist at the human native muscarinic M(1) receptor. Neuropharmacology 58 1206-1214, 2010
DOI:10.1016/j.neuropharm.2010.02.017
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Louvel J, Gigout S, Armand V, Laschet J, Pumain R, Devaux B, Turak B, Olivier A, Avoli M Hyper-synchrony in focal cortical dysplasia EPILEPSIES 21 63-70, 2009
DOI:10.1684/epi.2009.0216

Laschet J, Louvel J, Kurcewicz I, Gigout S, Trottier S, Devaux B, Turak B, Pumain R [Cellular mechanisms of the epilepsies: In vitro studies on human tissue]. Neurochirurgie 54 141-147, 2008
DOI:10.1016/j.neuchi.2008.02.003
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Laschet JJ, Kurcewicz I, Minier F, Trottier S, Khallou-Laschet J, Louvel J, Gigout S, Turak B, Biraben A, Scarabin J-M, Devaux B, Chauvel P, Pumain R Dysfunction of GABAA receptor glycolysis-dependent modulation in human partial epilepsy. Proc Natl Acad Sci U S A 104 3472-3477, 2007
DOI:10.1073/pnas.0606451104
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Gigout S, Louvel J, Kawasaki H, D'Antuono M, Armand V, Kurcewicz I, Olivier A, Laschet J, Turak B, Devaux B, Pumain R, Avoli M Effects of gap junction blockers on human neocortical synchronization. Neurobiol Dis 22 496-508, 2006
DOI:10.1016/j.nbd.2005.12.011
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Gigout S, Louvel J, Pumain R Effects in vitro and in vivo of a gap junction blocker on epileptiform activities in a genetic model of absence epilepsy. Epilepsy Res 69 15-29, 2006
DOI:10.1016/j.eplepsyres.2005.12.002
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Gigout S, Louvel J, Pumain R Study of the efficacy of thalamo-cortical and cortico-thalamic relationships in a genetic model of absence-epilepsy (GAERS) Epilepsies 17 73-81, 2005
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Gigout S, Louvel J, Pumain R Antiepileptic effect of a gap junction blocker in a model of absence epilepsy, 2005

Louvel J, Gigout S, Kawasaki H, D'Antuono M, Armand V, Kurcewicz I, Turak B, Devaux B, Pumain R, Avoli A Role of gap junctions in human neocortical network synchronization, 2005

Vanni-Mercier G, Gigout S, Debilly G, Lin JS Waking selective neurons in the posterior hypothalamus and their response to histamine H3-receptor ligands: an electrophsiological study in freely moving cats (vol 144, pg 227, 2003) BEHAV BRAIN RES 152 163-163, 2004
DOI:10.1016/j.bbr.2004.02.004

Vanni-Mercier G, Gigout S, Debilly G, Lin JS Waking selective neurons in the posterior hypothalamus and their response to histamine H3-receptor ligands: an electrophysiological study in freely moving cats. Behav Brain Res 144 227-241, 2003
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