Faculty of Biological Sciences

Dr James Duce

Lecturer in Neuroscience
School of Biomedical Sciences

Contact:  Garstang 6.41b, +44(0) 113 34 33075, email address for  

Faculty Research and Innovation

Modules managed

BMSC2235 - Molecular Neuroscience

Modules taught

BIOL2211 - Human Diseases
BIOL5171M - Infectious & Non-infectious Diseases
BIOL5294M - MSc Bioscience Research Project Proposal
BIOL5392M - Bioscience MSc Research Project
BMSC1213 - Basic Laboratory and Scientific Skills 2
BMSC2231 - Topics in Neuroscience
BMSC2235 - Molecular Neuroscience
BMSC3143/44/45/46/BIOC3111/12/BIOL3112 - ATU - Neurodegeneration
BMSC3301 - Research Project in Biomedical Sciences
BMSC5382M - Extended Research Project
MICR2120/BIOC2301 - Integrated Biochemistry/Medical Bacteriology

Group Leader Dr James Duce  (Lecturer in Neuroscience)

Postgraduates

Andrew Tsatsanis (Primary supervisor) 50% FTE

Laloux C, Gouel F, Lachaud C, Timmerman K, Do Van B, Jonneaux A, Petrault M, Garcon G, Rouaix N, Moreau C, Bordet R, Duce JA, Devedjian JC, Devos D Continuous cerebroventricular administration of dopamine: A new treatment for severe dyskinesia in Parkinson's disease? Neurobiology of Disease 103 24-31, 2017
DOI:10.1016/j.nbd.2017.03.013
View abstract

Duce JA, Wong BX, Durham H, Devedjian JC, Smith DP, Devos D Post translational changes toα-synuclein control iron and dopamine trafficking; a concept for neuron vulnerability in Parkinson’s disease Molecular Neurodegeneration 12 -, 2017
DOI:10.1186/s13024-017-0186-8
View abstract

Lam LQ, Wong BX, Frugier T, Li QX, Collins SJ, Bush AI, Crack PJ, Duce JA Oxidation of Iron under Physiologically Relevant Conditions in Biological Fluids from Healthy and Alzheimer's Disease Subjects ACS Chemical Neuroscience 8 731-736, 2017
DOI:10.1021/acschemneuro.6b00411
View abstract

Lei P, Ayton S, Appukuttan AT, Moon S, Duce JA, Volitakis I, Cherny R, Wood SJ, Greenough M, Berger G, Pantelis C, McGorry P, Yung A, Finkelstein DI, Bush AI Lithium suppression of tau induces brain iron accumulation and neurodegeneration Molecular Psychiatry 22 396-406, 2017
DOI:10.1038/mp.2016.96
View abstract

Wong BX, Lam LQ, Tsatsanis A, Duce JA Evaluating iron flux in the brain, 2017
DOI:10.1007/978-1-4939-6918-0_10
View abstract

Poujois A, Devedjian JC, Moreau C, Devos D, Chaine P, Woimant F, Duce JA Bioavailable Trace Metals in Neurological Diseases Current Treatment Options in Neurology 18 -, 2016
DOI:10.1007/s11940-016-0426-1
View abstract

Gunn AP, Wong XBX, Johanssen XT, Griffith XJC, Masters CL, Bush AI, Barnham KJ, Duce JA, Cherny RA Amyloid- Peptide A-3pE-42 Induces Lipid Peroxidation, Membrane Permeabilization, and Calcium Influx in Neurons Journal of Biological Chemistry 291 6134-6145, 2016
DOI:10.1074/jbc.M115.655183
View abstract

Duce J, Wong B, Tsatsanis A, Lam L, Ayton S, Adlard P, Bush A The influence of amyloid-beta precursor protein proteolytic processing on neuronal iron homeostasis, 2015

Wong B, Bush A, Duce J Characterizing how post translational modifications can alter the serine protease inhibition of the KPI domain in app, 2015

Workman DG, Tsatsanis A, Lewis FW, Boyle JP, Mousadoust M, Hettiarachchi NT, Hunter M, Peers CS, Tétard D, Duce JA Protection from neurodegeneration in the 6-hydroxydopamine (6-OHDA) model of Parkinson's with novel 1-hydroxypyridin-2-one metal chelators Metallomics 7 867-876, 2015
DOI:10.1039/c4mt00326h
View abstract

Ayton S, Lei P, Hare DJ, Duce JA, George JL, Adlard PA, McLean C, Rogers JT, Cherny RA, Finkelstein DI, Bush AI Parkinson’s disease iron deposition caused by nitric oxide- induced loss of β-amyloid precursor protein Journal of Neuroscience 35 3591-3597, 2015
DOI:10.1523/JNEUROSCI.3439-14.2015
View abstract

Wong BX, Tsatsanis A, Lim LQ, Adlard PA, Bush AI, Duce JA β-amyloid precursor protein does not possess ferroxidase activity but does stabilize the cell surface ferrous iron exporter ferroportin PLoS ONE 9 -, 2014
DOI:10.1371/journal.pone.0114174
View abstract

Wong BX, Ayton S, Lam LQ, Lei P, Adlard PA, Bush AI, Duce JA A comparison of ceruloplasmin to biological polyanions in promoting the oxidation of Fe(2+) under physiologically relevant conditions. Biochim Biophys Acta 1840 3299-3310, 2014
DOI:10.1016/j.bbagen.2014.08.006
View abstract

Roberts BR, Lim NKH, McAllum EJ, Donnelly PS, Hare DJ, Doble PA, Turner BJ, Price KA, Lim SC, Paterson BM, Hickey JL, Rhoads TW, Williams JR, Kanninen KM, Hung LW, Liddell JR, Grubman A, Monty J-F, Llanos RM, Kramer DR, Mercer JFB, Bush AI, Masters CL, Duce JA, Li Q-X, Beckman JS, Barnham KJ, White AR, Crouch PJ Oral treatment with Cu(II)(atsm) increases mutant SOD1 in vivo but protects motor neurons and improves the phenotype of a transgenic mouse model of amyotrophic lateral sclerosis. J Neurosci 34 8021-8031, 2014
DOI:10.1523/JNEUROSCI.4196-13.2014
View abstract

Ayton S, Zhang M, Roberts BR, Lam LQ, Lind M, McLean C, Bush AI, Frugier T, Crack PJ, Duce JA Ceruloplasmin andβ-amyloid precursor protein confer neuroprotection in traumatic brain injury and lower neuronal iron. Free Radic Biol Med 69 331-337, 2014
DOI:10.1016/j.freeradbiomed.2014.01.041
View abstract

Wong BX, Duce JA The iron regulatory capability of the major protein participants in prevalent neurodegenerative disorders. Front Pharmacol 5 81-, 2014
DOI:10.3389/fphar.2014.00081
View abstract

Wong BX, Hung YH, Bush AI, Duce JA Metals and cholesterol: two sides of the same coin in Alzheimer's disease pathology. Front Aging Neurosci 6 91-, 2014
DOI:10.3389/fnagi.2014.00091
View abstract

Chen J, Marks E, Lai B, Zhang Z, Duce JA, Lam LQ, Volitakis I, Bush AI, Hersch S, Fox JH Iron Accumulates in Huntington's Disease Neurons: Protection by Deferoxamine PLoS ONE 8 -, 2013
DOI:10.1371/journal.pone.0077023
View abstract

Duce J, Lei P, Tsatsanis A, Wong B, Lam L, Ayton S, Rogers J, Finkelstein D, Bush A A NOVEL RELATIONSHIP BETWEEN beta-AMYLOID PROTEIN PRECURSOR AND TAU IN ALZHEIMER'S DISEASE RELATED IRON DISRUPTION AMERICAN JOURNAL OF HEMATOLOGY 88 E34-E35, 2013

Wong B, Lam L, Ayton S, Lei P, Gunn A, Bush A, Duce J NEW DEVELOPMENTS IN MEASURING THE ENZYMATIC ACTIVITY OF AMYLOID-beta PRECURSOR PROTEIN AND OTHER FERROXIDASES AMERICAN JOURNAL OF HEMATOLOGY 88 E191-E191, 2013

Ayton S, Lei P, Duce JA, Wong BXW, Sedjahtera A, Adlard PA, Bush AI, Finkelstein DI Ceruloplasmin dysfunction and therapeutic potential for Parkinson disease Annals of Neurology 73 554-559, 2013
DOI:10.1002/ana.23817
View abstract

Duce JA, Ayton S, Miller AA, Tsatsanis A, Lam LQ, Leone L, Corbin JE, Butzkueven H, Kilpatrick TJ, Rogers JT, Barnham KJ, Finkelstein DI, Bush AI Amine oxidase activity ofβ-amyloid precursor protein modulates systemic and local catecholamine levels. Mol Psychiatry 18 245-254, 2013
DOI:10.1038/mp.2011.168
View abstract

Gu BJ, Duce JA, Valova VA, Wong B, Bush AI, Petrou S, Wiley JS P2X7 receptor-mediated scavenger activity of mononuclear phagocytes toward non-opsonized particles and apoptotic cells is inhibited by serum glycoproteins but remains active in cerebrospinal fluid. J Biol Chem 287 17318-17330, 2012
DOI:10.1074/jbc.M112.340885
View abstract

Lei P, Ayton S, Finkelstein DI, Spoerri L, Ciccotosto GD, Wright DK, Wong BXW, Adlard PA, Cherny RA, Lam LQ, Roberts BR, Volitakis I, Egan GF, McLean CA, Cappai R, Duce JA, Bush AI Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export. Nat Med 18 291-295, 2012
DOI:10.1038/nm.2613
View abstract

James SA, Volitakis I, Adlard PA, Duce JA, Masters CL, Cherny RA, Bush AI Elevated labile Cu is associated with oxidative pathology in Alzheimer disease. Free Radic Biol Med 52 298-302, 2012
DOI:10.1016/j.freeradbiomed.2011.10.446
View abstract

Roberts BR, Ryan TM, Bush AI, Masters CL, Duce JA The role of metallobiology and amyloid-β peptides in Alzheimer's disease. J Neurochem 120 Suppl 1 149-166, 2012
DOI:10.1111/j.1471-4159.2011.07500.x
View abstract

Soon CPW, Donnelly PS, Turner BJ, Hung LW, Crouch PJ, Sherratt NA, Tan J-L, Lim NK-H, Lam L, Bica L, Lim S, Hickey JL, Morizzi J, Powell A, Finkelstein DI, Culvenor JG, Masters CL, Duce J, White AR, Barnham KJ, Li Q-X Diacetylbis(N(4)-methylthiosemicarbazonato) copper(II) (CuII(atsm)) protects against peroxynitrite-induced nitrosative damage and prolongs survival in amyotrophic lateral sclerosis mouse model. J Biol Chem 286 44035-44044, 2011
DOI:10.1074/jbc.M111.274407
View abstract

Duce JA, Bush AI, Adlard PA Role of amyloid-β-metal interactions in Alzheimers disease Future Neurology 6 641-659, 2011
DOI:10.2217/fnl.11.43
View abstract

Rembach A, Duce JA, O'Sullivan LA, Tanzi RE, Bush AI Biological Metals: Metallostasis and Alzheimer's Disease NEURODEGENERATION: METALLOSTASIS AND PROTEOSTASIS 152-173, 2011
DOI:10.1039/9781849733014-00152

Duce JA, Tsatsanis A, Cater MA, James SA, Robb E, Wikhe K, Leong SL, Perez K, Johanssen T, Greenough MA, Cho H-H, Galatis D, Moir RD, Masters CL, McLean C, Tanzi RE, Cappai R, Barnham KJ, Ciccotosto GD, Rogers JT, Bush AI Iron-export ferroxidase activity ofβ-amyloid precursor protein is inhibited by zinc in Alzheimer's disease. Cell 142 857-867, 2010
DOI:10.1016/j.cell.2010.08.014
View abstract

Duce JA, Bush AI Biological metals and Alzheimer's disease: Implications for therapeutics and diagnostics PROGRESS IN NEUROBIOLOGY 92 1-18, 2010
DOI:10.1016/j.pneurobio.2010.04.003

Perreau VM, Orchard S, Adlard PA, Bellingham SA, Cappai R, Ciccotosto GD, Cowie TF, Crouch PJ, Duce JA, Evin G, Faux NG, Hill AF, Hung YH, James SA, Li Q-X, Mok SS, Tew DJ, White AR, Bush AI, Hermjakob H, Masters CL A domain level interaction network of amyloid precursor protein and Abeta of Alzheimer's disease. Proteomics 10 2377-2395, 2010
DOI:10.1002/pmic.200900773
View abstract

Duce JA, Podvin S, Hollander W, Kipling D, Rosene DL, Abraham CR Gene profile analysis implicates Klotho as an important contributor to aging changes in brain white matter of the rhesus monkey. Glia 56 106-117, 2008
DOI:10.1002/glia.20593
View abstract

Crouch PJ, Cimdins K, Duce JA, Bush AI, Trounce IA Mitochondria in aging and Alzheimer's disease. Rejuvenation research 10 349-357, 2007
DOI:10.1089/rej.2007.0592
View abstract

Tripanichkul W, Sripanichkulchai K, Duce JA, Finkelstein DI 17Beta-estradiol reduces nitrotyrosine immunoreactivity and increases SOD1 and SOD2 immunoreactivity in nigral neurons in male mice following MPTP insult. Brain research 1164 24-31, 2007
DOI:10.1016/j.brainres.2007.05.076
View abstract

Watanabe S, Nagano S, Duce J, Kiaei M, Li QX, Tucker SM, Tiwari A, Brown RH, Beal MF, Hayward LJ, Culotta VC, Yoshihara S, Sakoda S, Bush AI Increased affinity for copper mediated by cysteine 111 in forms of mutant superoxide dismutase 1 linked to amyotrophic lateral sclerosis. Free radical biology&medicine 42 1534-1542, 2007
DOI:10.1016/j.freeradbiomed.2007.02.004
View abstract

Crouch PJ, Barnham KJ, Duce JA, Blake RE, Masters CL, Trounce IA Copper-dependent inhibition of cytochrome c oxidase by Abeta(1-42) requires reduced methionine at residue 35 of the Abeta peptide. Journal of neurochemistry 99 226-236, 2006
DOI:10.1111/j.1471-4159.2006.04050.x
View abstract

Duce JA, Smith DP, Blake RE, Crouch PJ, Li QX, Masters CL, Trounce IA Linker histone H1 binds to disease associated amyloid-like fibrils. Journal of molecular biology 361 493-505, 2006
DOI:10.1016/j.jmb.2006.06.038
View abstract

Duce JA, Hollander W, Jaffe R, Abraham CR Activation of early components of complement targets myelin and oligodendrocytes in the aged rhesus monkey brain. Neurobiology of aging 27 633-644, 2006
DOI:10.1016/j.neurobiolaging.2005.03.027
View abstract

Crouch PJ, Blake R, Duce JA, Ciccotosto GD, Li QX, Barnham KJ, Curtain CC, Cherny RA, Cappai R, Dyrks T, Masters CL, Trounce IA Copper-dependent inhibition of human cytochrome c oxidase by a dimeric conformer of amyloid-beta1-42. The Journal of neuroscience : the official journal of the Society for Neuroscience 25 672-679, 2005
DOI:10.1523/jneurosci.4276-04.2005
View abstract

Hinman JD, Duce JA, Siman RA, Hollander W, Abraham CR Activation of calpain-1 in myelin and microglia in the white matter of the aged rhesus monkey. Journal of neurochemistry 89 430-441, 2004
DOI:10.1046/j.1471-4159.2004.02348.x
View abstract

Boutell JM, Thomas P, Neal JW, Weston VJ, Duce J, Harper PS, Jones AL Aberrant interactions of transcriptional repressor proteins with the Huntington's disease gene product, huntingtin. Human molecular genetics 8 1647-1655, 1999
DOI:10.1093/hmg/8.9.1647
View abstract