Faculty of Biological Sciences

Dr Dan Donnelly

BSc, Leicester; PhD 1992, London.
Senior Lecturer
School of Biomedical Sciences

Contact:  Garstang 6.41d | +44(0) 113 34 37761 | email address for Dr Dan Donnelly 

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Admin roles

FBS FTSEC
FBS UGTSEC
Library Representative
UG Programme Leader: Pharmacology

Modules managed

BMSC2224 - Principles of Drug Discovery
BMSC3143 - Advanced Topics in Pharmacology I
BMSC3233 - Advanced Topics in Pharmacology II

Modules taught

BIOC3221/22/23/BIOL3210/BMSC3233/34/35/36 - ATU 23 - Membrane proteins
BMSC1212 - Introduction to Pharmacology
BMSC1213 - Basic Laboratory and Scientific Skills 2
BMSC2119 - Experimental Skills
BMSC2119/3302 - Experimental Skills/Medical Pharmacology
BMSC2224 - Principles of Drug Discovery
BMSC2230 - Topics in Pharmacology
BMSC3143 - Advanced Topics in Pharmacology I
BMSC3143/44/45/46 - ATUs - BMS specific
BMSC3301 - Research Proj: Biomed Sciences

Committees

Member of Undergraduate School Taught Student Education Committee

Group Leader Dr Dan Donnelly  (Senior Lecturer)

G Protein-Coupled Receptor - structure and function. 


Donnelly D The structure and function of the glucagon-like peptide-1 receptor and its ligands. Br J Pharmacol 166 27-41, 2012
DOI:10.1111/j.1476-5381.2011.01687.x
View abstract

Barwell J; Miller PS; Donnelly D; Poyner DR Mapping interaction sites within the N-terminus of the calcitonin gene-related peptide receptor; the role of residues 23-60 of the calcitonin receptor-like receptor PEPTIDES 31 170-176, 2010
DOI:10.1016/j.peptides.2009.10.021

Mann RJ; Nasr NE; Sinfield JK; Paci E; Donnelly D The major determinant of exendin-4/glucagon-like peptide 1 differential affinity at the rat glucagon-like peptide 1 receptor N-terminal domain is a hydrogen bond from SER-32 of exendin-4 BRIT J PHARMACOL 160 1973-1984, 2010
DOI:10.1111/j.1476-5381.2010.00834.x

Chapman KL; Kinsella GK; Cox A; Donnelly D; Findlay JBC Interactions of the Melanocortin-4 Receptor with the Peptide Agonist NDP-MSH J MOL BIOL 401 433-450, 2010
DOI:10.1016/j.jmb.2010.06.028

Miller PS; Barwell J; Poyner DR; Wigglesworth MJ; Garland SL; Donnelly D Non-peptidic antagonists of the CGRP receptor, BIBN4096BS and MK-0974, interact with the calcitonin receptor-like receptor via methionine-42 and RAMP1 via tryptophan-74 BIOCHEM BIOPH RES CO 391 437-442, 2010
DOI:10.1016/j.bbrc.2009.11.076

Mann RJ; Al-Sabah S; de Maturana RL; Sinfield JK; Donnelly D Functional coupling of Cys-226 and Cys-296 in the glucagon-like peptide-1 (GLP-1) receptor indicates a disulfide bond that is close to the activation pocket PEPTIDES 31 2289-2293, 2010
DOI:10.1016/j.peptides.2010.09.015

Mann R; Wigglesworth MJ; Donnelly D Ligand-receptor interactions at the parathyroid hormone receptors: Subtype binding selectivity is mediated via an interaction between residue 23 on the ligand and residue 41 on the receptor MOL PHARMACOL 74 605-613, 2008
DOI:10.1124/mol.108.048017

Weaver RE; Donnelly D; Wabitsch M; Grant PJ; Balmforth AJ Functional expression of glucose-dependent insulinotropic polypeptide receptors is coupled to differentiation in a human adipocyte model INT J OBESITY 32 1705-1711, 2008
DOI:10.1038/ijo.2008.148

Mann R; Nasr N; Hadden D; Sinfield J; Abidi F; Al-Sabah S; de Maturana RL; Treece-Birch J; Willshaw A; Donnelly D Peptide binding at the GLP-1 receptor BIOCHEM SOC T 35 713-716, 2007

Ellis J; Warburton P; Donnelly D; Balmforth AJ Conformational induction is the key process for activation of the AT(1) receptor BIOCHEM PHARMACOL 71 464-471, 2006
DOI:10.1016/j.bcp.2005.11.011

Cox A; Donnelly D; Kaur M; Cheetham SC; Cockcroft VB; Findlay JBC MTSEA prevents ligand binding to the human melanocortin-4 receptor by modification of cysteine 130 in transmembrane helix 3 FEBS LETT 579 285-291, 2005
DOI:10.1016/j.febslet.2004.11.087

de Maturana RL; Treece-Birch J; Abidi F; Findlay JBC; Donnelly D Met-204 and Tyr-205 are together important for binding GLP-1 receptor agonists but not their N-terminally truncated analogues PROTEIN PEPTIDE LETT 11 15-22, 2004

Al-Sabah S; Donnelly D The primary ligand-binding interaction at the GLP-1 receptor is via the putative helix of the peptide agonists PROTEIN PEPTIDE LETT 11 9-14, 2004

Al-Sabah S; Donnelly D A model for receptor-peptide binding at the glucagon-like peptide-1 (GLP-1) receptor through the analysis of truncated ligands and receptors BRIT J PHARMACOL 140 339-346, 2003
DOI:10.1038/sj.bjp.0705453

de Maturana RL; Willshaw A; Kuntzsch A; Rudolph R; Donnelly D The isolated N-terminal domain of the glucagon-like peptide-1 (GLP-1) receptor binds exendin peptides with much higher affinity than GLP-1 J BIOL CHEM 278 10195-10200, 2003
DOI:10.1074/jbc.M212147200

Al-Sabah S; Donnelly D The positive charge at Lys-288 of the glucagon-like peptide-1 (GLP-1) receptor is important for binding the N-terminus of peptide agonists FEBS LETT 553 342-346, 2003
DOI:10.1016/S0014-5793(03)01043-3

López de Maturana R; Donnelly D The glucagon-like peptide-1 receptor binding site for the N-terminus of GLP-1 requires polarity at Asp198 rather than negative charge. FEBS Lett 530 244-248, 2002
View abstract

de Maturana RL; Donnelly D The glucagon-like peptide-1 receptor binding site for the N-terminus of GLP-1 requires polarity at Asp198 rather than negative charge (FEBS 26658) (vol 530, pg 244, 2002) FEBS LETT 531 572-572, 2002

Donnelly D; Maudsley S; Moser RN; Hurrell CR; Gent JP; Findlay JBC Conserved polar residues in the transmembrane domain of the human tachykinin NK2 receptor: functional roles and structural implications. Biochemical Journal 339 56-61, 1999

Maudsley S; Gent JP; Findlay JBC; Donnelly D The relationship between the agonist-induced activation and desensitisation of the human tachykinin NK2 receptor expressed in Xenopus oocytes. British Journal of Pharmacology 124 675-684, 1998

Balmforth AJ; Lee AJ; Warburton P; Donnelly D; Ball SG The specificity of Peptide-Binding of the Angiotensin AT1 receptor is Dependent on an Interaction Between Transmembrane Helices III and VII Journal of Biological Chemistry 272 4245-4251, 1997

Balmforth AJ; Lee AJ; Shepherd FH; Warburton P; Donnelly D; Ball SG G-protein-coupled receptors for peptide hormones: angiotensin II receptors. Biochemical Society Transactions 25 1041-1046, 1997

Donnelly D The arrangement of the transmembrane helices in the secretin receptor family of G protein-coupled receptors FEBS Letters 409 431-436, 1997
View abstract