Faculty of Biological Sciences

Dr Michael Colman

UAF in CV Physiology/CV Exercise Physiology
School of Biomedical Sciences

Contact:  Garstang 7.56b, +44(0) 113 34 30340, email address for  

Faculty Research and Innovation

Modules taught

BMSC3140 - Advanced Scientific Skills
BMSC5301M - Advanced Research Topics

Dr Kathleen Wright  (Senior Scientific Officer in Cardiovascular Science)

Providing laboratory research support for multiple PIs, training new staff and laboratory/office management 

Postgraduates

Maxx Holmes (Primary supervisor) 60% FTE
Harley Stevenson-Cocks (Co-supervisor) 20% FTE

Colman MA, Perez Alday EA, Holden AV, Benson AP Trigger vs. substrate: Multi-dimensional modulation of QT-prolongation associated arrhythmic dynamics by a hERG channel activator Frontiers in Physiology 8 -, 2017
DOI:10.3389/fphys.2017.00757
View abstract

Colman MA, Pinali C, Trafford AW, Zhang H, Kitmitto A A computational model of spatio-temporal cardiac intracellular calcium handling with realistic structure and spatial flux distribution from sarcoplasmic reticulum and t-tubule reconstructions PLOS Computational Biology 13 -, 2017
DOI:10.1371/journal.pcbi.1005714
View abstract

Colman MA, Ni H, Liang B, Schmitt N, Zhang H In silico assessment of genetic variation in KCNA5 reveals multiple mechanisms of human atrial arrhythmogenesis PLoS Computational Biology 13 -, 2017
DOI:10.1371/journal.pcbi.1005587
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Alday EAP, Colman MA, Langley P, Zhang H Novel non-invasive algorithm to identify the origins of re-entry and ectopic foci in the atria from 64-lead ECGs: A computational study. PLoS Computational Biology 13 -, 2017
DOI:10.1371/journal.pcbi.1005270
View abstract

Alday EAP, Colman MA, Zhang H Reconstruction of atrial ectopic focal and Re-entrant excitations from body surface potentials. Insights from 3D virtual human atria and torso, 2017
DOI:10.22489/CinC.2016.205-397
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Jones GM, Zhang H, Colman MA The effect of bioenergetic impairment of cytosolic processes in spatio-temporal Ca²⁺ dynamics in a three-dimensional cardiomyocyte model, 2017
DOI:10.22489/CinC.2016.239-489
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Colman MA, Sarathy PP, MacQuiaide N, Workman AJ A new model of the human atrial myocyte with variable T-tubule organization for the study of atrial fibrillation, 2017
DOI:10.22489/CinC.2016.067-421
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Varela M, Colman MA, Hancox JC, Aslanidi OV Atrial Heterogeneity Generates Re-entrant Substrate during Atrial Fibrillation and Anti-arrhythmic Drug Action: Mechanistic Insights from Canine Atrial Models PLoS Computational Biology 12 -, 2016
DOI:10.1371/journal.pcbi.1005245
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Morgan R, Colman MA, Chubb H, Seemann G, Aslanidi OV Slow conduction in the border zones of patchy fibrosis stabilizes the drivers for atrial fibrillation: Insights from multi-scale human atrial modeling Frontiers in Physiology 7 -, 2016
DOI:10.3389/fphys.2016.00474
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Perez Alday EA, Ni H, Zhang C, Colman MA, Gan Z, Zhang H Comparison of electric- and magnetic-cardiograms produced by myocardial ischemia in models of the human ventricle and torso PLoS ONE 11 -, 2016
DOI:10.1371/journal.pone.0160999
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Atkinson L, Basharat A, Benson AP, Colman MA, Holden AV, Kagugube GW, Pervolaraki E Computational modelling of cardiac electrophysiological changes in malarial fever, 2016
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Whittaker DG, Colman MA, Ni H, Hancox JC, Zhang H In silico investigation of short QT syndrome-linked potassium channel mutations on electro-mechanical function of human atrial cells, 2015
DOI:10.1109/CIC.2015.7411045
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Perez Alday EA, Zhang C, Colman MA, Ni H, Gan Z, Zhang H Comparison of electric- and magnetic- cardiograms produced by myocardial ischemia in models of the human ventricle and torso, 2015
DOI:10.1109/CIC.2015.7410961
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Kottas P, Colman MA, Stephenson RS, Castro SJ, Hart G, Jarvis JC, Boyett M, Zhang H Effects of cardiac structural remodelling during heart failure on cardiac excitation - Insights from a heterogeneous 3D model of the rabbit atria, 2015
DOI:10.1109/CIC.2015.7411074
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Colman MA, Parra-Rojas C, Perez-Alday EA From microscopic calcium sparks to the ECG: Model reduction approaches for multi-scale cardiac simulation, 2015
DOI:10.1109/CIC.2015.7408652
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Jones GM, Colman MA, Zhang H Quantification of the effects of electrical remodeling due to hypertrophic cardiomyopathy on human ventricular electromechanical activity and energetics, 2015
DOI:10.1109/CIC.2015.7408685
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Alday EAP, Colman MA, Langley P, Butters TD, Higham J, Workman AJ, Hancox JC, Zhang H A New Algorithm to Diagnose Atrial Ectopic Origin from Multi Lead ECG Systems - Insights from 3D Virtual Human Atria and Torso PLoS Computational Biology 11 -, 2015
DOI:10.1371/journal.pcbi.1004026
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Colman MA, Varela M, Hancox JC, Zhang H, Aslanidi OV Evolution and pharmacological modulation of the arrhythmogenic wave dynamics in canine pulmonary vein model Europace 16 416-423, 2014
DOI:10.1093/europace/eut349
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Colman MA, Kharche S, Zhang H Loss of transverse-tubules promotes the development of ectopic activity in guinea-pig ventricle, 2014
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Ni H, Colman MA, Zhang H Modelling the functional impact of KCNA5 mutations on the electrical and mechanical activities of human atrial cells, 2014
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Colman MA, Castro SJ, Perez Alday EA, Hancox JC, Garratt C, Zhang H Recent progress in multi-scale models of the human atria Drug Discovery Today: Disease Models 14 23-32, 2014
DOI:10.1016/j.ddmod.2014.04.003
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Kharche SR, Stary T, Colman MA, Biktasheva IV, Workman AJ, Rankin AC, Holden AV, Zhang H Effects of human atrial ionic remodelling byβ-blocker therapy onmechanisms of atrial fibrillation: A computer simulation Europace 16 1524-1533, 2014
DOI:10.1093/europace/euu084
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Perez Alday EA, Colman MA, Langley P, Zhang H Spatial refinement of a new algorithm to identify focus of atrial ectopic activity from 64-lead ECGs, 2014
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Morgan R, Colman M, Kruger M, Seemann G, Rhode K, Aslanidi O Evaluating effects of fibrosis in atrial arrhythmogenesis using 3D computational modelling, 2014
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Kharche S, Castro S, Thomas B, Colman M, Jarvis J, Smaill B, Zhang H, Stephenson R, Zhao J Role of fiber orientation in atrial arrythmogenesis, 2014
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Perez Alday EA, Colman MA, Butters TD, Higham J, Giacopelli D, Langley P, Zhang H Diagnosis of atrial ectopic origin from the body surface ECG: Insights from 3D virtual human atria and torso, 2013
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Castro SJ, Colman MA, Kharche S, Wang R, Zhang H HCN and SCN5A channel mutations: Implications for impaired atrioventricular nodal conduction in a heterogeneous computer model of the whole mouse heart, 2013
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Colman MA, Aslanidi OV, Kharche S, Boyett MR, Garratt C, Hancox JC, Zhang H Pro-arrhythmogenic effects of atrial fibrillation-induced electrical remodelling: Insights from the three-dimensional virtual human atria Journal of Physiology 591 4249-4272, 2013
DOI:10.1113/jphysiol.2013.254987
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Aslanidi OV, Colman MA, Varela M, Zhao J, Smaill BH, Hancox JC, Boyett MR, Zhang H Heterogeneous and anisotropic integrative model of pulmonary veins: Computational study of arrhythmogenic substrate for atrial fibrillation Interface Focus 3 -, 2013
DOI:10.1098/rsfs.2012.0069
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Aslanidi OV, Colman MA, Zhao J, Smaill BH, Gilbert SH, Hancox JC, Boyett MR, Zhang H Arrhythmogenic substrate for atrial fibrillation: Insights from an integrative computational model of pulmonary veins, 2012
DOI:10.1109/EMBC.2012.6345906
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Colman MA, Giacopelli D, Langley P, Zhang H Elucidating the body surface P-wave using a detailed computer model of atrial activation, 2012
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Aslanidi OV, Al-Owais M, Benson AP, Colman M, Garratt CJ, Gilbert SH, Greenwood JP, Holden AV, Kharche S, Kinnell E, Pervolaraki E, Plein S, Stott J, Zhang H Virtual tissue engineering of the human atrium: Modelling pharmacological actions on atrial arrhythmogenesis European Journal of Pharmaceutical Sciences 46 209-221, 2012
DOI:10.1016/j.ejps.2011.08.014
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Colman MA, Aslanidi OV, Stott J, Holden AV, Zhang H Correlation between P-wave morphology and origin of atrial focal tachycardia-insights from realistic models of the human atria and torso IEEE Transactions on Biomedical Engineering 58 2952-2955, 2011
DOI:10.1109/TBME.2011.2161305
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Aslanidi OV, Colman MA, Stott J, Dobrzynski H, Boyett MR, Holden AV, Zhang H 3D virtual human atria: A computational platform for studying clinical atrial fibrillation Progress in Biophysics and Molecular Biology -, 2011