Faculty of Biological Sciences

Dr Joseph Cockburn

Lecturer in Macromolecular X-ray Crystallography
School of Molecular and Cellular Biology

Contact:  Astbury 8.111, +44(0) 113 34 30758, email address for  

Faculty Research and Innovation

Modules taught

BIOC1301 - Introductory Integrated Biochemistry: the Molecules and Processes of Life
BIOC1303 - Introductory Biochemistry: Problem Solving and Data Handling
BIOC2303 - Intermediate Biochemistry: Skills
BIOC3111/12/BIOL3112 B - ATU - Cytoskeletal Molecular Motors
BIOC3160 - Laboratory/Literature/Computing Research Project
BIOC3303 - Advanced Biochemistry: Skills
BIOL3305 - Advanced Skills in the Biosciences
BIOL3398 - Research Tools and Applications
BIOL3399 - Extended Research Project Preparation
BIOL5394M - Specialised Research Topics and Skills
FOBS1135/BIOL1112 - The Basis of Life/The molecules of life
MICR3080 - Microbiology Research Project
MICR3110 - Medical Microbiology Research Project

Postgraduates

Jack Bravo (Co-supervisor) 50% FTE
Sophie Hesketh (Co-supervisor) 50% FTE

Shakeel S, Dykeman EC, White SJ, Ora A, Cockburn JJB, Butcher SJ, Stockley PG, Twarock R Genomic RNA folding mediates assembly of human parechovirus Nature Communications 8 -, 2017
DOI:10.1038/s41467-016-0011-z
View abstract

Hesketh EL, Meshcheriakova Y, Dent KC, Saxena P, Thompson RF, Cockburn JJ, Lomonossoff GP, Ranson NA Mechanisms of assembly and genome packaging in an RNA virus revealed by high-resolution cryo-EM Nature Communications 6 -, 2015
DOI:10.1038/ncomms10113
View abstract

Cockburn JJB, Navarro Sanchez ME, Fretes N, Urvoas A, Staropoli I, Kikuti CM, Coffey LL, Arenzana Seisdedos F, Bedouelle H, Rey FA Mechanism of dengue virus broad cross-neutralization by a monoclonal antibody Structure 20 303-314, 2012
DOI:10.1016/j.str.2012.01.001
View abstract

Cockburn JJB, Navarro Sanchez ME, Goncalvez AP, Zaitseva E, Stura EA, Kikuti CM, Duquerroy S, Dussart P, Chernomordik LV, Lai CJ, Rey FA Structural insights into the neutralization mechanism of a higher primate antibody against dengue virus EMBO Journal 31 767-779, 2012
DOI:10.1038/emboj.2011.439
View abstract

Babault N, Cordier F, Lafage M, Cockburn J, Haouz A, Prehaud C, Rey FA, Delepierre M, Buc H, Lafon M, Wolff N Peptides targeting the PDZ domain of PTPN4 Are efficient inducers of glioblastoma cell death Structure 19 1518-1524, 2011
DOI:10.1016/j.str.2011.07.007
View abstract

Backovic M, DuBois RM, Cockburn JJ, Sharff AJ, Vaney MC, Granzow H, Klupp BG, Bricogne G, Mettenleiter TC, Rey FA Structure of a core fragment of glycoprotein H from pseudorabies virus in complex with antibody Proceedings of the National Academy of Sciences of the United States of America 107 22635-22640, 2010
DOI:10.1073/pnas.1011507107
View abstract

Abrescia NGA, Cockburn JJB, Grimes JM, Sutton GC, Diprose JM, Butcher SJ, Fuller SD, San Martín C, Burnett RM, Stuart DI, Bamford DH, Bamford JKH Insights into assembly from structural analysis of bacteriophage PRD1 Nature 432 68-74, 2004
DOI:10.1038/nature03056
View abstract

Cockburn JJB, Abrescia NGA, Grimes JM, Sutton GC, Diprose JM, Benevides JM, Thomas GJ, Bamford JKH, Bamford DH, Stuart DI Membrane structure and interactions with protein and DNA in bacteriophage PRD1 Nature 432 122-125, 2004
DOI:10.1038/nature03053
View abstract

Cockburn JJB, Bamford JKH, Grimes JM, Bamford DH, Stuart DI Crystallization of the membrane-containing bacteriophage PRD1 in quartz capillaries by vapour diffusion Acta Crystallographica - Section D Biological Crystallography 59 538-540, 2003
DOI:10.1107/S0907444902023491
View abstract

Bamford JKH, Cockburn JJB, Diprose J, Grimes JM, Sutton G, Stuart DI, Bamford DH Diffraction quality crystals of PRD1, a 66-MDa dsDNA virus with an internal membrane Journal of Structural Biology 139 103-112, 2002
DOI:10.1016/S1047-8477(02)00562-2
View abstract