Dr T. Scott Bowen

BSc (University of Leeds), MSc (Loughborough University), PhD (University of Leeds) 2008-2012, Postdoctoral Research Fellow (Heart Center Leipzig) 2013-2017
Lecturer in Exercise Physiology
School of Biomedical Sciences

Background: My PhD studies were performed at the University of Leeds under the supervision of Dr Harry Rossiter and helped better understand the cardiopulmonary and skeletal muscle limitations that occur during exercise in health and disease, particularly in heart failure patients. I was subsequently awarded a Postdoctoral Research Fellowship from the Alexander von Humboldt Foundation in Germany to support my postdoctoral studies at Leipzig Heart Center. Together with Professor Volker Adams, we investigated the basic molecular mechanisms that act to induce skeletal muscle weakness in numerous chronic diseases while further developing therapeutic treatments. Further involvement in an EU FP7 funded grant in collaboration with colleagues at NTNU in Norway provided key findings on the efficacy of exercise training in heart failure, while participation in a Fondation Leducq Transatlantic Network of Excellence revealed modulation of sarcomeric signalosomes as therapy to combat muscle wasting. I returned to the School of Biomedical Sciences at the University of Leeds in 2017 as an independent investigator.

Contact: Garstang 5.55q, +44(0) 113 34 33834, email address for  

You can read more about Dr Bowen's interests here:
https://www.researchgate.net/profile/T_Scott_Bowen
https://www.ncbi.nlm.nih.gov/pubmed/?term=Bowen+TS


Research Interests

Mechanisms of muscle weakness and wasting

Loss of muscle mass and strength occurs in many clinical conditions, and plays a critical role in pulmonary complications and disabilities observed in patients and leads to significant reductions in quality of life and survival. The aim of this laboratory is to identify key mechanisms contributing to muscle dysfunction in various diseases such as heart failure, and how this can be prevented through the development of novel therapies that include small-molecule inhibitors and exercise training. One particular area of interest is investigating why the main muscle of respiration, the diaphragm, becomes weak in acute and chronic disease.    

 

Key research areas include:

1) Molecular mediators of diaphragm weakness in heart failure

 

2) Underlying mechanisms contributing to skeletal muscle loss in various clinical disorders

 

3) Exercise training as a rescue intervention to prevent muscle impairments

 

4) Development of novel small-molecule therapeutics to protect against muscle wasting  

 

5) Mechanisms underpinning exacerbated exercise intolerance in diabetic heart failure patients

 

Modules managed

BMSC2216 - Exercise Physiology in Health and Disease
SPSC3326 - Exercise Prescription for Health and Disease

Modules taught

BMSC2228 - Experimental Skills in Physiology
SPSC2302 - Exercise Physiology in Sport, Health and Disease
SPSC2302/BMSC2216 - Exercise Physiology
SPSC3326 - Exercise Prescription for Health and Disease

Group Leader Dr T. Scott Bowen  (Lecturer in Exercise Physiology)

Mechanisms of muscle weakness and wasting  

Taylor BJ, Bowen TS Respiratory Muscle Weakness in Patients with Heart Failure: Time to Make It a Standard Clinical Marker and a Need for Novel Therapeutic Interventions? Journal of Cardiac Failure 24 217-218, 2018
DOI:10.1016/j.cardfail.2018.02.007
View abstract

Tan C, Rossiter HB, Porszasz J, Scott Bowen T, Witte KK, Stringer WW, Casaburi R, Hansen JE Reliability and physiological interpretation of pulmonary gas exchange by "circulatory equivalents" in chronic heart failure Journal of the American Heart Association 7, 2018
DOI:10.1161/JAHA.117.008072
View abstract

Bowen TS, Adams V, Werner S, Fischer T, Vinke P, Brogger MN, Mangner N, Linke A, Sehr P, Lewis J, Labeit D, Gasch A, Labeit S Small-molecule inhibition of MuRF1 attenuates skeletal muscle atrophy and dysfunction in cardiac cachexia Journal of Cachexia, Sarcopenia and Muscle 8 939-953, 2017
DOI:10.1002/jcsm.12233
View abstract

Bowen TS, Brauer D, Rolim NPL, Bækkerud FH, Kricke A, Ormbostad Berre A-M, Fischer T, Linke A, Da Silva GJ, Wisloff U, Adams V Exercise training reveals inflexibility of the diaphragm in an animal model of patients with obesity-driven heart failure with a preserved ejection fraction Journal of the American Heart Association 6, 2017
DOI:10.1161/JAHA.117.006416
View abstract

Benson AP, Scott Bowen T, Ferguson C, Murgatroyd SR, Rossiter HB Reply to Francescato et al.: Interpreting the averaging methods to estimate oxygen uptake kinetics parameters Journal of Applied Physiology 123 1019-, 2017
DOI:10.1152/japplphysiol.00532.2017

Benson AP, Bowen TS, Ferguson C, Murgatroyd SR, Rossiter HB Data collection, handling, and fitting strategies to optimize accuracy and precision of oxygen uptake kinetics estimation from breath-by-breath measurements Journal of applied physiology (Bethesda, Md. : 1985) 123 227-242, 2017
DOI:10.1152/japplphysiol.00988.2016
View abstract

Bowen T, Aakerøy L, Eisenkolb S, Kunth P, Bakkerud F, Wohlwend M, Ormbostad AM, Fischer T, Wisloff U, Schuler G, Steinshamn S, Adams V, Bronstad E Exercise Training Reverses Extrapulmonary Impairments in Smoke-exposed Mice Medicine&Science in Sports&Exercise 49 879-887, 2017
DOI:10.1249/MSS.0000000000001195
View abstract

Bowen TS, Eisenkolb S, Drobner J, Fischer T, Werner S, Linke A, Mangner N, Schuler G, Adams V High-intensity interval training prevents oxidantmediated diaphragm muscle weakness in hypertensive mice FASEB Journal 31 60-71, 2017
DOI:10.1096/fj.201600672R
View abstract

Mangner N, Bowen T, Werner S, Fischer T, Kullnick Y, Oberbach A, Linke A, Steil L, Schuler G, Adams V Exercise Training Prevents Diaphragm Contractile Dysfunction in Heart Failure Medicine&Science in Sports&Exercise 48 2118-2124, 2016
DOI:10.1249/MSS.0000000000001016
View abstract

Bowen TS, Eisenkolb S, Werner S, Schwarzer M, Schuler G, Adams V Inheriting a high aerobic fitness predisposes to skeletal muscle and endothelial dysfunction in chronic heart failure International Journal of Cardiology 203 353-356, 2016
DOI:10.1016/j.ijcard.2015.10.125

Bowen TS, Koga S, Amano T, Kondo N, Rossiter HB The spatial distribution of absolute skeletal muscle deoxygenation during ramp-incremental exercise is not influenced by hypoxia, 2016
DOI:10.1007/978-1-4939-3023-4_2
View abstract

Okushima D, Poole DC, Barstow TJ, Rossiter HB, Kondo N, Bowen TS, Amano T, Koga S Greater VO<inf>2peak</inf>is correlated with greater skeletal muscle deoxygenation amplitude and hemoglobin concentration within individual muscles during ramp-incremental cycle exercise Physiological Reports 4, 2016
DOI:10.14814/phy2.13065
View abstract

Bowen TS, Rolim NPL, Fischer T, Bækkerud FH, Medeiros A, Werner S, Brønstad E, Rognmo O, Mangner N, Linke A, Schuler G, Silva GJJ, Wisløff U, Adams V Heart failure with preserved ejection fraction induces molecular, mitochondrial, histological, and functional alterations in rat respiratory and limb skeletal muscle European Journal of Heart Failure 17 263-272, 2015
DOI:10.1002/ejhf.239
View abstract

Bowen TS, Mangner N, Werner S, Glaser S, Kullnick Y, Schrepper A, Doenst T, Oberbach A, Linke A, Steil L, Schuler G, Adams V Diaphragm muscle weakness in mice is early-onset post-myocardial infarction and associated with elevated protein oxidation Journal of Applied Physiology 118 11-19, 2015
DOI:10.1152/japplphysiol.00756.2014
View abstract

Benson AP, Bowen TS, Ferguson C, Murgatroyd SR, Rossiter HB Optimising Oxygen Uptake Kinetic Fitting Methods in Healthy Humans Ranging in Anatomical and Physiological Characteristics, 2014
DOI:10.1249/01.mss.0000493450.97825.e0

Cannon DT, Bimson WE, Hampson SA, Bowen TS, Murgatroyd SR, Marwood S, Kemp GJ, Rossiter HB Skeletal muscle ATP turnover by<sup>31</sup>P magnetic resonance spectroscopy during moderate and heavy bilateral knee extension Journal of Physiology 592 5287-5300, 2014
DOI:10.1113/jphysiol.2014.279174
View abstract

Bowen TS, Rossiter HB, Benson AP, Amano T, Kondo N, Kowalchuk JM, Koga S Slowed oxygen uptake kinetics in hypoxia correlate with the transient peak and reduced spatial distribution of absolute skeletal muscle deoxygenation Experimental Physiology 98 1585-1596, 2013
DOI:10.1113/expphysiol.2013.073270
View abstract

Benson AP, Bowen TS, Ferguson C, Murgatroyd SR, Rossiter HB An Algorithm To Optimise Fitting Of Phase 2 Pulmonary Oxygen Uptake Kinetics From Breath-by-Breath Measurements, 2013

Koga S, Wüst RCI, Walsh B, Kindig CA, Rossiter HB, Hogan MC Increasing temperature speeds intracellular Po<inf>2</inf>kinetics during contractions in single Xenopus skeletal muscle fibers American Journal of Physiology - Regulatory Integrative and Comparative Physiology 304, 2013
DOI:10.1152/ajpregu.00337.2012
View abstract

Hansen JE, Bowen TS, Witte KK, Rossiter HD Highest Exercise Circulatory Equivalents are Reproducible in Heart Failure Patients Despite Wide Differences in Ramp Rate Increments CIRCULATION 126, 2012

Scott Bowen T, Cannon DT, Begg G, Baliga V, Witte KK, Rossiter HB A novel cardiopulmonary exercise test protocol and criterion to determine maximal oxygen uptake in chronic heart failure Journal of Applied Physiology 113 451-458, 2012
DOI:10.1152/japplphysiol.01416.2011
View abstract

Bowen TS, Rossiter HB, Benson AP, Amano T, Kondo N, Kowalchuk JM, Koga S A Dynamic Overshoot In Skeletal Muscle Deoxygenation Is Not Evidence Of A VO2 Kinetic Limitation, 2012

Cannon DT, Bowen TS, Murgatroyd SR, Bimson WE, Kemp GJ, Rossiter HB ATP Turnover And The Coupling Of Mitochondrial Oxidative Phosphorylation During Dynamic Exercise In Humans, 2012

Murgatroyd SR, Ferguson C, Cannon DT, Bowen TS, Wylde LA, Porszasz J, Rossiter HB Quantifying Physiological Benefit from Improvements in Exercise Tolerance, 2012

Bowen TS, Cannon DT, Murgatroyd SR, Birch KM, Witte KK, Rossiter HB The intramuscular contribution to the slow oxygen uptake kinetics during exercise in chronic heart failure is related to the severity of the condition Journal of Applied Physiology 112 378-387, 2012
DOI:10.1152/japplphysiol.00779.2011
View abstract

Bowen TS, Murgatroyd SR, Cannon DT, Cuff TJ, Lainey AF, Marjerrison AD, Spencer MD, Benson AP, Paterson DH, Kowalchuk JM, Rossiter HB A raised metabolic rate slows pulmonary O<inf>2</inf>uptake kinetics on transition to moderate-intensity exercise in humans independently of work rate Experimental Physiology 96 1049-1061, 2011
DOI:10.1113/expphysiol.2011.058321
View abstract

Bowen TS, Cannon DT, Begg G, Baliga V, Rossiter HB, Witte KK A novel cardiopulmonary exercise test protocol and criterion to determine maximal oxygen uptake in chronic heart failure patients, 2011

Bowen TS, Cannon DT, Begg G, Baliga V, Witte KK, Rossiter HB A TEST TO CONFIRM MAXIMAL OXYGEN UPTAKE IN CHRONIC HEART FAILURE PATIENTS WITHOUT THE NEED FOR SECONDARY CRITERIA, 2011
DOI:10.1136/heartjnl-2011-300198.96

Bowen TS, Cannon DT, Begg G, Baliga V, Witte KK, Rossiter HB A TEST TO CONFIRM MAXIMAL OXYGEN UPTAKE IN CHRONIC HEART FAILURE PATIENTS WITHOUT THE NEED FOR SECONDARY CRITERIA, 2011
DOI:10.1136/heartjnl-2011-300198.96

Cannon DT, Bowen TS, Murgatroyd SR, Witte KK, Koga S, Rossiter HB Inferences from Skeletal Muscle Deoxygenation Kinetics during Constant and Incremental Exercise in Heart Failure, 2011
DOI:10.1249/01.MSS.0000403019.48163.0f

Bowen TS, Cannon DT, Murgatroyd SR, Witte KK, Rossiter HB Moderate-Intensity Exercise Increases Subsequent Muscle Oxygenation and Speeds VO2 Kinetics in Chronic Heart Failure, 2010

Bowen TS, Cannon DT, Murgatroyd SR, Witte KK, Rossiter HB Moderate-Intensity Exercise Increases Subsequent Muscle Oxygenation and Speeds VO2 Kinetics in Chronic Heart Failure, 2010
DOI:10.1249/01.MSS.0000384514.97046.b0

Cannon DT, Bowen TS, Witte KK, Rossiter HB Dissociating the Attainment of Maximal Oxygen Uptake from Symptom Limitation During Exercise in Heart Failure, 2010

Cannon DT, Bowen TS, Witte KK, Rossiter HB Dissociating the Attainment of Maximal Oxygen Uptake from Symptom Limitation During Exercise in Heart Failure, 2010
DOI:10.1249/01.MSS.0000385549.05606.19

Wust RCI, Benoist D, Stones R, Bowen TS, White E, Rossiter HB Adaptation of Skeletal Muscle O-2 Transport and Utilization in Rats with Right Heart Failure, 2010

Wuest RCI, Benoist D, Stones R, Bowen TS, White E, Rossiter HB Adaptation of Skeletal Muscle O-2 Transport and Utilization in Rats with Right Heart Failure, 2010

Cubbon RM, Murgatroyd SR, Ferguson C, Bowen TS, Rakobowchuk M, Baliga V, Cannon D, Rajwani A, Abbas A, Kahn M, Birch KM, Porter KE, Wheatcroft SB, Rossiter HB, Kearney MT Human exercise-induced circulating progenitor cell mobilization is nitric oxide-dependent and is blunted in South Asian men Arteriosclerosis, Thrombosis, and Vascular Biology 30 878-884, 2010
DOI:10.1161/ATVBAHA.109.201012
View abstract

Cubbon RM, Murgatroyd SR, Ferguson C, Bowen TS, Rakobowchuk M, Baliga V, Cannon D, Rajwani A, Abbas A, Kahn M, Birch KM, Porter KE, Wheatcroft SB, Rossiter HB, Kearney MT Human exercise induced circulating progenitor cell mobilisation is nitric oxide dependent and is blunted in South Asian men
DOI:10.1136/hrt.2010.195941.20

Bowen TS, Cannon DT, Murgatroyd SR, Witte KK, Rossiter HB Increasing skeletal muscle oxygenation by prior moderate-intensity exercise increases aerobic energy provision in chronic heart failure
DOI:10.1136/heartjnl-2011-300198.97