Faculty of Biological Sciences

Dr Helen Berry

BSc Microbiology, University of Leeds; PhD, University of Leeds
UAF in Cardiovascular Regenerative Therapies & Devices
School of Biomedical Sciences

Background: Postdoctoral Research Fellow, University of Leeds (2000-2006); Chief Scientist, Tissue Regenix Ltd (2007-2008); Research & Development Manager, Tissue Regenix Ltd (2008-2010); Research & Technical Manager, Tissue Regenix Ltd (2010-2015)

Contact:  Garstang 6.59, +44(0) 113 34 35617, email address for  

Research Interests

Elucidating the Mechanisms Underpinning the Immunomodulation and Regenerative Properties of Acellular Scaffolds

Research at the University of Leeds on the "Tissue Engineering a Living Heart Valve" and “Tissue Engineering Pericardial Patches for Cardiovascular Repair” projects led to the development of a decellularisation process for porcine heart valves and pericardium.  The regenerative potential of these acellular scaffolds was demonstrated in vivo, and insight was gained on the role of macrophages in the regenerative process.  Successful commercialisation of the decellularisation technology and continued collaborative research generated new acellular scaffolds, and insight into cell signalling mechanisms occurring at the acellular scaffold-tissue interface was gained.  Although, clinical use has been achieved for these acellular technologies; questions remain over the key drivers behind their regeneration into functional tissue.

My research focus is therefore on elucidating the mechanisms of immunomodulation and tissue regeneration in acellular scaffolds for cardiovascular repair and replacement, in conjunction with investigating translational issues such as bioprocessing and sterilisation methods.  Clinical success can be built upon by defining the mechanisms of action, and functional tolerances for natural matrix modification, to provide insight for new scaffold development; whilst targeted bioprocessing methods and integrated sterilisation strategies will increase the opportunity for the applied research to be translated into clinical practice.

 

Faculty Research and Innovation

Modules taught

BMSC1213 - Basic Laboratory and Scientific Skills 2
BMSC3238 - Biomedical Nanotechnology
BMSC3301 - Research Project in Biomedical Sciences
MECH5007M - Systematic Review
MECH5009M - Research Project Proposal
MEDI - Medical teaching

Centre membership: The Institute of Medical and Biological Engineering

Postgraduates

James Holland (Primary supervisor) 70% FTE
Fiona Walker (Primary supervisor) 50% FTE

Jones G, Herbert A, Berry H, Edwards JH, Fisher J, Ingham E Decellularization and characterization of porcine superflexor tendon: A potential anterior cruciate ligament replacement Tissue Engineering - Part A 23 124-134, 2017
DOI:10.1089/ten.tea.2016.0114
View abstract

Vafaee T, Thomas D, Desai A, Jennings LM, Berry H, Rooney P, Kearney J, Fisher J, Ingham E Decellularization of human donor aortic and pulmonary valved conduits using low concentration sodium dodecyl sulfate Journal of Tissue Engineering and Regenerative Medicine -, 2017
DOI:10.1002/term.2391
View abstract

Ingham E, Jones G, Herbert A, Berry H, Edwards J, Fisher J Decellularisation and characterisation of porcine superflexor tendon: a potential anterior cruciate ligament replacement, 2016
DOI:10.5518/39

Ingham E, Vafaee T, Thomas D, Desai A, Jennings L, Berry H, Rooney P, Kearney J, Fisher J Characteristics of low concentration SDS decellularised human donor aortic and pulmonary valved conduits., 2016
DOI:10.5518/42

Abdelgaied A, Stanley M, Galfe M, Berry H, Ingham E, Fisher J Comparison of the biomechanical tensile and compressive properties of decellularised and natural porcine meniscus Journal of Biomechanics 48 1389-1396, 2015
DOI:10.1016/j.jbiomech.2015.02.044
View abstract

Paniagua Gutierrez JR, Berry H, Korossis S, Mirsadraee S, Lopes SV, da Costa F, Kearney J, Watterson K, Fisher J, Ingham E Regenerative potential of low-concentration SDS-decellularized porcine aortic valved conduits in vivo. Tissue Eng Part A 21 332-342, 2015
DOI:10.1089/ten.tea.2014.0003
View abstract

Owen K, Wilshaw SP, Homer-Vanniasinkam S, Bojar RA, Berry H, Ingham E Initial wash-out of antimicrobial cocktails from acellular vascular grafts, 2012

Vafaee T, Thomas D, Rooney P, Kearney J, Berry H, Korossis S, Jennings LM, Fisher J, Ingham E Decellularisation of allogeneic aortic and pulmonary valves using low concentration SDS, 2012

Bullers S, Berry H, Ingham E, Southgate J The resolution of inflammation during the regeneration of biological scaffolds by human tissue, 2012

Owen K, Wilshaw SP, Homer-Vanniasinkam S, Bojar RA, Berry H, Ingham E Assessment of the antimicrobial activity of acellular vascular grafts European Journal of Vascular and Endovascular Surgery 43 573-581, 2012
DOI:10.1016/j.ejvs.2012.01.027
View abstract

Wilshaw SP, Rooney P, Berry H, Kearney JN, Homer-Vanniasinkam S, Fisher J, Ingham E Development and characterization of acellular allogeneic arterial matrices Tissue Engineering - Part A 18 471-483, 2012
DOI:10.1089/ten.tea.2011.0287
View abstract

Tatterton M, Wilshaw SP, Berry H, Kearney JN, Fisher J, Ingham E, Homer-Vanniasinkam S Tissue engineering small-diameter vascular grafts: decellularisation of porcine arteries, 2012

Bullers S, Berry H, Ingham E, Southgate J The role of macrophages in biomaterial-tissue regeneration, 2011

Owen K, Wilshaw SP, Homer-Vanniasinkam S, Bojar R, Berry H, Ingham E Assessment of the antimicrobial activity of acellular vascular grafts, 2011

Vafaee T, Thomas D, Rooney P, Kearney J, Berry H, Korossis S, Fisher J, Ingham E Acellular allogeneic cardiac valves, 2011

Jones GL, Llewellyn A, Berry H, Fisher J, Ingham E Decellularisation of super flexor tendon, 2011

Wilshaw SP, Berry H, Rooney P, Kearney JN, Homer-Vanniasinkam S, Fisher J, Ingham E Biocompatibility and immunoreactivity of acellular xenogeneic and allogeneic arteries, 2011

Bullers S, Berry H, Ingham E, Southgate J The host response to porcine-derived biomaterials - the role of the macrophage, 2010

Bullers S, Berry H, Ingham E, Southgate J The host response to porcine-derived biomaterials - the role of the macrophage, 2010

Knight RL, Wilcox HE, Korossis SA, Fisher J, Ingham E The use of acellular matrices for the tissue engineering of cardiac valves Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine 222 129-143, 2008
DOI:10.1243/09544119JEIM230
View abstract

Mirsadraee S, Wilcox HE, Watterson KG, Kearney JN, Hunt J, Fisher J, Ingham E Biocompatibility of Acellular Human Pericardium Journal of Surgical Research 143 407-414, 2007
DOI:10.1016/j.jss.2007.01.026
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Oswal D, Korossis S, Mirsadraee S, Wilcox HE, Watterson K, Fisher J, Ingham E Biomechanical characterization of decellularized and cross-linked bovine pericardium Journal of Heart Valve Disease 16 165-174, 2007
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Wilcox HE, Farrar MD, Cunliffe WJ, Holland KT, Ingham E Resolution of inflammatory acne vulgaris may involve regulation of CD4+ T-cell responses to Propionibacterium acnes British Journal of Dermatology 156 460-465, 2007
DOI:10.1111/j.1365-2133.2006.07631.x
View abstract

Oswal D, Korossis S, Mirsadraee S, Wilcox H, Watterson K, Fisher J, Ingham E Biomechanical characterisation of decellularised and cross linked bovine pericardium, 2006

Mirsadraee S, Wilcox HE, Korossis SA, Kearney JN, Watterson KG, Fisher J, Ingham E Development and characterization of an acellular human pericardial matrix for tissue engineering Tissue Engineering 12 763-773, 2006
DOI:10.1089/ten.2006.12.763
View abstract

Korossis SA, Wilcox HE, Watterson KG, Kearney JN, Ingham E, Fisher J In-vitro assessment of the functional performance of the decellularized intact porcine aortic root Journal of Heart Valve Disease 14 408-421, 2005
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Wilcox HE, Korossis SA, Booth C, Watterson KG, Kearney JN, Fisher J, Ingham E Biocompatibility and recellularization potential of an acellular porcine heart valve matrix Journal of Heart Valve Disease 14 228-236, 2005
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Knight RL, Booth C, Wilcox HE, Fisher J, Ingham E Tissue engineering of cardiac valves: Re-seeding of acellular porcine aortic valve matrices with human mesenchymal progenitor cells Journal of Heart Valve Disease 14 806-813, 2005
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Mirsadraee S, Wilcox HE, Korossis SA, Kearney JN, Fisher J, Ingham E Tissue engineered human pericardium: a potential decellularised matrix for bladder wall augmentation BJU INT 95 66-66, 2005

Mirsadraee S, Wilcox HE, Korossis SA, Kearney JN, Fisher J, Ingham E Tissue engineered human pericardium: a potential decellularised matrix for bladder wall augmentation BJU INTERNATIONAL 95 66-66, 2005

Wilcox HE, Korossis SA, Booth C, Watterson KG, Kearney JN, Fisher J, Ingham E Tissue engineering a living heart valve: Biological and biomechanical assessment of an acellular porcine valve matrix, 2004
View abstract

Mirsadraee S, Wilcox HE, Korossis SA, Kearney JN, Watterson KG, Fisher J, Ingham E Tissue engineering of pericardium: Development and characterisation of an acellular human pericardial matrix, 2004
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Korossis S, Wilcox H, Watterson K, Kearney J, Ingham E, Fisher J Hydrodynamic characterisation of the decellularised intact porcine aortic valve Proceedings of the IASTED International Conference on Biomechanics 288-296, 2003
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Wilcox HE, Korossis SA, Booth C, Watterson KG, Kearney JN, Fisher J, Ingham E Tissue engineering a living heart valve: Biological and biomechanical assessment of an acellular, porcine valve matrix, 2003

Booth C, Korossis SA, Wilcox HE, Watterson KG, Kearney JN, Fisher J, Ingham E Tissue engineering of cardiac valve protheses I: Development and histological characterization of an acellular porcine scaffold Journal of Heart Valve Disease 11 457-462, 2002
View abstract

Korossis SA, Booth C, Wilcox HE, Watterson KG, Kearney JN, Fisher J, Ingham E Tissue engineering of cardiac valve prostheses II: Biomechanical characterization of decellularized porcine aortic heart valves Journal of Heart Valve Disease 11 463-471, 2002
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Wilcox HE, Farrar MD, Cunliffe WJ, Holland KT, Ingham E Human peripheral blood mononuclear cell response to Propionibacterium acnes heat shock proteins in inflammatory acne vulgaris J INVEST DERMATOL 115 567-567, 2000

Wilcox HE, Farrar MD, Cunliffe WJ, Holland KT, Ingham E Human peripheral blood mononuclear cell response to Propionibacterium acnes heat shock proteins in inflammatory acne vulgaris JOURNAL OF INVESTIGATIVE DERMATOLOGY 115 567-567, 2000

Ingham E, Grundy I, Wilcox HE, Farrer M, Cunliffe WJ, Holland KT Antibodies to Propionibacterium acnes HSP 60 and 70 in patients with acne, resolved acne and controls J INVEST DERMATOL 115 568-568, 2000

Ingham E, Grundy I, Wilcox HE, Farrer M, Cunliffe WJ, Holland KT Antibodies to Propionibacterium acnes HSP 60 and 70 in patients with acne, resolved acne and controls JOURNAL OF INVESTIGATIVE DERMATOLOGY 115 568-568, 2000

Wilcox HE, Cunliffe WJ, Holland KT, Ingham E Human peripheral blood mononuclear cell response to Propionibacterium acnes and and heat shock proteins in inflammatory acne vulgaris J INVEST DERMATOL 113 478-478, 1999

Wilcox HE, Cunliffe WJ, Holland KT, Ingham E Human peripheral blood mononuclear cell response to Propionibacterium acnes and and heat shock proteins in inflammatory acne vulgaris JOURNAL OF INVESTIGATIVE DERMATOLOGY 113 478-478, 1999

Jappe U, Wilcox H, Ingham E, Holland KT Is there a mitogen or superantigen produced by propionibacterium acnes? J INVEST DERMATOL 113 481-481, 1999

Jappe U, Wilcox H, Ingham E, Holland KT Is there a mitogen or superantigen produced by propionibacterium acnes? JOURNAL OF INVESTIGATIVE DERMATOLOGY 113 481-481, 1999

Wilcox HE, Ashbee HR, Cunliffe WJ, Ingham E Characterisation of the human peripheral blood T-cell response to P-acnes. J INVEST DERMATOL 108 68-68, 1997

Wilcox HE, Ashbee HR, Cunliffe WJ, Ingham E Characterisation of the human peripheral blood T-cell response to P-acnes. JOURNAL OF INVESTIGATIVE DERMATOLOGY 108 68-68, 1997

Desai A, Vafaee T, Rooney P, Kearney JN, Berry HE, Ingham E, Fisher J, Jennings LM In vitro biomechanical and hydrodynamic characterisation of decellularised human pulmonary and aortic roots Journal of the Mechanical Behavior of Biomedical Materials -,
DOI:10.1016/j.jmbbm.2017.09.019
View abstract