Faculty of Biological Sciences

Prof Richard Bayliss

Professor in Molecular Medicine
School of Molecular and Cellular Biology

Contact:  Astbury 6.108a, +44(0) 113 34 39919, email address for  

Faculty Research and Innovation

Modules taught

BIOC1303 - Introductory Biochemistry: Problem Solving and Data Handling
BIOC3160 - Laboratory/Literature/Computing Research Project
BIOL3306 - Biological Sciences Research Project
BIOW5901X - Foundation module

Postgraduates

Ewa Rejnowicz (Primary supervisor) 100% FTE
Luke Trask (Primary supervisor) 50% FTE
Christopher Arter (Co-supervisor) 50% FTE
James Pitts (Co-supervisor) 33% FTE
Sarah Ward (Co-supervisor) 10% FTE

Sabir SR, Yeoh S, Jackson G, Bayliss R EML4-ALK Variants: Biological and Molecular Properties, and the Implications for Patients. Cancers (Basel) 9 -, 2017
DOI:10.3390/cancers9090118
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Bayliss R, Burgess SG, McIntyre PJ Switching Aurora-A kinase on and off at an allosteric site. FEBS J 284 2947-2954, 2017
DOI:10.1111/febs.14069
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Sampson J, O'Regan L, Dyer MJS, Bayliss R, Fry AM Hsp72 and Nek6 Cooperate to Cluster Amplified Centrosomes in Cancer Cells. Cancer Res -, 2017
DOI:10.1158/0008-5472.CAN-16-3233
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Chavali PL, Stojic L, Meredith LW, Joseph N, Nahorski MS, Sanford TJ, Sweeney TR, Krishna BA, Hosmillo M, Firth AE, Bayliss R, Marcelis CL, Lindsay S, Goodfellow I, Woods CG, Gergely F Neurodevelopmental protein Musashi-1 interacts with the Zika genome and promotes viral replication Science 357 83-88, 2017
DOI:10.1126/science.aam9243
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Bayliss R, Burgess SG, Leen E, Richards MW A moving target: Structure and disorder in pursuit of Myc inhibitors Biochemical Society Transactions 45 709-717, 2017
DOI:10.1042/BST20160328
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Woo CG, Seo S, Kim SW, Jang SJ, Park KS, Song JY, Lee B, Richards MW, Bayliss R, Lee DH, Choi J Differential protein stability and clinical responses of EML4 - ALKfusion variants to various ALK inhibitors in advanced ALK - rearranged non-small cell lung cancer Annals of Oncology 28 791-797, 2017
DOI:10.1093/annonc/mdw693
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Coxon CR, Wong C, Bayliss R, Boxall K, Carr KH, Fry AM, Hardcastle IR, Matheson CJ, Newell DR, Sivaprakasam M, Thomas H, Turner D, Yeoh S, Wang LZ, Griffin RJ, Golding BT, Cano C Structure-guided design of purine-based probes for selective Nek2 inhibition. Oncotarget 8 19089-19124, 2017
DOI:10.18632/oncotarget.13249
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Rennie YK, McIntyre PJ, Akindele T, Bayliss R, Jamieson AG A TPX2 Proteomimetic Has Enhanced Affinity for Aurora-A Due to Hydrocarbon Stapling of a Helix ACS Chemical Biology 11 3383-3390, 2016
DOI:10.1021/acschembio.6b00727
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Burgess SG, Grazia Concilio M, Bayliss R, Fielding AJ Detection of Ligand-induced Conformational Changes in the Activation Loop of Aurora-A Kinase by PELDOR Spectroscopy ChemistryOpen 5 531-534, 2016
DOI:10.1002/open.201600101
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Richards MW, Burgess SG, Poon E, Carstensen A, Eilers M, Chesler L, Bayliss R Structural basis of N-Myc binding by Aurora-A and its destabilization by kinase inhibitors. Proc Natl Acad Sci U S A 113 13726-13731, 2016
DOI:10.1073/pnas.1610626113
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Mitcheson DF, Bottrill AR, Carr K, Coxon CR, Cano C, Golding BT, Griffin RJ, Fry AM, Doerig C, Bayliss R, Tobin AB A new tool for the chemical genetic investigation of the Plasmodium falciparum Pfnek-2 NIMA-related kinase Malaria Journal 15 1-12, 2016
DOI:10.1186/s12936-016-1580-3
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Fry AM, O'Regan L, Montgomery J, Adib R, Bayliss R EML proteins in microtubule regulation and human disease. Biochemical Society Transactions 44 1281-1288, 2016
DOI:10.1042/BST20160125
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Hall G, Cullen E, Sawmynaden K, Arnold J, Fox S, Cowan R, Muskett FW, Matthews D, Merritt A, Kettleborough C, Cruikshank W, Taylor D, Bayliss R, Carr MD Structure of a Potential Therapeutic Antibody Bound to Interleukin-16 (IL-16): MECHANISTIC INSIGHTS AND NEW THERAPEUTIC OPPORTUNITIES. J Biol Chem 291 16840-16848, 2016
DOI:10.1074/jbc.M115.709303
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Burgess SG, Oleksy A, Cavazza T, Richards MW, Vernos I, Matthews D, Bayliss R Allosteric inhibition of Aurora-A kinase by a synthetic vNAR domain. Open Biol 6 -, 2016
DOI:10.1098/rsob.160089
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Khan S, Karmokar A, Howells L, Thomas AL, Bayliss R, Gescher A, Brown K Targeting cancer stem-like cells using dietary-derived agents - Where are we now? Mol Nutr Food Res 60 1295-1309, 2016
DOI:10.1002/mnfr.201500887
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Bachmann G, Richards MW, Winter A, Beuron F, Morris E, Bayliss R A closed conformation of the Caenorhabditis elegans separase-securin complex Open Biology 6 -, 2016
DOI:10.1098/rsob.160032
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Concilio MG, Fielding AJ, Bayliss R, Burgess SG Density functional theory studies of MTSL nitroxide side chain conformations attached to an activation loop Theoretical Chemistry Accounts 135 -, 2016
DOI:10.1007/s00214-016-1859-z
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Bayliss R, Choi J, Fennell DA, Fry AM, Richards MW Molecular mechanisms that underpin EML4-ALK driven cancers and their response to targeted drugs Cellular and Molecular Life Sciences 73 1209-1224, 2016
DOI:10.1007/s00018-015-2117-6
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Haq T, Richards MW, Burgess SG, Gallego P, Yeoh S, O'Regan L, Reverter D, Roig J, Fry AM, Bayliss R Mechanistic basis of Nek7 activation through Nek9 binding and induced dimerization Nature Communications 6 -, 2015
DOI:10.1038/ncomms9771
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Burgess SG, Bayliss R, Pfuhl M Solution NMR assignment of the cryptic sixth TOG domain of mini spindles Biomolecular NMR Assignments 9 411-413, 2015
DOI:10.1007/s12104-015-9620-4
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Bayliss R, Haq T, Yeoh S The Ys and wherefores of protein kinase autoinhibition Biochimica et Biophysica Acta - Proteins and Proteomics 1854 1586-1594, 2015
DOI:10.1016/j.bbapap.2015.04.025
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Bavetsias V, Pérez-Fuertes Y, McIntyre PJ, Atrash B, Kosmopoulou M, O'Fee L, Burke R, Sun C, Faisal A, Bush K, Avery S, Henley A, Raynaud FI, Linardopoulos S, Bayliss R, Blagg J 7-(Pyrazol-4-yl)-3H-imidazo[4,5-b]pyridine-based derivatives for kinase inhibition: Co-crystallisation studies with Aurora-A reveal distinct differences in the orientation of the pyrazole N1-substituent Bioorganic and Medicinal Chemistry Letters 25 4203-4209, 2015
DOI:10.1016/j.bmcl.2015.08.003
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Flayhan A, Bergé C, Baïlo N, Doublet P, Bayliss R, Terradot L The structure of Legionella pneumophila LegK4 type four secretion system (T4SS) effector reveals a novel dimeric eukaryotic-like kinase Scientific Reports 5 -, 2015
DOI:10.1038/srep14602
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Rogerson DT, Sachdeva A, Wang K, Haq T, Kazlauskaite A, Hancock SM, Huguenin-Dezot N, Muqit MMK, Fry AM, Bayliss R, Chin JW Efficient genetic encoding of phosphoserine and its nonhydrolyzable analog Nature Chemical Biology 11 496-503, 2015
DOI:10.1038/nchembio.1823
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Richards MW, O'Regan L, Roth D, Montgomery JM, Straube A, Fry AM, Bayliss R Microtubule association of EML proteins and the EML4-ALK variant 3 oncoprotein require an N-terminal trimerization domain Biochemical Journal 467 529-536, 2015
DOI:10.1042/BJ20150039
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Gutiérrez-Caballero C, Burgess SG, Bayliss R, Royle SJ TACC3-ch-TOG track the growing tips of microtubules independently of clathrin and Aurora-A phosphorylation Biology Open 4 170-179, 2015
DOI:10.1242/bio.201410843
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Joshi A, Newbatt Y, McAndrew PC, Stubbs M, Burke R, Richards MW, Bhatia C, Caldwell JJ, McHardy T, Collins I, Bayliss R Molecular mechanisms of human IRE1 activation through dimerization and ligand binding Oncotarget 6 13019-13035, 2015
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Burgess SG, Bayliss R The structure of C290A: C393A Aurora A provides structural insights into kinase regulation Acta Crystallographica Section F:Structural Biology Communications 71 315-319, 2015
DOI:10.1107/S2053230X15002290
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Burgess SG, Peset I, Joseph N, Cavazza T, Vernos I, Pfuhl M, Gergely F, Bayliss R Aurora-A-Dependent Control of TACC3 Influences the Rate of Mitotic Spindle Assembly PLoS Genetics 11 -, 2015
DOI:10.1371/journal.pgen.1005345
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O'Regan L, Sampson J, Richards MW, Knebel A, Roth D, Hood FE, Straube A, Royle SJ, Bayliss R, Fry AM Hsp72 is targeted to the mitotic spindle by Nek6 to promote K-fiber assembly and mitotic progression Journal of Cell Biology 209 349-358, 2015
DOI:10.1083/jcb.201409151
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Winter A, Schmid R, Bayliss R Structural Insights into Separase Architecture and Substrate Recognition through Computational Modelling of Caspase-Like and Death Domains PLoS Computational Biology 11 -, 2015
DOI:10.1371/journal.pcbi.1004548
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Rowan FC, Bayliss R, Blagg J Diverse functionalization of Aurora-A by chemical modification: Insights into kinase activation, 2014

Rowan F, Richards M, Widya M, Bayliss R, Blagg J Diverse functionalization of Aurora-A kinase at specified surface and buried sites by native chemical modification PLoS ONE 9 -, 2014
DOI:10.1371/journal.pone.0103935
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Fry AM, Leaper MJ, Bayliss R The primary cilium: Guardian of organ development and homeostasis Organogenesis 10 62-68, 2014
DOI:10.4161/org.28910
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Richards MW, Edward EW, Rennalls LP, Busacca S, O'Regan L, Fry AM, Fennell DA, Bayliss R Crystal structure of EML1 reveals the basis for Hsp90 dependence of oncogenic EML4-ALK by disruption of an atypicalβ-propeller domain Proceedings of the National Academy of Sciences of the United States of America 111 5195-5200, 2014
DOI:10.1073/pnas.1322892111
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Bojar D, Martinez J, Santiago J, Rybin V, Bayliss R, Hothorn M Crystal structures of the phosphorylated BRI1 kinase domain and implications for brassinosteroid signal initiation Plant Journal 78 31-43, 2014
DOI:10.1111/tpj.12445
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Bavetsias V, Faisal A, Crumpler S, Brown N, Kosmopoulou M, Joshi A, Atrash B, Pérez-Fuertes Y, Schmitt JA, Boxall KJ, Burke R, Sun C, Avery S, Bush K, Henley A, Raynaud FI, Workman P, Bayliss R, Linardopoulos S, Blagg J Aurora isoform selectivity: Design and synthesis of imidazo[4,5- B ]pyridine derivatives as highly selective inhibitors of aurora-A kinase in cells Journal of Medicinal Chemistry 56 9122-9135, 2013
DOI:10.1021/jm401115g
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Rowan FC, Richards M, Bibby RA, Thompson A, Bayliss R, Blagg J Insights into aurora-A kinase activation using unnatural amino acids incorporated by chemical modification ACS Chemical Biology 8 2184-2191, 2013
DOI:10.1021/cb400425t
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Hood FE, Williams SJ, Burgess SG, Richards MW, Roth D, Straube A, Pfuhl M, Bayliss R, Royle SJ Coordination of adjacent domains mediates TACC3-ch-TOG-clathrin assembly and mitotic spindle binding Journal of Cell Biology 202 463-478, 2013
DOI:10.1083/jcb.201211127
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Dodson CA, Haq T, Yeoh S, Fry AM, Bayliss R The structural mechanisms that underpin mitotic kinase activation Biochemical Society Transactions 41 1037-1041, 2013
DOI:10.1042/BST20130066
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Dodson CA, Yeoh S, Haq T, Bayliss R A kinetic test characterizes kinase intramolecular and intermolecular autophosphorylation mechanisms Science Signaling 6 -, 2013
DOI:10.1126/scisignal.2003910
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Fry AM, O'Regan L, Sabir SR, Bayliss R Cell cycle regulation by the NEK family of protein kinases Journal of Cell Science 125 4423-4433, 2012
DOI:10.1242/jcs.111195
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Carbain B, Bayliss R, Boxall K, Coxon C, Lebraud H, Matheson C, Turner D, Zhen-Wang L, Griffin RJ 2-arylamino-6-ethynylpurines as Potent Irreversible Inhibitors of the Mitotic Kinase Nek2, 2012

Bavetsias V, Crumpler S, Sun C, Avery S, Atrash B, Faisal A, Moore AS, Kosmopoulou M, Brown N, Sheldrake PW, Bush K, Henley A, Box G, Valenti M, De Haven Brandon A, Raynaud FI, Workman P, Eccles SA, Bayliss R, Linardopoulos S, Blagg J Optimization of imidazo[4,5- b ]pyridine-based kinase inhibitors: Identification of a dual FLT3/aurora kinase inhibitor as an orally bioavailable preclinical development candidate for the treatment of acute myeloid leukemia Journal of Medicinal Chemistry 55 8721-8734, 2012
DOI:10.1021/jm300952s
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Innocenti P, Cheung KMJ, Solanki S, Mas-Droux C, Rowan F, Yeoh S, Boxall K, Westlake M, Pickard L, Hardy T, Baxter JE, Aherne GW, Bayliss R, Fry AM, Hoelder S Design of potent and selective hybrid inhibitors of the mitotic kinase nek2: Structure-activity relationship, structural biology, and cellular activity Journal of Medicinal Chemistry 55 3228-3241, 2012
DOI:10.1021/jm201683b
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Fearon D, Jones K, Bayliss R, Bavetsias V New structural templates for kinase inhibition, 2012

Zalli D, Bayliss R, Fry AM The Nek8 protein kinase, mutated in the human cystic kidney disease nephronophthisis, is both activated and degraded during ciliogenesis HUMAN MOLECULAR GENETICS 21 1155-1171, 2012
DOI:10.1093/hmg/ddr544

Dodson CA, Bayliss R Activation of Aurora-A kinase by protein partner binding and phosphorylation are independent and synergistic Journal of Biological Chemistry 287 1150-1157, 2012
DOI:10.1074/jbc.M111.312090
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Bayliss R, Fry A, Haq T, Yeoh S On the molecular mechanisms of mitotic kinase activation Open Biology 2 -, 2012
DOI:10.1098/rsob.120136
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Solanki S, Innocenti P, Mas-Droux C, Boxall K, Barillari C, Van Montfort RLM, Aherne GW, Bayliss R, Hoelder S Benzimidazole inhibitors induce a DFG-out conformation of never in mitosis gene a-related kinase 2 (Nek2) without binding to the back pocket and reveal a nonlinear structure-activity relationship Journal of Medicinal Chemistry 54 1626-1639, 2011
DOI:10.1021/jm1011726
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Oberoi J, Richards MW, Crumpler S, Brown N, Blagg J, Bayliss R Structural basis of poly(ADP-ribose) recognition by the multizinc binding domain of Checkpoint with Forkhead-associated and RING domains (CHFR) Journal of Biological Chemistry 285 39348-39358, 2010
DOI:10.1074/jbc.M110.159855
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Whelligan DK, Solanki S, Taylor D, Thomson DW, Cheung KMJ, Boxall K, Mas-Droux C, Barillari C, Burns S, Grummitt CG, Collins I, Van Montfort RLM, Aherne GW, Bayliss R, Hoelder S Aminopyrazine inhibitors binding to an unusual inactive conformation of the mitotic kinase Nek2: SAR and structural characterization Journal of Medicinal Chemistry 53 7682-7698, 2010
DOI:10.1021/jm1008727
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Bouloc N, Large JM, Kosmopoulou M, Sun C, Faisal A, Matteucci M, Reynisson J, Brown N, Atrash B, Blagg J, McDonald E, Linardopoulos S, Bayliss R, Bavetsias V Structure-based design of imidazo[1,2-a]pyrazine derivatives as selective inhibitors of Aurora-A kinase in cells Bioorganic and Medicinal Chemistry Letters 20 5988-5993, 2010
DOI:10.1016/j.bmcl.2010.08.091
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Bavetsias V, Large JM, Sun C, Bouloc N, Kosmopoulou M, Matteucci M, Wilsher NE, Martins V, Reynisson J, Atrash B, Faisal A, Urban F, Valenti M, De Haven Brandon A, Box G, Raynaud FI, Workman P, Eccles SA, Bayliss R, Blagg J, Linardopoulos S, McDonald E Imidazo[4,5-b]pyridine derivatives as inhibitors of aurora kinases: Lead optimization studies toward the identification of an orally bioavailable preclinical development candidate Journal of Medicinal Chemistry 53 5213-5228, 2010
DOI:10.1021/jm100262j
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Dodson CA, Kosmopoulou M, Richards MW, Atrash B, Bavetsias V, Blagg J, Bayliss R Crystal structure of an Aurora-A mutant that mimics Aurora-B bound to MLN8054: Insights into selectivity and drug design (Biochemical Journal (2009) 427, (19-28)) Biochemical Journal 427 551-, 2010

Dodson CA, Kosmopoulou M, Richards MW, Atrash B, Bavetsias V, Blagg J, Bayliss R Crystal structure of an Aurora-A mutant that mimics Aurora-B bound to MLN8054: Insights into selectivity and drug design Biochemical Journal 427 19-28, 2010
DOI:10.1042/BJ20091530
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Richards MW, Leung JWC, Roe SM, Li K, Chen J, Bayliss R A Pocket on the Surface of the N-Terminal BRCT Domain of Mcph1 Is Required to Prevent Abnormal Chromosome Condensation Journal of Molecular Biology 395 908-915, 2010
DOI:10.1016/j.jmb.2009.11.029
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Bibby RA, Tang C, Faisal A, Drosopoulos K, Lubbe S, Houlston R, Bayliss R, Linardopoulos S A cancer-associated Aurora a mutant is mislocalized and misregulated due to loss of interaction with TPX2 Journal of Biological Chemistry 284 33177-33184, 2009
DOI:10.1074/jbc.M109.032722
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Richards MW, O'Regan L, Mas-Droux C, Blot JMY, Cheung J, Hoelder S, Fry AM, Bayliss R An Autoinhibitory Tyrosine Motif in the Cell-Cycle-Regulated Nek7 Kinase Is Released through Binding of Nek9 Molecular Cell 36 560-570, 2009
DOI:10.1016/j.molcel.2009.09.038
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Westwood I, Cheary DM, Baxter JE, Richards MW, van Montfort RLM, Fry AM, Bayliss R Insights into the Conformational Variability and Regulation of Human Nek2 Kinase Journal of Molecular Biology 386 476-485, 2009
DOI:10.1016/j.jmb.2008.12.033
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Jakubowski SJ, Kerr JE, Garza I, Krishnamoorthy V, Bayliss R, Waksman G, Christie PJ Agrobacterium VirB10 domain requirements for type IV secretion and T pilus biogenesis Molecular Microbiology 71 779-794, 2009
DOI:10.1111/j.1365-2958.2008.06565.x
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Hare S, Fischer W, Williams R, Terradot L, Bayliss R, Haas R, Waksman G Identification, structure and mode of action of a new regulator of the Helicobacter pylori HP0525 ATPase EMBO Journal 26 4926-4934, 2007
DOI:10.1038/sj.emboj.7601904
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Richter S, Lindenstrauss U, Lücke C, Bayliss R, Brüser T Functional tat transport of unstructured, small, hydrophilic proteins Journal of Biological Chemistry 282 33257-33264, 2007
DOI:10.1074/jbc.M703303200
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Bayliss R, Harris R, Coutte L, Monier A, Fronzes R, Christie PJ, Driscoll PC, Waksman G NMR structure of a complex between the VirB9/VirB7 interaction domains of the pKM101 type IV secretion system Proceedings of the National Academy of Sciences of the United States of America 104 1673-1678, 2007
DOI:10.1073/pnas.0609535104
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Harris R, Bayliss R, Waksman G, Driscoll PC Resonance assignments of the complex between TraN and the C-terminal domain of TraO from the conjugative plasmid pKM101 [29] Journal of Biomolecular NMR 36 31-, 2006
DOI:10.1007/s10858-006-0015-9

Hare S, Bayliss R, Baron C, Waksman G A Large Domain Swap in the VirB11 ATPase of Brucella suis Leaves the Hexameric Assembly Intact Journal of Molecular Biology 360 56-66, 2006
DOI:10.1016/j.jmb.2006.04.060
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Paschos A, Patey G, Sivanesan D, Gao C, Bayliss R, Waksman G, O'Callaghan D, Baron C Dimerization and interactions of Brucella suis VirB8 with VirB4 and VirB10 are required for its biological activity Proceedings of the National Academy of Sciences of the United States of America 103 7252-7257, 2006
DOI:10.1073/pnas.0600862103
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Terradot L, Bayliss R, Oomen C, Leonard GA, Baron C, Waksman G Structures of two core subunits of the bacterial type IV secretion system, VirB8 from Brucella suis and ComB10 from Helicobacter pylori Proceedings of the National Academy of Sciences of the United States of America 102 4596-4601, 2005
DOI:10.1073/pnas.0408927102
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Bayliss R, Sardon T, Ebert J, Lindner D, Vernos I, Conti E Determinants for Aurora-A activation and Aurora-B discrimination by TPX2 Cell Cycle 3 404-407, 2004
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Bayliss R, Sardon T, Vernos I, Conti E Structural basis of Aurora-A activation by TPX2 at the mitotic spindle Molecular Cell 12 851-862, 2003
DOI:10.1016/S1097-2765(03)00392-7
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Bayliss R, Littlewood T, Strawn LA, Wente SR, Stewart M GLFG and FxFG nucleoporins bind to overlapping sites on importin-β Journal of Biological Chemistry 277 50597-50606, 2002
DOI:10.1074/jbc.M209037200
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Bayliss R, Leung SW, Baker RP, Quimby BB, Corbett AH, Stewart M Structural basis for the interaction between NTF2 and nucleoporin FxFG repeats EMBO Journal 21 2843-2853, 2002
DOI:10.1093/emboj/cdf305
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Quimby BB, Leung SW, Bayliss R, Harreman MT, Thirumala G, Stewart M, Corbett AH Functional Analysis of the Hydrophobic Patch on Nuclear Transport Factor 2 Involved in Interactions with the Nuclear Pore in Vivo Journal of Biological Chemistry 276 38820-38829, 2001
DOI:10.1074/jbc.M105054200
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Stewart M, Baker RP, Bayliss R, Clayton L, Grant RP, Littlewood T, Matsuura Y Molecular mechanism of translocation through nuclear pore complexes during nuclear protein import FEBS Letters 498 145-149, 2001
DOI:10.1016/S0014-5793(01)02489-9
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Bayliss R, Corbett AH, Stewart M The molecular mechanism of transport of macromolecules through nuclear pore complexes Traffic 1 448-456, 2000
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Bayliss R, Kent HM, Corbett AH, Stewart M Crystallization and initial X-ray diffraction characterization of complexes of FxFG nucleoporin repeats with nuclear transport factors Journal of Structural Biology 131 240-247, 2000
DOI:10.1006/jsbi.2000.4297
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Bayliss R, Littlewood T, Stewart M Structural basis for the interaction between FxFG nucleoporin repeats and importin-β in nuclear trafficking Cell 102 99-108, 2000
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Bayliss R, Ribbeck K, Akin D, Kent HM, Feldherr CM, Görlich D, Stewart M Interaction between NTFP and xFxFG-containing nucleoporins is required to mediate nuclear import of RanGDP Journal of Molecular Biology 293 579-593, 1999
DOI:10.1006/jmbi.1999.3166
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