Dr Moza Al-Owais

Research Fellow
School of Biomedical Sciences

Contact: Garstang 7.63, +44(0) 113-34-34810, email address for  

Cheng L, Al-Owais M, Covarrubias ML, Koch WJ, Manning DR, Peers C, Riobo-Del Galdo NA Coupling of Smoothened to inhibitory G proteins reduces voltage-gated K+ currents in cardiomyocytes and prolongs cardiac action potential duration. The Journal of biological chemistry 293 11022-11032, 2018
DOI:10.1074/jbc.ra118.001989
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Kirton HM, Al-Owais M, Peers C, Steele DS The EPAC2 Inhibitor ESI-05 Prolongs the Action Potential and Increases Susceptibility to EAD Arrhythmias, 2018

Al-Owais MM, Hettiarachchi NT, Boyle JP, Scragg JL, Elies J, Dallas ML, Lippiat JD, Steele DS, Peers C Multiple mechanisms mediating carbon monoxide inhibition of the voltage-gated K + channel Kv1.5 Cell Death and Disease 8, 2017
DOI:10.1038/cddis.2017.568
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Al-Owais MM, Hettiarachchi NT, Kirton HM, Hardy ME, Boyle JP, Scragg JL, Steele DS, Peers C A key role for peroxynitrite-mediated inhibition of cardiac ERG (Kv11.1) K+ channels in carbon monoxide-induced proarrhythmic early afterdepolarizations FASEB journal : official publication of the Federation of American Societies for Experimental Biology 31 4845-4854, 2017
DOI:10.1096/fj.201700259R
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Yang Z, Kirton HM, Al-Owais M, Thireau J, Richard S, Peers C, Steele DS Epac2-Rap1 signaling regulates reactive oxygen species production and susceptibility to cardiac arrhythmias Antioxidants and Redox Signaling 27 117-132, 2017
DOI:10.1089/ars.2015.6485
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Hettiarachchi NT, Boyle JP, Dallas ML, Al-Owais MM, Scragg JL, Peers C Heme oxygenase-1 derived carbon monoxide suppresses Aβ<inf>1-42</inf>toxicity in astrocytes Cell Death and Disease 8, 2017
DOI:10.1038/cddis.2017.276
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Yang Z, Kirton HM, Al-Owais M, Peers C, Steele DS Epac2-Rap1 Signaling Influences Reactive Oxygen Species Production and Susceptibility to Cardiac Arrhythmias, 2017
DOI:10.1016/j.bpj.2016.11.576

Peers C, Boyle JP, Scragg JL, Dallas ML, Al-Owais MM, Hettiarachichi NT, Elies J, Johnson E, Gamper N, Steele DS Diverse mechanisms underlying the regulation of ion channels by carbon monoxide. Br J Pharmacol 172 1546-1556, 2015
DOI:10.1111/bph.12760
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Duckles H, Boycott HE, Al-Owais MM, Elies J, Johnson E, Dallas ML, Porter KE, Giuntini F, Boyle JP, Scragg JL, Peers C Heme oxygenase-1 regulates cell proliferation via carbon monoxide-mediated inhibition of T-type Ca2+ channels. Pflugers Arch 467 415-427, 2015
DOI:10.1007/s00424-014-1503-5
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Duckles H, Al-Owais MM, Elies J, Johnson E, Boycott HE, Dallas ML, Porter KE, Boyle JP, Scragg JL, Peers C T-type Ca&lt;sup&gt;2+&lt;/sup&gt; channel regulation by CO: A mechanism for control of cell proliferation, 2015
DOI:10.1007/978-3-319-18440-1_33
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Al-Owais MM, Dallas ML, Boyle JP, Scragg JL, Peers C Heme oxygenase-1 influences apoptosis via CO-mediated inhibition of k&lt;sup&gt;+&lt;/sup&gt; channels, 2015
DOI:10.1007/978-3-319-18440-1_39
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Hettiarachchi NT, Dallas ML, Al-Owais MM, Griffiths HH, Hooper NM, Scragg JL, Boyle JP, Peers C Heme oxygenase-1 protects against Alzheimer's amyloid-β&lt;inf&gt;1-42&lt;/inf&gt;-induced toxicity via carbon monoxide production Cell Death and Disease 5, 2014
DOI:10.1038/cddis.2014.529
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Aslanidi OV, Al-Owais M, Benson AP, Colman M, Garratt CJ, Gilbert SH, Greenwood JP, Holden AV, Kharche S, Kinnell E, Pervolaraki E, Plein S, Stott J, Zhang H Virtual tissue engineering of the human atrium: modelling pharmacological actions on atrial arrhythmogenesis. Eur J Pharm Sci 46 209-221, 2012
DOI:10.1016/j.ejps.2011.08.014
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Al-Owais MMA, Scragg JL, Dallas ML, Boycott HE, Warburton P, Chakrabarty A, Boyle JP, Peers C Carbon monoxide mediates the anti-apoptotic effects of heme oxygenase-1 in medulloblastoma DAOY cells via K+ channel inhibition. J Biol Chem 287 24754-24764, 2012
DOI:10.1074/jbc.M112.357012
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Boyle JP, Hettiarachchi NT, Wilkinson JA, Pearson HA, Scragg JL, Lendon C, Al-Owais MM, Kim CB, Myers DM, Warburton P, Peers C Cellular consequences of the expression of Alzheimer's disease-causing presenilin 1 mutations in human neuroblastoma (SH-SY5Y) cells. Brain Res 1443 75-88, 2012
DOI:10.1016/j.brainres.2011.12.061
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Benson AP, Al-Owais M, Holden AV Quantitative prediction of the arrhythmogenic effects of de novo hERG mutations in computational models of human ventricular tissues. Eur Biophys J 40 627-639, 2011
DOI:10.1007/s00249-010-0663-2
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Al-Owais M, Bracey K, Wray D Role of intracellular domains in the function of the herg potassium channel. Eur Biophys J 38 569-576, 2009
DOI:10.1007/s00249-009-0408-2
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Benson AP, Al-Owais M, Tong WC, Holden AV HERG Effects on Ventricular Action Potential Duration and Tissue Vulnerability: A Computational Study, 2009

Jeremy Craven C, Al-Owais M, Parker MJ A systematic analysis of backbone amide assignments achieved via combinatorial selective labelling of amino acids. J Biomol NMR 38 151-159, 2007
DOI:10.1007/s10858-007-9157-7
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Al-Owais M, Hesse L, Talbot SJ, Adams DJ Human non-pregnancy ribonuclease with anti-Kaposi's sarcoma activity Cancer Letters 176 183-189, 2002
DOI:10.1016/S0304-3835(01)00760-1