Dr Joseph Ainscough

Research Fellow
School of Molecular and Cellular Biology

Contact: Garstang 8.53, +44(0) 113 34 32990, email address for  

Ainscough JS, MacLeod T, McGonagle D, Brakefield R, Baron JM, Alase A, Wittmann M, Stacey M Cathepsin S is the major activator of the psoriasisassociated proinflammatory cytokine IL-36γ Proceedings of the National Academy of Sciences of the United States of America 114 E2748-E2757, 2017
DOI:10.1073/pnas.1620954114
View abstract

Wittmann M, Macleod T, Ainscough JS, Alase A, McGonagle D, Doble R, Latzko A, Stacey M Activation of IL-36 molecules and their role in psoriatic disease., 2016

Ainscough JS, Macleod T, Alase A, Latzko A, Whittmann M, Stacey M Cathepsin S is up-regulated in psoriatic inflammation and activates the pro-inflammatory cytokine IL-36 gamma, 2016
DOI:10.1016/j.jid.2016.06.405

Ainscough JS, Gerberick GF, Kimber I, Dearman RJ Interleukin-1β processing is dependent on a calcium-mediated interaction with calmodulin Journal of Biological Chemistry 290 31151-31161, 2015
DOI:10.1074/jbc.M115.680694
View abstract

Englezou PC, Rothwell SW, Ainscough JS, Brough D, Landsiedel R, Verkhratsky A, Kimber I, Dearman RJ P2X<inf>7</inf>R activation drives distinct IL-1 responses in dendritic cells compared to macrophages Cytokine 74 293-304, 2015
DOI:10.1016/j.cyto.2015.05.013
View abstract

Berekméri A, Latzko A, Alase A, Macleod T, Ainscough JS, Laws P, Goodfield M, Wright A, Helliwell P, Edward S, Dermpath D, Brown G, Reid D, Wenzel J, Stacey M, Wittmann M Detection of IL-36γ protein by non-invasive tape stripping provides a reliable approach to discriminate psoriasis from atopic eczema Journal of Allergy and Clinical Immunology