Publications
Yang, Y., Baboolal, T. G., Siththanandan, V. Chen, M.,,Walker, M. L.,Knight, P. J.,Peckham, M. & Sellers, J. R. (2009) A FERM domain autoregulates Drosophila myosin 7a activity. Proc Natl Acad Sci U S A.106,4189-94 Peckham, M. (2008) Engineering a multinucleated myotube, the role of the actin cytoskeleton. J. Micros. 231, 486-93. Dunn, S., Morrison, E. E., Liverpool, T. B., Molina-Paris, C., Cross, R. A., Alonso, M. C. and Peckham, M. (2008). Differential trafficking of Kif5c on tyrosinated and detyrosinated microtubules in live cells. J Cell Sci 121, 1085-95. Peltzer, J., Colman, L., Cebrian, J., Musa, H., Peckham, M. and Keller, A. (2008). Novel murine clonal cell lines either express slow or mixed (fast and slow) muscle markers following differentiation in vitro. Dev Dyn 237, 1412-1423. Domazetovska, A., Ilkovski, B., Kumar, V., Valova, V. A., Vandebrouck, A., Hutchinson, D. O., Robinson, P. J., Cooper, S. T., Sparrow, J. C., Peckham, M. et al. (2007). Intranuclear rod myopathy: molecular pathogenesis and mechanisms of weakness. Ann Neurol 62, 597-608. Musa, M., Meek, S., Gautel, M., Peddie, D., Smith, A., and Peckham, M. (2006) Targeted homozygous deletion of M-band titin in cardiomyocytes prevents sarcomere formation. J. Cell Sci. 119 :4322-31. Abstract Mashanov, GI, Nenasheva, TA, Peckham, M. and Molloy, JE. (2006) Cell biochemistry studied by single molecule imaging. Biochem. Soc. Trans. 34 :983-8 Abstract Peckham, M. (2006) Journal Club in Research Highlights , Nature 439, p895 Swailes, NT, Colegrave, M., Knight, P.J. & Peckham, M. (2006) Non-muscle myosins 2A and 2B drive changes in cell morphology that occur as myoblasts align and fuse. J. Cell Sci. 119, 3561-70 Abstract. Murphy JE, Tacon, D., Tedbury, PR., Hadden, JM., Knowling, S., Sawamura, T., Peckham, M., Phillips, SE., Walker, JH and Ponnambalam, S. (2006) LOX-1 scavenger receptor mediates calcium-dependent recognition of phosphatidylserine and apoptotic cells. Biochemical J. 393, 107-15 Paper Knight, P. J., Thirumurugan, K., Yu, Y., Wang, F., Kalverda, A. P., Stafford, W. F., 3rd, Sellers, J. R. and Peckham, M. (2005). The predicted coiled-coil domain of myosin 10 forms a novel elongated domain that lengthens the head. J. Biol. Chem. 280, 34702-8 Paper G.I. Mashanov, D. Tacon, M. Peckham, J.E. Molloy (2004) The spatial and temporal dynamics of pleckstrin homology domain binding at the plasma membrane measured by imaging single molecules in live mouse myoblasts. J. Biol. Chem. PDF Miller, G., Musa, H. & Peckham, M. (2003) A targeted deletion of the C-terminal end of titin, including the titin kinase domain, impairs myofibrillogenesis. J. Cell. Sci. 116 , 4811-4819. Abstract Musa, H., Orton, C., Morrison, E & Peckham, M. (2003) Microtubule assembly in cultured myoblasts and myotubes following nocodazole induced microtubule depolymerisation. J. Mus. Res. & Cell Motil. 24, 303-310. Abstract Miller G, Maycock J, White E, Peckham M , Calaghan S. (2003) Heterologous expression of wild-type and mutant beta-cardiac myosin changes the contractile kinetics of cultured mouse myotubes. J. Physiol. Apr 1;548(Pt 1):167-74. Abstract Mashanov GI, Tacon D, Knight AE, Peckham M , Molloy JE. (2003) Visualizing single molecules inside living cells using total internal reflection fluorescence microscopy. Methods. Feb;29(2):142-52. Abstract Natali AJ, Wilson LA, Peckham M , Turner DL, Harrison SM, White E.(2002) Different regional effects of voluntary exercise on the mechanical and electrical properties of rat ventricular myocytes. J. Physiol. Jun 15;541(Pt 3):863-75. Abstract Clark P, Dunn GA, Knibbs A, Peckham M.(2002) Alignment of myoblasts on ultrafine gratings inhibits fusion in vitro.Int J Biochem Cell Biol. Jul;34(7):816-25. Abstract Peckham, M .,
Miller, G., Wells, C., Zicha, D. and Dunn, G. A. (2001) Specific changes
to the mechanism of cell locomotion induced by overexpression of (beta)-actin. J. Cell Sci . 114 , 114(Pt 7):1367-77. Abstract : G. Miller, M. Colegrave & M. Peckham (2000) N232S, G741R and D778G beta -cardiac myosin mutants, implicated in familial hypertrophic cardiomyopathy, do not disrupt myofibrillar organisation in cultured myotubes. Febs Letts., 486 325-327. Maggs, A.M., Taylor-Harris, P., Peckham, M & Hughes, S.M. (2000) Evidence for differential post-translational modifications of slow myosin heavy chain during murine skeletal muscle development. J. Mus. Res. Cell Motil., 21 , 101-3. Abstract. Juliette M. Harris, Jennifer E. Morgan, J. David Rosenblatt, Michelle Peckham , Yvonne H. Edwards, Terence A. Partridge, Andrew C. G. Porter. (1999) Forced MyHCIIB Expression Following Targeted Genetic Manipulation of Conditionally Immortalized Muscle Precursor Cells. Exptl. Cell Res. 253 , 523-532. Abstract. Peckham, M., Wells, C., Taylor-Harris, P., Coles, D., Zicha, D. & Dunn, G.A. (1998) Using molecular genetics as a tool in understanding crawling cell locomotion in myoblasts. Biochem.Soc.Symp 65. 281-299. Abstract. Clark, P., Coles, D. & Peckham, M . (1997) Preferential Adhesion to, and survival on patterned laminin organises myogenesis in vitro. Experimental Cell Research , 230, 275-283. Abstract . Wells, C., Coles, D., Entwistle, A. & Peckham, M. (1997) Myogenic Cells express multiple myosin isoforms. J. Mus. Res.& Cell. Motil . , 18 , 501-515. Abstract. Peckham. M ., Young, P. & Gautel, M. (1997) Constitutive and variable regions of Z-disc of titin/connectin. Cell Structure & Function. 22, 95-101. Abstract . Peckham, M. (1997) A call to action from the lab bench. Commentary. Nature , 385, 765 Peckham, M., Ferenczi, M.A. & Irving, M. (1994) A birefringence study of changes in myosin orientation during relaxation of skinned muscle fibres induced by photolytic ATP release. Biophys. J. 67, 1141-1148 Morgan, J.E., Beauchamp, J.R., Pagel, C.N., Peckham, M., Ataliotis, P., Jat, P.S., Noble, M.D., Farmer, K. & Partridge, T.A. (1994) Myogenic cell lines derived from transgenic mice carrying a thermolabile T-antigen: a model system for derivation of tissue specific and mutation specific cell lines. Dev. Biol. 162, 486-498 Noble, M., A.K. Groves, P. Ataliotis, J. Morgan, M. Peckham, T. Partridge & P.S. Jat. (1993) Biological and molecular approaches to the generation of conditionally immortal neural cells. Neuroprotocols. 3, 189-200. Academic Press, Inc. Peckham, M., Cripps, R., White, D.C.S. & Bullard, B. (1992) Mechanics and Protein content of Insect flight muscles J. exp. Biol. 168, 57-76 Peckham, M. & White, D.C.S. Mechanical properties of demembranated flight muscle fibres from dragonfly. J. exp. Biol. 159, 135-147 (1991) Drummond, D.R., Peckham, M., Sparrow, J.C. & White, D.C.S. (1990) Alteration in cross-bridge kinetics caused by mutations in actin. Nature 248, 440-442 Peckham, M., Molloy, J.E., Sparrow, J.C. & White, D.C.S. (1990) Physiological properties of the dorsal longitudinal flight muscle and the tergal depressor of the trochanter muscle of Drosophila melanogaster. Journal of Muscle Research and Cell Motility. 11, 203-215 Peckham, M. & Irving, M. (1989) Myosin crossbridge orientation in demembranated muscle fibres studied by birefringence and X-ray diffraction measurements. J. Mol. Biol. 210, 113-126 Peckham, M. & Woledge, R.C. (1986) Labile heat and changes in rate of relaxation of frog muscles. J. Physiol. 374, 123-135 Elzinga, G., Peckham, M. & Woledge, R.C. (1984)The sarcomere length dependence of the rate of heat production during isometric tetan-ic contraction of frog muscles. J. Physiol. 357, 495-504 |
CV
BSc Department of Biology, University of York, 1977-1981
PhD Department of Physiology, University College London, 1981-1984
Postdoctoral Fellow, Department of Biophysics, King's College London, 1985-1987
Visiting Assistant Professor, CVRI, UCSF, San Francisco, USA, 1987-1988
Postdoctoral Fellow, Department of Biology, University of York, 1988-1990
Royal Society University Research Fellow, Randall Institute, King's College London. 1990 to 1997.
Lecturer, School of Biomedical Sciences, University of Leeds, 1997-2003
Senior Lecturer, School of Biomedical Sciences, University of Leeds, 2003-2006
Reader in Cell Biology, IMCB, Faculty of Biological Sciences, 2006-