Faculty of Biological Sciences

Publications from the Whitehouse laboratory

2017

  1. Hughes, D.J.,  Tiede, C.,  Penswick, N.,  Tang, A.A.S., Trinh, C.H., Mandal, U., Zajac, K.Z., Gaule, T., Howell, G., Edwards, T.A., Duan, J., Feyfant, E., McPherson, M.J., Tomlinson, D.C. & Whitehouse, A. (2017). Generation of specific inhibitors of SUMO1- and SUMO2/3-mediated protein-protein interactions using Affimer (Adhiron) technology. Science Signalling, In Press.
  2. Antanaviciute, A., Baquero-Perez, B., Watson, C.M., Harrison, S.M., Lascelles, C., Crinnion, L., Markham, A.F., Bonthron, D.T., Whitehouse, A. & Carr, I.M. (2017). m6aViewer: software for the detection, analysis and visualisation of N6-methyl-adenosine peaks from m6A-seq/ME-RIP sequencing data. RNA, 23, 1493–1501.
  3. Abdul-Sada, H., Bhardwaj, R., Toth, R., Arthur, J.S.C., Whitehouse, A. & Macdonald, A. (2017). The PP4R1 sub-unit of protein phosphatase PP4 is essential for inhibition of NF-ĸB by Merkel Polyomavirus small Tumour antigen. Oncotarget, 8, 25418-25432.

2016

  1. Schumann, S., Jackson, B.R., Yule, I., Whitehead, S.K., Foster, R. & Whitehouse, A. (2016). Targeting the ATP-dependent formation of herpesvirus ribonucleoprotein particle assembly as an antiviral approach. Nature Microbiology, 2:16201.
  2. Wood, J.J., Boyne, J.R., Paulus, C., Jackson, B.R., Nevels, M.M., Whitehouse, A. & Hughes, D.J. (2016). ARID3B: A novel regulator of the Kaposi’s sarcoma-associated herpesvirus lytic cycle. Journal of Virology, 90, 9543-9555.
  3. Schumann, S., Baquero-Perez, B. & Whitehouse, A. (2016). Interactions between KSHV ORF57 and the novel human TREX proteins, CHTOP and CIP29. Journal of General Virology, 97, 1904-10.

2015

  1. Hughes, D.J., Wood, J.J., Jackson, B.R., Baquero-Perez, B. & Whitehouse, A. (2015). NEDDylation is essential for Kaposi's sarcoma-associated herpesvirus latency and lytic reactivation and represents a novel anti-KSHV target. PLoS Pathogens, 11(3):e1004771.
  2. Baquero-Perez, B. & Whitehouse, A. (2015). Hsp70 isoforms are essential for the formation of KSHV replication and transcription compartments. PLoS Pathogens, 11(11):e1005274.
  3. Whitehouse, A. & Macdonald, A. (2015). Stathmin drives virus-induced metastasis. Oncotarget, 6, 32289-32290.
  4. Knight, L.M., Stakaityte, G., Wood, J.J., Griffiths, D.A., Howell, G.J., Abdul-Sada, H., Wheat, R., Blair, G.E., Macdonald, A., Blackbourn, D.J. & Whitehouse, A. (2015). Merkel cell polyomavirus small T antigen mediates microtubule destabilisation to promote cell motility and migration. Journal of Virology, 89, 35-47.
  5. Liu, L., Lear, Z., Hughes, D.J., Wu, W., Zhou, E.M., Whitehouse, A., Chen, H. & Hiscox, J.A. (2015). Resolution of the cellular proteome of the nucleocapsid protein from a highly pathogenic isolate of porcine reproductive and respiratory syndrome virus identifies PARP-1 as a cellular target whose interaction is critical for virus biology. Vet Micro., 176, 109-19.

2014

  1. Jackson, B.R., Norenberg, M. & Whitehouse, A. (2014). A novel mechanism inducing genomic instability in Kaposi’s sarcoma-associated herpesvirus infected cells. PLoS Pathogens, 10(5): e1004098.
  2. Stakaityte, G., Wood, J.J., Knight, L.M., Abdul-Sada, H., Azdahar, N.S., Nwogu, N., Macdonald, A. & Whitehouse, A. (2014). Merkel cell polyomavirus: insights into the mostly discovered human tumour virus. Cancers, 6, 1267-1297.
  3. Owen, C.B., Hughes, D,J., Baquero-Perez, B., Berndt, A., Schumann, S., Jackson, B.R. & Whitehouse, A. (2014). Utilising proteomic approaches to understand oncogenic herpesviruses. Molecular and Clinical Oncology, 2, 891-903.
  4. Akhbari, P., Whitehouse, A. & Boyne, J.R. (2014). Long non-coding RNAs drive metastatic progression in melanoma. Int J Oncol. 45, 2181-2186.

2013

  1. Brown, H.F., Unger, C. & Whitehouse, A. (2013). Potential of Herpesvirus saimiri-based vectors to generate induced pluripotent cancer stem cells. Journal of Virology, 87, 7127-7139.
  2. Emmott, E., Munday, D., Bickerton, E., Britton, P., Rodgers, M.A., Whitehouse, A., Zhou, E.M. & Hiscox, J.A. (2013). The cellular interactome of the coronavirus infectious bronchitis virus nucleocapsid protein and functional implications for virus biology. Journal of Virology, 87, 9486-9500.
  3. Griffiths, D.A., Abdul-Sada, H., Knight, L.M., Jackson, B.R., Richards, K., Prescott, E.L., Peach, A.H.S., Blair, G.E., Macdonald, A. &  Whitehouse, A. (2013). Merkel cell polyomavirus small T antigen targets the NEMO adaptor protein to disrupt inflammatory signalling. Journal of Virology, 87:24 13853-13867.
  4. Schumann, S., Jackson, B.R., Baquero-Perez, B. & Whitehouse, A. (2013). Kaposi’s sarcoma-associated herpesvirus ORF57 protein: exploiting all stages of viral mRNA processing. Viruses, 5, 1901-23.
  5. Ingram, N., Macnab, S.A., Marston, G., Scott, N., Carr, I.M., Markham, A.F., Whitehouse, A. & Coletta, P.L. (2013). The use of high-frequency ultrasound imaging and biofluorescence for in vivo evaluation of gene therapy vectors. BMC Medical Imaging, 13:35.

2012

  1. Turrell, S,J., Filby, M.H., Whitehouse A. & Wilson, A.J. (2012). Cellular Uptake of Highly-Functionalized Ruthenium(II) tris-Bipyridine Protein-Surface Mimetics. Bioorganic & Medicinal Chemistry Letters, 15, 985-988.
  2. Munday DC, Surtees R, Emmott E, Dove BK, Digard P, Barr JN, Whitehouse A, Matthews D, Hiscox JA. (2012). Using stable isotope labeling with amino acids in cell culture (SILAC) and quantitative proteomics to investigate the interactions between viruses and viral proteins and host cells. Proteomics, 12, 666-672.
  3. Turrell, S.J.,  Macnab, S.A., Rose, A., Melcher. A.A. & Whitehouse, A. (2012). A Herpesvirus Samiri-based vector expressing TRAIL induces cell death in human carcinoma cell lines and multicellular spheroid cultures. International Journal of Oncology, 40, 2081-2089.
  4. Jackson, B.R., Norenberg, M. & Whitehouse, A. (2012). The Kaposi’s sarcoma-associated herpesvirus ORF57 protein and its multiple roles in mRNA biogenesis. Future Microbiol., 3, 59.
  5. Dyson, O., Walker, L., Whitehouse, A., Cook, P. & Akula, S,M. (2012). Resveratrol inhibits KSHV reactivation by lowering the levels of cellular EGR-1. PLoS One, 7(3), e33364.

2011

  1. Tunnicliffe, R.B., Hautbergue, G. M., Kalra, P., Jackson, B.R., Whitehouse, A., Wilson, S.A. & Golovanov, A.P. (2011). Structural basis for the recognition of cellular mRNA export factor REF by herpes viral proteins HSV-1 ICP27 and HVS ORF57. PLoS Pathogens, 7(1), e1001244.
  2. Jackson, B.R., Boyne, J.R., Norenberg, M., Taylor, A., Hautbergue, G.M., Walsh, M.J., Wheat, R., Blackbourn, D.J., Wilson, S.A. & Whitehouse, A. (2011). An interaction between KSHV ORF57 and UIF provides mRNA-adaptor redundancy in herpesvirus intronless mRNA export. PLoS Pathogens, 7(7), e1002138.
  3. Taylor, A., Jackson, B.R., Noerenberg, M., Hughes, D.J., Boyne, J.R., Verow, M., Harris, M. & Whitehouse, A. (2011). Mutation of a C-terminal motif affects KSHV ORF57 RNA binding, nuclear trafficking and multimerisation. Journal of Virology, 85, 7881-7891.
  4. Hong, Y., Macnab, S., Dawson, L.A., Turner, A.J., Whitehouse, A. & Usmani, B.A. (2011). HVS-based ECE-1 siRNA expression decreases prostate cancer cell invasion and migration. International Journal of Cancer, 129, 586-598.
  5. Turrell, S.J. & Whitehouse, A. (2011). Mutation of Herpesvirus saimiri ORF51 glycoprotein specifically targets infectivity to Hepatocellular Carcinoma cell lines. Journal of Biomedicine and Biotechnology, 2011 : 785158.
  6. Macnab, S., Turrell, S.J., Carr, I.M., Markham, A.F., Coletta. P.L. & Whitehouse, A. (2011). Herpesvirus saimiri-mediated delivery of the adenomatous polyposis coli tumour suppressor gene reduces proliferation of colorectal cancer cells. International Journal of Oncology, 39, 1173-1181.
  7. Khandelwal, N., Simpson, J., Taylor, G., Rafique, S., Clarke, C., Whitehouse, A., Hiscox, J.A. & Stark, L.A. (2011). Nucleolar NF-kB/RelA promotes apoptosis by causing cytoplasmic  relocalisation of nucleophosmin(B23). Cell Death and Differentiation,18, 1889-1903.
  8. Whitehouse A. (2011). Production of recombinant Herpesvirus saimiri-based vectors. Cold Spring Harb Protoc. 12, 1515-1519.
  9. Whitehouse A. (2011). Assessment of infectivity using a Herpesvirus saimiri (HVS) recombinant that expresses HVS-GFP. Cold Spring Harb Protoc. 12, 1520-1523.
  10. Whitehouse A.(2011). Gardella gel analysis to detect Herpesvirus saimiri episomal DNA. Cold Spring Harb Protoc. 12, 1524-6.

2010

  1. Boyne, J.R., Jackson, B.R., Taylor, A., Macnab, S.A. & Whitehouse, A. (2010). Kaposi's sarcoma-associated herpesvirus ORF57 interacts with PYM to enhance viral intronless mRNA translation. EMBO Journal, 29, 1851-1864.
  2. Boyne, J.R., Jackson, B.R. & Whitehouse, A. (2010). KSHV ORF57 : Master regulator of mRNA biogenesis. Cell Cycle, 9, 2702-2703.
  3. Hiscox, J.A., Whitehouse, A. & Matthews, D.A. (2010). Nucleolar proteomics and viral infection. Proteomics, 10, 4077-4086.

2009

  1. Gao, J., Coulson, J.M., Whitehouse, A. & Blake, N. (2009). Reduction in RNA levels rather than retardation of translation is responsible for the inhibition of MHC Class I antigen presentation by the glutamic acid rich repeat of Herpesvirus saimiri ORF73. Journal of Virology, 83, 273-282.
  2. Gould, F., Harrison, S.M., Hewitt, E.W. & Whitehouse, A. (2009). Kaposi's sarcoma-associated herpesvirus (KSHV) Rta promotes degradation of the Hey1 repressor protein through the ubiquitin proteasome pathway. Journal of Virology, 83, 6727-6738.
  3. Colgan, K.J., Boyne, J.R. & Whitehouse, A. (2009). Identification of a response element in a herpesvirus saimiri mRNA recognised by the ORF57 protein. Journal of General Virology, 90, 596-601.
  4. Colgan, K.J., Boyne, J.R. & Whitehouse, A. (2009). Uncoupling of hTREX components demonstrates that UAP56 and hTHO-complex recruitment onto herpesvirus saimiri intronless transcripts is required for replication. Journal of General Virology, 90, 1455 - 1460.
  5. Macnab, S. & Whitehouse, A. (2009). Progress and prospects: Artificial chromosomes. Gene Therapy, 16, 1180-1188.
  6. Boyne, J.R. & Whitehouse, A. (2009). Nucleolar disruption impairs Kaposi’s sarcoma-associated herpesvirus ORF57-mediated nuclear export of intronless viral mRNAs. FEBS Letters, 583, 3549-56.

2008

  1. Boyne, J.R., Colgan, K.J. & Whitehouse, A. (2008). hTREX complex recruitment to Kaposi's sarcoma-associated herpesvirus intronless mRNA is essential for nuclear export. PLoS Pathogens, 4(10):e1000194.
  2. Harrison, S.M. & Whitehouse, A.(2008). Kaposi’s sarcoma associated herpesvirus (KSHV) Rta and cellular HMGB1 proteins synergistically transactivate the KSHV ORF50 promoter. FEBS Letters, 50, 3080-3084.
  3. Macnab, S., White, R.E., Hiscox, J.A. & Whitehouse, A. (2008). Production of an infectious Herpesvirus saimiri-based episomally maintained amplicon system. Journal of Biotechnology, 134, 287-296.
  4. Boyne, J.R. Colgan, K.J. & Whitehouse, A. (2008). Herpesvirus saimiri ORF57: a post-transcriptional regulatory protein. Frontiers in Bioscience, 13, 2928-2938.
  5. Griffiths, R., Harrison, S.M., Macnab, S. & Whitehouse, A. (2008). Mapping the minimal regions within the ORF73 protein required for Herpesvirus saimiri episomal persistence. Journal of General Virology, 89, 2843 – 2850.
  6. Emmott, E., Dove, B.K., Howell, G., Chappell, L., Reed, M.L., Boyne, J.R., You, J.H., Brooks, G., Whitehouse, A. & Hiscox, J.A. (2008). Viral nucleolar localisation signals determine dynamic trafficking within the nucleolus. Virology, 380, 191-202.

2007

  1. Griffiths, R.A. & Whitehouse, A. (2007). The interaction between ORF 73 and MeCP2 is essential for HVS episomal persistence. Journal of Virology, 81, 4021-4032.
  2. Wilson, S.J., Tsao, E., Webb, B.L., Ye, H., Dalton-Griffin, L., Tsantoulas, C., Gale, C.V., Du, D., Whitehouse, A. & Kellam, P. (2007). XBP-1 transactivates the KSHV ORF50 promoter, linking plasma cell differentiation to KSHV reactivation from latency. Journal of Virology, 81, 13578-13586.

2006

  1. Boyne, J.R. & Whitehouse, A. (2006). Nucleolar trafficking is essential for nuclear export of intronless herpesvirus mRNAs. Proc. Natl. Acad. Sciences, USA, 103, 15190-15195.
  2. Boyne, J.R. & Whitehouse, A. (2006). Gamma-2 herpesvirus post-transcriptional gene regulation. Clinical Microbiology and Infection, 12, 110-117.
  3. Whitehouse, A. (2006). Gamma-2 Herpesvirus saimiri-based vectors, p 255-264. In Gene Transfer: Delivery and expression of DNA and RNA, a laboratory manual. Cold Spring Harbor Laboratory Press.
  4. Griffiths, R.A., Boyne, J.R. & Whitehouse, A. (2006). Herpesvirus saimiri-based gene delivery vectors. Current Gene Therapy, 6, 1-15.

2005

  1. Williams, B., Boyne, J.R., Goodwin, D.J., Roaden, L.R., Wilson, S.A. & Whitehouse, A. (2005). The prototype gamma-2 herpesvirus nucleocytoplasmic shuttle protein, ORF 57,  transports viral RNA via the cellular mRNA export pathway. Biochemical Journal, 387, 295-308.
  2. Smith, P.G., Oakley, F., Fernandez, M., Mann, D., Lemoine, N.R. & Whitehouse, A. (2005). Herpesvirus saimiri-based vector biodistribution using non-invasive optical imaging. Gene Therapy, 12, 1465-1476.
  3. Wakenshaw, L., Walters, M.S. & Whitehouse, A. (2005). Herpesvirus saimiri Rta and cEBPa act synergistically to activate the DNA polymerase promoter. Journal of Virology, 79, 13548-13560.
  4. Walters, M.S. Hall, K.T. & Whitehouse, A. (2005). The herpesvirus saimiri Rta protein autostimulates via binding to a non-consensus response element. Journal of General Virology, 86, 581-587.
  5. Smith, P.G., Burchill, S.A., Brooke, D., Coletta, P.L. & Whitehouse, A. (2005). Efficient infection and persistence of a HVS-based gene delivery vector into human tumour xenografts and multicellular spheroid cultures. Cancer Gene Therapy, 12, 248-256.
  6. Calderwood, M.A., White, R.E. Griffiths, R.A. & Whitehouse, A. (2005). Open reading frame 73 is required for Herpesvirus saimiri All-S4 episomal persistence. Journal of General Virology, 86, 2703-2708.

2004

  1. Walters, M.S., Hall, K.T. & Whitehouse, A. (2004). The HVS ORF 50 (Rta) Protein encodes an AT-Hook required for binding to the ORF 50 Response Element in delayed early promoters. Journal of Virology, 78, 4936-4942.
  2. Calderwood, M.A., Hall, K.T., Matthews, D.A. & Whitehouse, A. (2004). The Herpesvirus saimiri ORF 73 protein co-localises with host cell mitotic chromosomes and self associates via its C-terminus. Journal of General Virology, 85, 147-153.
  3. Calderwood, M.A. White, R.E. & Whitehouse, A. (2004). Development of herpesvirus-based episomally maintained gene delivery vectors. Expert Opinion on Biological Therapy, 4, 493-505.

2003

  1. Giles, M.S., Smith, P.G., Coletta, P.L., Hall, K.T. & Whitehouse, A. (2003). HVS ORF 73 regulatory region provides long term transgene expression in human carcinoma cell lines. Cancer Gene Therapy, 10, 49-56.
  2. Whitehouse, A. (2003). Herpesvirus saimiri: a potential gene delivery vector. International Journal of Molecular Medicine, 11, 139-148.
  3. Goodwin, D.J., Walters, M.S. & Whitehouse, A. (2003). Gene regulation in the prototype gamma-2 herpesvirus. Current Topics in Virology, 3, 33-52.
  4. White, R.E. Calderwood, M.A. & Whitehouse, A. (2003). Generation and precise modification of a herpesvirus saimiri BAC demonstrates that the terminal repeats are required for both virus production and episomal persistence. Journal of General Virology, 84, 3393-3403.

2002

  1. Hall, K.T., Giles, M.S., Calderwood, M.A., Goodwin, D.J., Matthews, D.A. &  Whitehouse, A. (2002). The Herpesvirus saimiri ORF 73 gene product interacts with the cellular protein, p32. Journal of Virology, 76, 11612-11622.

2001

  1. Goodwin, D.J., Walters, M.S., Smith, P.G., Thurau, M., Fickenscher, H. & Whitehouse, A. (2001). The Herpesvirus saimiri Rta / ORF 50 protein reactivates the lytic replication cycle in a persistently infected A549 cell line. Journal of Virology 75, 4008-4013.
  2. Goodwin, D.J. & Whitehouse, A. (2001). A gamma-2 herpesvirus nucleocytoplasmic shuttle protein interacts with importin a-1 and importin a-5. Journal of Biological Chemistry, 276, 19905-19912.
  3. Smith, P.G., Coletta, P.L. Markham, A.F. & Whitehouse, A. (2001). In vivo episomal maintenance of a herpesvirus saimiri-based gene delivery vector. Gene Therapy, 8, 1762-1769.

2000

  1. Hall, K.T., Giles, M.S., Goodwin, D.J., Calderwood, M.A., Carr, I.M., Stevenson, A.J., Markham, A.F. &  Whitehouse, A. (2000). Analysis of gene expression in a human cell line stably transduced with Herpesvirus saimiri. Journal of Virology 74, 7331-7337.
  2. Stevenson, A.J., Clarke, D., Meredith, D.M., Kinsey, S.E., Whitehouse, A. & Bonifer, C. (2000). Herpesvirus saimiri-based gene therapy vectors maintain heterologous expression throughout mouse embryonic stem cell differentiation in vitro. Gene Therapy  7, 464-471.
  3. Thurau, M., Whitehouse A., Wittmann, S., Meredith, D.M. & Fickenscher, H. (2000). Distinct transcriptional and functional properties of the R transactivator gene, ORF 50, of the transforming Herpesvirus saimiri strain C488. Virology 268, 167-177.
  4. Stevenson, A.J., Frolova-Jones, E., Hall, K.T., Kinsey, S.E., Markham, A.F., Whitehouse, A. & Meredith, D.M. (2000). A Herpesvirus saimiri-based gene therapy vector with potential for use in cancer immunotherapy. Cancer Gene Therapy 7, 1077-1085.
  5. Goodwin, D.J., Hall, K.T., Giles, M.S., Calderwood, M.A., Markham, A.F. & Whitehouse, A. (2000). The carboxy-terminus of the Herpesvirus saimiri ORF 57 gene contains domains that are required for transactivation and transrepression. Journal of General Virology 81, 2253-2265.
  6. Hall, K.T., Giles, M.S., Goodwin, D.J., Calderwood, M.A., Markham, A.F. & Whitehouse, A. (2000). Characterisation of the Herpesvirus saimiri ORF 73 gene product. Journal of General Virology 81, 2653-2658.
  7. Stevenson, A.J., Giles, M.S., Hall, K.T., Goodwin, D.J., Calderwood, M.A., Markham, A.F. & Whitehouse, A. (2000). Specific oncolytic activity of Herpesvirus saimiri in pancreatic cancer cells. British Journal of Cancer 83, 329-332.

1999

  1. Hall, K.T., Stevenson, A.J., Goodwin, D.J., Gibson, P.C., Markham, A.F. &  Whitehouse, A. (1999). The activation domain of the Herpesvirus saimiri R protein interacts with the TATA-binding protein. Journal of Virology 73, 9756-9763.
  2. Goodwin, D.J., Hall, K.T., Stevenson, A.J., Markham, A.F. & Whitehouse, A. (1999). The ORF 57 gene product of Herpesvirus saimiri shuttles between the nucleus and cytoplasm and is involved in viral RNA nuclear export. Journal of Virology 73, 10519-10524.
  3. Cooper, M., Goodwin, D.J., Hall, K.T., Stevenson, A.J., Meredith, D.M., Markham, A.F. & Whitehouse, A. (1999). The gene product encoded by ORF 57 of HVS regulates the redistribution of the splicing factor, SC-35. Journal of General Virology 80, 1311-1316. 
  4. Bello, L.J., Davison, A.J., Glenn, M., Whitehouse, A. Rethmeier, N., Schulz, T.F. & Clements, J.B. (1999). The human herpesvirus type-8 ORF 57 gene and its properties. Journal of General Virology  80, 3207-3215.
  5. Whitehouse, A. & Meredith, D.M. (1999). Identification and analysis of transacting proteins involved in the regulation of DNA virus gene expression, p. 157-175. In DNA viruses: A Practical Approach, Oxford University Press.
  6. Whitehouse, A. & Stevenson, A.J. (1999). Gene regulation in Herpesvirus saimiri and its implication towards the development of a novel gene therapy vector. Gene Therapy and Molecular Biology 3, 35-44.
  7. Stevenson, A.J., Cooper, M., Griffiths, J.C., Gibson, P.G., Whitehouse, A., Jones, E.F., Kinsey, S.E., Markham, A.F. & Meredith, D.M. (1999). Assessment of Herpesvirus saimiri as a potential human gene therapy vector. Journal of Medical Virology 57, 269-277.

1998

  1. Whitehouse, A., Cooper, M. & Meredith, D.M. (1998). The IE gene product encoded by ORF 57 of Herpesvirus saimiri  modulates gene expression at a post-transcriptional level. Journal of Virology 72, 857-861.
  2. Whitehouse, A., Cooper, M., Hall, K.T. & Meredith, D.M. (1998). The ORF 50a gene product regulates ORF 57 gene expression in Herpesvirus saimiri. Journal of Virology 72, 1967-1973.
  3. Whitehouse, A., Meredith, D.M. & Markham, A.F. (1998). Mismatch repair genes and their association with colorectal cancer. International Journal of Molecular Medicine 1, 469-474.
  4. Carr, I.M., Whitehouse, A., Coletta, P.L. & Markham, A.F. (1998). Characterisation of the human sorbitol dehydrogenase gene duplication by evolutionary comparison with the marmoset sequence. Mammalian Genome 9, 1042-1048.

1997

  1. Whitehouse, A., Carr, I.M., Griffiths, J.C. & Meredith, D.M. (1997). The herpesvirus saimiri ORF 50 gene encoding a major transcriptional activator homologous to the EBV R protein, is transcribed from two distinct promoters of different temporal phases. Journal of Virology 71, 2550-2554. 
  2. Whitehouse, A., Stevenson, A.J., Cooper, M. & Meredith, D.M. (1997).  Identification of a cis-acting element within the herpesvirus saimiri ORF6 promoter that is responsive to the HVS.R transactivator. Journal of General Virology 78, 1411-1415.
  3. Whitehouse, A., Deeble, J., Taylor, G.R., Guillou, P.J., Phillips, S.E.V., Meredith, D.M. & Markham, A.F. (1997).  Mapping the minimal domain of hMSH2 sufficient for binding mismatched oligonucleotides. Biochem. Biophys. Res. Commun. 232, 10-13.
  4. Whitehouse, A., Deeble, J., Parmar, R., Taylor, G.R., Markham, A.F. & Meredith, D.M. (1997).  Analysis of the mismatch and insertion/deletion binding properties of Thermus thermophilus, HB8, MutS.  Biochem. Biophys. Res. Commun. 233, 834-837.

1996

  1. Whitehouse, A., Taylor, G.R., Deeble, J., Phillips, S.E.V., Meredith, D.M. & Markham, A.F. (1996).  A carboxy terminal domain of the hMSH2 gene product is sufficient for binding specific mismatched oligonucletides.  Biochem. Biophys. Res. Commun. 225, 289-295.
  2. Whitehouse, A., Parmar, R., Deeble, J., Taylor, G.R., Phillips, S.E.V., Meredith, D.M. & Markham, A.F. (1996). Mutational analysis of the nucleotide binding domain of the mismatch repair enzyme, hMSH2. Biochem. Biophys. Res. Commun. 229, 147-153.
  3. Norris, A.L., Bailey, A., Askham, J., Whitehouse, A., Clissold, P.M., Markham, A.F. & Meredith, D.M. (1996). Characterization of the human B catenin gene. Mammalian Genome 7, 160-162