Research in our laboratory is focused on ion channels, a family of membrane proteins that control the flow of ions across the cell membrane. Without ion channels many of the body functions come to a complete halt: our brains stop sending signals, our hearts stop beating, our vessels stop pumping blood, our glands stop secreting hormones, and our limbs stop moving. Consequently, defects in the function of ion channels lead to diseases such as epilepsy, cardiac arrhythmias, kidney dysfunction and diabetes. Ion channels therefore represent important drug targets.
Our laboratory is interested in understanding (i) how ion channels work at the molecular level and (ii) how they are made and transported to and out of their site of action. Through these studies, we hope to improve our understanding of human diseases and to develop new strategies to disease treatment.