Recent Publications
2008
Bland ND, Pinney JW, Thomas JE, Turner AJ, & Isaac RE. (2008) BMC Evol. Biol. 8:16. Bioinformatic analysis of the neprilysin (M13) family of peptidases reveals complex evolutionary and functional relationships.
Dupiereux, I., Falisse-Poirrier, N., Zorzi, W., Watt, N.T., Thellin, O., Zorzi, D., Pierard, O., Hooper, N.M., Heinen, E. & Elmoualij, B. (2008) J. Neurosci. Res. 86, 653-659. Protective effect of prion protein via the N-terminal region in mediating a protective effect on paraquat-induced oxidative injury in neuronal cells.
Garner, A.E., Smith, D.A. & Hooper, N.M. (2008) Biophys. J. 94, 1326-1340. Visualisation of detergent solubilisation of membranes: implications for the isolation of rafts.
Griffiths, H.H., Morten, I.J. & Hooper, N.M. (2008) Expert Opin. Ther. Targets 12, 693-704. Emerging and potential therapies for Alzheimer’s disease.
Hooper, N.M. & Turner, A.J. (2008) Trends Biochem. Sci. 33, 151-155. A new take on prions: preventing Alzheimer’s disease.
Lambert, D.W., Clarke, N.E., Hooper, N.M. & Turner, A.J. (2008) FEBS Lett. 582, 385-390. Calmodulin interacts with angiotensin-converting enzyme-2 (ACE2) and inhibits shedding of its ectodomain.
Lambert, D.W., Hooper, N.M. & Turner, A.J. (2008) Biochem. Pharmacol. 75, 781-786. Angiotensin-converting enzyme 2 and new insights into the renin-angiotensin system.
Wilkinson, D.K., Turner, E.J., Parkin, E.T., Garner, A.E., Harrison, P.J., Crawford, M., Stewart, G.W. & Hooper, N.M. (2008) Biochim. Biophys. Acta 1778, 125-132. Membrane raft actin deficiency and altered Ca2+-induced vesiculation in stomatin-deficient overhydrated hereditary stomatocytosis.
2007
Fisk L, Nalivaeva NN, Boyle JP, Peers CS, &Turner AJ. (2007) Neurochem. Res. 32, 1741-1748. Effects of hypoxia and oxidative stress on expression of neprilysin in human neuroblastoma cells and rat cortical neurones and astrocytes.
Fisk L, Nalivaeva NN, & Turner AJ. (2007) Exp. Biol. Med. 231, 1048-1053. Regulation of endothelin-converting enzyme-1 expression in human neuroblastoma cells.
Garner, A.E., Smith, D.A. & Hooper, N.M. (2007) Mol. Membr. Biol. 24, 233-242. Sphingomyelin chain length influences the distribution of GPI-anchored proteins in rafts in supported lipid bilayers.
Hamming, I., Cooper, M.E., Haagmans, B.L., Hooper, N.M., Korstnje, R., Osterhaus, A.D.M.E., Timens, W., Turner, A.J., Navis, G. & van Goor, H. (2007) J. Pathol. 212, 1-11. The emerging role of ACE2 in physiology and disease.
Parkin, E.T., Watt, N.T., Hussain, I., Eckman, E.A., Eckman, C.B., Manson, J.C., Baybutt, H.N., Turner, A.J. & Hooper, N.M. (2007) Proc. Natl. Acad. Sci USA 104, 11062-11067. Cellular prion protein regulates b-secretase cleavage of the Alzheimer’s amyloid precursor protein.
Rella, M., Elliot, J.L., Revett, T.J., Lanfear, J., Phelan, A., Jackson, R.M., Turner, A.J. & Hooper, N.M. (2007) BMC Genomics 8, 194 (doi:10.1186/1471-2164-8-194) Identification and characterisation of the angiotensin converting enzyme-3 (ACE3) gene: a novel mammalian homologue of ACE.
Say, Y.-H. & Hooper, N.M. (2007) Proteomics 7, 1059-1064. Contamination of nuclear fractions with plasma membrane lipid rafts.
Taylor, D.R. & Hooper, N.M. (2007) Biochem. J. 402, 17-23. The low-density lipoprotein receptor-related protein 1 (LRP1) mediates the endocytosis of the cellular prion protein.
Taylor, D.R. & Hooper, N.M. (2007) Sem. Cell Develop. Biol. 18, 638-648. Role of lipid rafts in the processing of the pathogenic prion and Alzheimer’s amyloid-b proteins.
Vardy, E.R.L.C., Rice, P.J., Bowie, P.C.W., Holmes, J.D., Grant, P.J. & Hooper, N.M. (2007) J. Alzheimer’s Dis. 12, 285-290. Increased circulating insulin-like growth factor-1 in late-onset Alzheimer’s disease.
Watt, N.T., Routledge, M.N., Wild, C.P. & Hooper, N.M. (2007) Free Rad. Biol. Med. 43, 959-967. Cellular prion protein protects against reactive-oxygen-species-induced DNA damage.
Yoon, H.J., Park, S.W., Lee, H.B., Im, S.Y., Hooper, N.M. & Park, H.S. (2007) Arch. Pharm. Res. 30, 608-615. Release of renal dipeptidase from glycosylphosphatidylinositol anchor by insulin-triggered phospholipase C/intracellular Ca2+.
2006
Alfalah, M., Krahn, M.P., Wetzel, G., von Hörsten, S., Wolke, C., Hooper, N.M., Kalinski, T., Krueger, S., Naim, H.Y. & Lendeckel, U. (2006) J. Biol. Chem. 281, 11894-11900. A mutation in aminopeptidase N (CD13) isolated from a patient suffering from leukaemia leads to an arrest in the endoplasmic reticulum.
Awano, S., Dawson, L.A., Hunter, A.R., Turner, A.J. & Usmani, B.A. (2006) Int. J. Cancer 118, 1645-1652. Endothelin system in oral squamous carcinoma cells: specific siRNA targeting of ECE-1 blocks cell proliferation.
Cordy, J.M., Hooper, N.M. & Turner, A.J. (2006) Mol. Membr. Biol. 23, 111-122. The involvement of lipid rafts in Alzheimer’s disease (review).
Omaetxebarria, M.J., Hagglund, P., Elortza, F., Hooper, N.M., Arizmendi, J.M. & Jensen, O.N. (2006) Anal. Chem. 78, 3335-3341. Isolation and characterization of glycosylphosphatidylinositol-anchored peptides by hydrophilic interaction chromatography and MALDI tandem mass spectrometry.
Rice, G.I., Jones, A.L., Grant, P.J., Carter, A.M., Turner, A.J. & Hooper, N.M. (2006) Hypertension 48, 914-920. Circulating activities of angiotensin-converting enzyme, its homolog, angiotensin-converting enzyme 2, and neprilysin in a family study.
Taylor, D.R. & Hooper, N.M. (2006) Mol. Membr. Biol. 23, 89-99. The prion protein and lipid rafts (review).
Thomas, D.A., Francis, P., Smith, C., Ratcliffe, S., Ede, N.J., Kay, C., Wayne, G., Martin, S.L., Moore, K., Amour, A. & Hooper, N.M. (2006) Proteomics 6, 2112-2120. A broad-spectrum fluorescence-based peptide library for the rapid identification of protease substrates.
Vardy, E.R.L.C., Hussain, I. & Hooper, N.M. (2006) Expert Rev. Neurotherapeutics 6, 695-704. Emerging therapeutics for Alzheimer’s disease.
Wallace, E.J., Hooper, N.M. & Olmsted, P.D. (2006) Biophys. J. 90, 4104-4118. Effect of hydrophobic mismatch on phase behaviour of lipid membranes.
2005
Guy, J.L., Jensen., H., Hooper, N.M. & Turner, A.J. (2005) FEBS J. 272, 3512-3520. Identification of critical active-site residues in angiotensin-converting enzyme-2 (ACE2) by site-directed mutagenesis.
Guy, J.L., Lambert, D.W., Warner, F.J., Hooper, N.M. & Turner, A.J. (2005) Biochim. Biophys. Acta 1751, 2-8. Membrane-associated zinc peptidase families: comparing ACE and ACE2.
Hames, B.D. & Hooper, N.M. (2005) Instant Notes Biochemistry, 3rd edition, Taylor & Francis, Oxford, pp.438.
Hooper, N.M. (2005) Biochem. Soc. Trans. 33, 335-338. Roles of proteolysis and lipid rafts in the processing of the amyloid precursor protein and prion protein.
Hooper, N.M. (2005) GPI anchors, in: Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics, John Wiley & Sons, DOI: 10.1002/047001153X.g305209
Hooper, N.M. & Lendeckel, U. (2005) The ADAM Family of Proteases (Proteases in Biology and Disease, Vol. 4), Springer, New York, pp.344.
Lambert, D.W., Yarski, M., Warner, F.J., Thornhill, P., Parkin, E.T., Smith, A.I., Hooper, N.M. & Turner, A.J. (2005) J. Biol. Chem. 280, 30113-30119. Tumor necrosis factor-a convertase (ADAM17) mediates regulated ectodomain shedding of the sever-acute respiratory syndrome-coronavirus (SARS-CoV) receptor, angiotensin-converting enzyme-2 (ACE2).
Leisle, L., Parkin, E.T., Turner, A.J. & Hooper, N.M. (2005) Nat. Med. 11, 1139-1140. Angiotensin converting enzyme as a GPIase: a critical re-evaluation.
Lendeckel, U. & Hooper, N.M. (2005) Proteases in the Brain (Proteases in Biology and Disease, Vol. 3), Springer, New York, pp.383.
McIlhinney, R.A.J. & Hooper, N.M. (2005) Lipids, Rafts and Traffic (Biochemical Society Symposium 72), Portland Press, London, pp.235.
Taylor, D.R., Watt, N.T., Perera, W.S.S. & Hooper, N.M. (2005) J. Cell Sci. 118, 5141-5153. Assigning functions to distinct regons of the N-terminus of the prion protein that are involved in its copper-stimulated, clathrin-dependent endocytosis.
Urquhart, P., Pang, S. & Hooper, N.M. (2005) Biochem. Soc. Symp. 72, 39-45. N-glycans as apical targeting signals in polarized epithelial cells.
Vardy, E.R.L.C., Catto, A.J. & Hooper, N.M. (2005) Trends Mol. Med. 11, 464-472. Proteolytic mechanisms in amyloid-b metabolism: therapeutic implications for Alzheimer’s disease.
Wallace, E. J., Hooper, N. M. & Olmsted, P. D. (2005) Biophys. J. 88, 4072-4083. The kinetics of phase separation in asymmetric membranes.
Warner, F.L., Lew, R.A., Smith, A.I., Lambert, D.W., Hooper, N.M. & Turner, A.J. (2005) J. Biol. Chem. 280, 39353-39362. Angiotensin-converting enzyme 2 (ACE2), but not ACE, is preferentially localised to the apical surface of polarised kidney cells.
Watt, N.T., Taylor, D.R., Gillott, A., Thomas, D.A., Perera, W.S.S. & Hooper, N.M. (2005) J. Biol. Chem. 280, 35914-35921. Reactive oxygen species-mediated b-cleavage of the prion protein in the cellular response to oxidative stress.
2004
Nalivaeva, N.N., Fisk, L., Kochkina, E.G., Plesneva, S.A., Zhuravin, I.A., Babusikova, E., Dobrota, D. & Turner, A.J. (2004) Ann. N.Y. Acad. Sci. 1035, 21-33. Effect of hypoxia/ischemia and hypoxic preconditioning/reperfusion on expression of some amyloid-degrading enzymes.
Turner, A.J., Fisk, L. & Nalivaeva, N.N. (2004) Ann. N.Y. Acad. Sci. 1035, 1-20. Targeting amyloid-degrading enzymes as therapeutic strategies in neurodegeneration.