Faculty of Biological Sciences

Understanding Life in Molecular Detail

The Astbury Centre for Structural Molecular Biology promotes interdisciplinary research of the highest standard on the structure and function of biological molecules, biomolecular assemblies and complexes using molecular biological, physio-chemical and computation approaches.

Research within The Astbury Centre for Structural Molecular Biology is organised around the following themes:

  • Chemical Biology
  • Structural Biology
  • Biophysics
  • Molecular interactions in cells

Members of the Centre come from across the University, with members in FBS, Chemistry, Physics, Health and Engineering. Further information on members of FBS working within the Astbury Centre can be found on the Centre's website.

Key researchers in this area

  • Struc&Mol
  • Prof Alison Ashcroft, Professor in Biomolecular Mass Spectrometry
    Mass spectrometry, Mass Spectrometry Facility Manager
    Research interests
  • Dr Julie Aspden, University Academic Fellowship in Pervasive Transcription
    RNA Biology: mRNA translation, long non-coding RNAs and RNA-binding proteins in Drosophila
    Research interests
  • Dr John Barr, Lecturer
    Structural Biology, Viral gene expression
    Research interests
  • Prof Richard Bayliss, Professor in Molecular Medicine
    Structural biology, protein kinases, cancer, drug discovery
    Research interests
  • Prof Alan Berry, Professor in Molecular Enzymology
    Protein Engineering, Directed Evolution, Molecular Enzymology, Aldolases
    Research interests
  • Dr Joan Boyes, Associate Professor
    Regulation of Gene Activity and V(D)J Recombination by Chromatin Modifications
    Research interests
  • Prof Alex Breeze, Chair in Biomolecular NMR
    Research interests
  • Dr David Brockwell, Associate Professor
    Single Molecule Mechanical Unfolding of Proteins and their Complexes
    Research interests
  • Dr Edwin Chen, University Academic Fellowship in Molecular Mechanisms of Cancer Biology
    Molecular basis and clonal evolution of myeloid malignancies
    Research interests
  • Dr Ron Chen, University Academic Fellowship in Pervasive Transcription
    Epigenetic control in transcription regulation using functional genetics and genomics
    Research interests
  • Dr Joseph Cockburn, Lecturer in Macromolecular X-ray Crystallography
    Structural Studies on molecular motors and the cytoskeleton
    Research interests
  • Dr Thomas Edwards, Associate Professor
    Structural Biology, RNA:Protein Interactions, Molecular Control of Embryogenesis
    Research interests
  • Dr Juan Fontana, University Academic Fellowship in Correlative Light and Electron Microscopy
    Structural characterization of viruses
    Research interests
  • Prof Adrian Goldman, Chair in Membrane Biology
    Research interests
  • Prof Mark Harris, Professor of Virology
    Virus-host interactions in hepatitis C virus and HIV-1 Virus-host interactions in hepatitis C virus and HIV-1
    Research interests
  • Dr Glyn Hemsworth, UAF
    Protein structure, function and application in biotechnology
    Research interests
  • Prof Peter Henderson, Professor of Biochemistry and Molecular Biology
    Membrane Proteins, Sugar Transport, Antibiotic Resistance
    Research interests
  • Dr Eric Hewitt, Senior Lecturer
    Cellular Interactions with Amyloid and Molecular Immunology
    Research interests
  • Dr Lars Jeuken, Reader in Biophysics
    Membrane Biology, Metalloenzymes, Biophysics, Electron transfer
    Research interests
  • Prof Peter Knight, Professor of Molecular Contractility
    Structural Basis of Movement in Cells and Tissues
    Research interests
  • Dr Sergei Krivov, RCUK Academic Research Fellow
    Protein folding, free energy landscapes, computational biology and biophysics
    Research interests
  • Prof John Ladbury, Dean Faculty of Biological Sciences, Professor of Mechanistic Biology
    Kinase signal transduction
    Research interests
  • Dr Andrew Macdonald, Associate Professor in Virology
    Transformation and immune evasion strategies of DNA tumour viruses
    Research interests
  • Dr Jamel Mankouri, Royal Society University Research Fellow / University Academic Fellow
    Virology, ion channels, cell biology, trafficking
    Research interests
  • Dr Kenneth McDowall, Pro-Dean for Student Education, Senior Lecturer
    Macromolecular Interactions in RNA Processing and Decay
    Research interests
  • Prof Michael McPherson, Professor of Biomolecular Engineering, Director of the BioScreening Technology Group
    Protein engineering and expression; directed evolution; Adhiron artificial binding proteins; copper oxidases; synthetic biology.
    Research interests
  • Dr Stephen Muench, Lecturer in Membrane Biology
    Electron microscopy, X-ray crystallography and protein complexes
    Research interests
  • Dr Mary O'Connell, University Academic Fellow in Biology
    Computational and Molecular Evolutionary Biology: patterns and processes of evolution
    Research interests
  • Dr Alex O'Neill, Associate Professor
    Bacterial resistance to antibiotics; biological characterization of novel antibacterial agents
    Research interests
  • Dr Emanuele Paci, Associate Professor
    Computational Biology; Protein Folding; Molecular Dynamics
    Research interests
  • Prof Michelle Peckham, Professor of Cell Biology
    Bio-imaging, Cell Biology, Muscle structure and differentiation, Molecular Motors
    Research interests
  • Prof Sheena Radford, FMedSci, FRS, Astbury Professor of Biophysics
    Protein folding, Amyloid disease, New biophysical techniques, Molecular chaperones
    Research interests
  • Prof Neil Ranson, Professor
    Cryo-EM; Image Processing; Macromolecular structure
    Research interests
  • Dr Ryan Seipke, Lecturer in Bacteriology
    Microbial natural products: discovery, biosynthesis, regulation and bioengineering
    Research interests
  • Dr Martin Stacey, Lecturer in Immunology
    Research interests
  • Prof Peter Stockley, Professor of Biological Chemistry
    Self-assembling systems: Protein-nucleic acid regulatory complexes; molecular recognition; gene expression; bionanoscience
    Research interests
  • Prof Nicola Stonehouse, Professor of Molecular Virology
    RNA-Protein Interactions in viral systems; RNA aptamers
    Research interests
  • Dr Christopher Thomas, Lecturer
    Plasmid Biology; Protein-DNA and Protein-Protein Interactions
    Research interests
  • Dr Darren Tomlinson, UAF
    siRNA screening – whole and part genome, selection of non-antibody binding reagents, diagnostics and target validation
    Research interests
  • Prof John Trinick, Professor of Animal Cell Biology
    Molecular Motors, Bioelasticity, Giant Proteins, Cryo-electron Microscopy
    Research interests
  • Dr Roman Tuma, Reader in Structural Biology
    Virus, self-assembly, molecular motors, optical tweezers
    Research interests
  • Dr Andrew Tuplin, Lecturer in Molecular and Cellular Biology
    Control of RNA virus genome replication and translation via interactions between RNA structures, host cell proteins and non-coding RNA.
    Research interests
  • Prof David Westhead, Professor of Bioinformatics
    Bioinformatics
    Research interests
  • Prof Adrian Whitehouse, Professor of Molecular Virology
    Viruses and Cancer
    Research interests
  • Dr Stephanie Wright, Senior Lecturer
    Cancer biology, transcription factors, protein degradation, protein-protein interactions, structural biology, X-ray crystallography
    Research interests
  • Dr Anastasia Zhuravleva, Lecturer in Molecular and Cellular Biology
    Research interests