Faculty of Biological Sciences

Elucidate the structures of membrane proteins at atomic resolution and then to apply this structural information to understand the function, cell biology, molecular basis for (patho)-physiology and translational potential of medically important proteins.

The Integrative Membrane Biology (IMB) group brings together experts from a wide range of disciplines to address important questions in the membrane biology field. Research in this area can be subdivided into the themes of Structural Molecular Biology, Channel Biology and Therapeutics, Disease Biology, Neuroscience and Membrane Technology. Our multidisciplinary and highly collaborative environment promotes elucidation of membrane protein systems from the atomic to the cellular and organismal level. This research informs our fundamental understanding of a breadth of membrane biology whilst also informing therapeutic development, the design of novel biosensors, improving crop yields and the development of microbial fuel cells.

Key researchers in this area

  • Channel Biology and Therapeutics
  • Prof Nikita Gamper, Professor of Neuroscience
    Ion channels in sensory neurones and modulation in pain
    Research interests
  • Dr Lin-Hua Jiang, Lecturer
    Molecular mechanisms of ion channels in health and disease
    Research interests
  • Dr Jamie Johnston, UAF in Neuroscience
    Computations in neural circuits
    Research interests
  • Dr Jonathan Lippiat, Lecturer
    Molecular properties and pharmacology of ion channels and transporters
    Research interests
  • Dr Jamel Mankouri, Royal Society University Research Fellow / University Academic Fellow
    Virology, ion channels, cell biology, trafficking
    Research interests
  • Prof Asipu Sivaprasadarao, Professor of Membrane Biology
    Ion channels: structure and cell biology
    Research interests
  • Dr Ian Wood, Senior Lecturer in Neuroscience
    The role of HDACs in neurodegenerative conditions
    Research interests
  • Disease Biology
  • Prof James Deuchars, Professor of Systems Neuroscience
    Spinal cord circuitry controlling autonomic nrevous output, spinal neurogenesis
    Research interests
  • Dr Susan Deuchars, Reader in Neuroscience
    Ion channels, neurotransmitter receptors, transporters and gap junctions influence neuronal and circuit function in the brainstream and spinal cord
    Research interests
  • Dr Dan Donnelly, Senior Lecturer
    G Protein-Coupled Receptor - structure and function
    Research interests
  • Dr James Duce, Lecturer in Neuroscience
    Research interests
  • Prof Nikita Gamper, Professor of Neuroscience
    Ion channels in sensory neurones and modulation in pain
    Research interests
  • Prof Elwyn Isaac, Professor of Comparative Biochemistry
    Comparative biochemistry and functional genomics of neuropeptides and peptidases
    Research interests
  • Dr Lin-Hua Jiang, Lecturer
    Molecular mechanisms of ion channels in health and disease
    Research interests
  • Prof Anne King, Chair of Translational Neuroscience
    How ion channels, gap junction and transporters influence pain processing in the dorsal horn
    Research interests
  • Dr Hugh Pearson, Senior Lecturer
    Voltage gated ion channels and Alzheimer's disease
    Research interests
  • Dr Sreenivasan Ponnambalam, Reader in Human Disease Biology
    Growth factors, Lipid Particles, Signal Transduction, Membrane Trafficking, Vascular Physiology. Control of Blood Vessel Function in Health and Disease.
    Research interests
  • Dr Natalia Riobo-Del Galdo, University Academic Fellow
    Hedgehog signal transduction in cancer and cardiovascular disease
    Research interests
  • Prof Asipu Sivaprasadarao, Professor of Membrane Biology
    Ion channels: structure and cell biology
    Research interests
  • Prof Anthony Turner, Emeritus Professor of Biochemistry
    Membrane metalloproteases in health and disease
    Research interests
  • Dr Ian Wood, Senior Lecturer in Neuroscience
    The role of HDACs in neurodegenerative conditions
    Research interests
  • Membrane Technology
  • Dr Lars Jeuken, Reader in Biophysics
    Membrane Biology, Metalloenzymes, Biophysics, Electron transfer
    Research interests
  • Prof Michael McPherson, Professor of Biomolecular Engineering, Director of the BioScreening Technology Group
    Protein Engineering; Directed Evolution; Copper Oxidases; Protease Inhibitors; Functional Genomics and Proteomics
    Research interests
  • Prof Paul Millner, Professor in Bionanotechnology
    Nano-scale engineering of surfaces for biosensor applications, nanoparticulate supports, bio-affinity systems
    Research interests
  • Prof Sheena Radford, FMedSci, FRS, Astbury Professor of Biophysics
    Protein folding, Amyloid disease, New biophysical techniques, Molecular chaperones
    Research interests
  • Structural Biology
  • Prof Alison Baker, Professor in Plant Cell and Molecular Biology
    Peroxisomes: Biogenesis, Protein Import and Function
    Research interests
  • Dr David Brockwell, Associate Professor
    Single Molecule Mechanical Unfolding of Proteins and their Complexes
    Research interests
  • Dr Dan Donnelly, Senior Lecturer
    G Protein-Coupled Receptor - structure and function
    Research interests
  • Dr James Duce, Lecturer in Neuroscience
    Research interests
  • Prof Adrian Goldman, Chair in Membrane Biology
    Research interests
  • Dr Michael Harrison, Lecturer
    Structure, function and molecular mechanism of the vacuolar H+-ATPase
    Research interests
  • Prof Peter Henderson, Professor of Biochemistry and Molecular Biology
    Membrane Proteins, Sugar Transport, Antibiotic Resistance
    Research interests
  • Dr Eric Hewitt, Senior Lecturer
    Cellular Interactions with Amyloid and Molecular Immunology
    Research interests
  • Dr Lin-Hua Jiang, Lecturer
    Molecular mechanisms of ion channels in health and disease
    Research interests
  • Prof Michael McPherson, Professor of Biomolecular Engineering, Director of the BioScreening Technology Group
    Protein Engineering; Directed Evolution; Copper Oxidases; Protease Inhibitors; Functional Genomics and Proteomics
    Research interests
  • Dr Stephen Muench, Lecturer in Membrane Biology
    Electron microscopy, X-ray crystallography and protein complexes
    Research interests
  • Dr Sreenivasan Ponnambalam, Reader in Human Disease Biology
    Growth factors, Lipid Particles, Signal Transduction, Membrane Trafficking, Vascular Physiology. Control of Blood Vessel Function in Health and Disease.
    Research interests
  • Prof Sheena Radford, FMedSci, FRS, Astbury Professor of Biophysics
    Protein folding, Amyloid disease, New biophysical techniques, Molecular chaperones
    Research interests
  • Prof Asipu Sivaprasadarao, Professor of Membrane Biology
    Ion channels: structure and cell biology
    Research interests