Faculty of Biological Sciences

Motion of myosin V molecules on actin

When using these animations in any way, please acknowledge:
Matthew L. Walker, Stan A. Burgess, James R. Sellers, Fei Wang, John A. Hammer III, John Trinick & Peter J. Knight. Two-headed Binding of a Processive Myosin to F-actin. Nature, 405, 804-807 (2000).

These animations were created from a series of images of different molecules.
Computer-based image processing aligned the images so that the actin filament polarity is the same in each and oriented such that walking is towards the right.
The actin is shown moving to the left, in order that the myosin stays central. In the cell the actin filaments form a scaffold and so, of course, it is the myosin which moves.