The studentships are designed to invest in the training of the next generation of scientists for the wider bioeconomy and research base, providing access to facilities and expertise unavailable in an academic setting alone.
Working collaboratively, MedImmune and the universities will co-locate the four-year-long studentships to advance discovery and development in Industrial Biotechnology and Bioenergy.
Under the programme, students will benefit from:
In addition, the Collaborative Training Partnership (CTP) will provide exposure to upstream and downstream bioprocessing, cell sciences, formulation and analytical science, drug delivery, in silico modelling and automation.
The CTP will build on already established research partnerships at MedImmune to support product and technology development. The Centre for Process Innovation in Darlington will join the consortium to add expertise in the development of next generation products and processes and advise on future bioprocessing trends and capabilities.
The first round of studentships will commence in October 2017, and additional intakes will follow in October 2018 and 2019. Further information and application details for the first studentship will be made available on 1st December on FindAPhD and the University of Leeds’ website.
The three successful PhD students at Leeds will work in biopharmaceutical development, using state-of-the-art biophysical equipment within the Astbury Centre for Structural Molecular Biology using mass spectroscopy and single molecule techniques.
Working with investigators in the biological sciences and engineering, the students will study how proteins respond to flow pressures and how this causes aggregation. They will aim to develop ways to improve methods for the production of proteins as drugs of impact across the biopharmaceutical industry.
Professor Sheena Radford, FMedSci, FRS, Director of the Astbury Centre, welcomed the BBSRC funding and said Leeds was pleased to develop further its links with MedImmune, and new relationships with researchers in Cambridge, Manchester and Sheffield.
She said: “Many new drugs coming on to the market are protein-based, so it’s vital scientists and engineers collaborate across universities to understand how proteins aggregate and how and why flow processes in the production pipeline cause failure to produce large quantities of protein drugs needed for clinical use.
“By doing so we will evolve better proteins, improve the drug production process and ultimately avoid the 11th hour fails which are so frustrating in this industry”.
“This investment by the BBSRC is a significant commitment and is well timed given the University’s own £17m investment in the leading-edge technology required to carry it out.”
Paul Varley, Vice President of Science and Collaborations in Biopharmaceutical Development at MedImmune said: “Collaborating to create new avenues for the exchange of innovative ideas is a critical part of drug discovery and development.
“We’re honoured that the BBSRC has afforded us this opportunity to offer a world-class training environment for the next generation of biopharmaceutical scientists, extend core capabilities in bioprocessing and analysis, and embrace new thinking, allowing science to thrive and ultimately deliver life-changing medicines to patients."
Helen Miller, Innovate UK (Apr 2018), £999,960
Elisabetta Groppelli, David Rowlands & Stanley Lemon (University of North Carolina), Medical Research Foundation Fellowship (Apr 2018), £293,494
Nikesh Patel, Medical Research Foundation fellowship (Apr 2018), £290,976
Jessica Kwok & Ralf Richter, Leverhulme Trust (Apr 2018), £298,273
Julie Aspden, Royal Society (Apr 2018), £20,000
Liz Duncan, Royal Society (Mar 2018), £14,602
Alex O'Neill & Ryan Seipke, BBSRC (Feb 2018), £45,489
Jim Deuchars, Royal Society (Feb 2018), £16,300
Stefan Kepinski & Netta Cohen, Leverhulme Trust (Feb 2018), £320,387
Lisa Collins, BBSRC (Feb 2018), £49,950
Lars Jeuken, BBSRC (Feb 2018), £30,000
Nikita Gamper, BBSRC (Feb 2018), £30,000
Alison Baker, BBSRC (Feb 2018), £30,000
Scott Bowen, Leducq Foundation Grant (Feb 2018), £28,470
Jessica Kwok and Ronaldo Ichiyama, International Spinal Research Trust (Feb 2018), £94,450
Alex O'Neill, Oxford Drug Design (Jan 2018), £86,098
Dave Lewis and Colleagues in South Africa, HEFCE Global Challenge Research (Jan 2018), £48,000
Sarah Calaghan, Ed White, John Colyer, Isuru Jayasinghe, BHF (Jan 2018), £128,308
Christine Foyer and Alison Baker, HEFCE GCRF Grant (Jan 2018), £71,158
Alison Baker, Yun Yung Gong and Lindsay Stringer and ICRISAT India, HEFCE GCRF Grant (Jan 2018), £27,000
Graham Askew, Simon Walker, BBSRC (Jan 2018), £699,781
Jennifer Tomlinson, Royal Society (Jan 2018), £512,801
Alison Dunn, NERC (Dec 2017), £18,000
Jennifer Tomlinson, Royal Society-Research Fellows Enhancement Award (Dec 2017), £94,681
Helen Miller, AB AGri Grant (Dec 2017), £73,600
Simon Walker, Royal Society Enhancement Award (Dec 2017), £10,000
Carrie Ferguson, Bryan Taylor, Harry Rossiter, The Physiological Society (Dec 2017), £7,392
Ralf Richter, Royal Society (Dec 2017), £6,000
Christine Foyer, British Council Newton Fund (Dec 2017), £49,840
Adrian Whitehouse and colleagues in School of Chemistry and University of Liverpool, MRC (Nov 2017), £622,319
Michelle Peckham, Neil Ransom, MRC (Nov 2017), £495,159
Dave Lewis, British Council India (Nov 2017), £22,540
Elton Zeqiraj, Royal Society (Nov 2017), £15,000
Hannah Dugdale, Royal Society (Nov 2017), £15,000
Shaunna Burke, Cancer Research UK Innovation Grant (Nov 2017), £20,000
Alex O'Neill and colleagues in Chemistry, BBSRC (Nov 2017), £431,865
Jessica Kwok, Wings for Life (Nov 2017), £87,365
Tom Bennett, BBSRC (Oct 2017), £523,679
Neil Ranson, Darren Tomlinson, BBSRC (Oct 2017), £494,318
Nikita Gamper, BBSRC (Oct 2017), £490,426
Amanda Bretman and colleagues from UEA, NERC (Oct 2017), £430,886
Juan Fontana, Rosetrees Trust consumables grant (Oct 2017), £22,500
Helen Miller, DSM Nutritional Products AG (Sep 2017), £69,988
Neil Ranson, Juan Fontana, Mark Harris, Michelle Peckham, Ralf Richter, Peter Stockley, Patricija Van Oosten-Hawle and colleagues in Engineering, FMH and MAPS, Wellcome Trust Equipment Call (Sep 2017), £418,000
Jamie Johnston, Physiological Society (Sep 2017), £10,000
Frank Sobott, Adrian Goldman, Mark Harris, Andrew Macdonald, Stephen Muench, Sheena Radford and colleagues in FMH and MAPS, Wellcome Trust Equipment Call (Aug 2017), £415,000
Ralf Richter, David Brockwell, Eric Hewitt, Jessica Kwok, Emanuele Paci and MAPS/FMH, BBSRC (Jun 2017), £600,000
Eric Blair, Adrian Whitehouse, Nicola Stonehouse, Alison Baker, Richard Bayliss, Joan Boyes, Ryan Seipke, Sally Boxall and MAPS/FMH, BBSRC (Jun 2017), £376,000
Stefan Kepinski, Yoselin Benitez-Alfonso, Tom Bennett, Michelle Peckham, BBSRC (Jun 2017), £331,000
Roman Tuma, Lars Jeuken, Paul Millner, Sheena Radford, Peter Stockley and MAPS/FMH, BBSRC (Jun 2017), £222,000
Vas Ponnambalam, Darren Tomlinson, Stephen Wheatcroft, BHF (May 2017), £107,878