The studentships are designed to invest in the training of the next generation of scientists for the wider bioeconomy and research base, providing access to facilities and expertise unavailable in an academic setting alone.
Working collaboratively, MedImmune and the universities will co-locate the four-year-long studentships to advance discovery and development in Industrial Biotechnology and Bioenergy.
Under the programme, students will benefit from:
In addition, the Collaborative Training Partnership (CTP) will provide exposure to upstream and downstream bioprocessing, cell sciences, formulation and analytical science, drug delivery, in silico modelling and automation.
The CTP will build on already established research partnerships at MedImmune to support product and technology development. The Centre for Process Innovation in Darlington will join the consortium to add expertise in the development of next generation products and processes and advise on future bioprocessing trends and capabilities.
The first round of studentships will commence in October 2017, and additional intakes will follow in October 2018 and 2019. Further information and application details for the first studentship will be made available on 1st December on FindAPhD and the University of Leeds’ website.
The three successful PhD students at Leeds will work in biopharmaceutical development, using state-of-the-art biophysical equipment within the Astbury Centre for Structural Molecular Biology using mass spectroscopy and single molecule techniques.
Working with investigators in the biological sciences and engineering, the students will study how proteins respond to flow pressures and how this causes aggregation. They will aim to develop ways to improve methods for the production of proteins as drugs of impact across the biopharmaceutical industry.
Professor Sheena Radford, FMedSci, FRS, Director of the Astbury Centre, welcomed the BBSRC funding and said Leeds was pleased to develop further its links with MedImmune, and new relationships with researchers in Cambridge, Manchester and Sheffield.
She said: “Many new drugs coming on to the market are protein-based, so it’s vital scientists and engineers collaborate across universities to understand how proteins aggregate and how and why flow processes in the production pipeline cause failure to produce large quantities of protein drugs needed for clinical use.
“By doing so we will evolve better proteins, improve the drug production process and ultimately avoid the 11th hour fails which are so frustrating in this industry”.
“This investment by the BBSRC is a significant commitment and is well timed given the University’s own £17m investment in the leading-edge technology required to carry it out.”
Paul Varley, Vice President of Science and Collaborations in Biopharmaceutical Development at MedImmune said: “Collaborating to create new avenues for the exchange of innovative ideas is a critical part of drug discovery and development.
“We’re honoured that the BBSRC has afforded us this opportunity to offer a world-class training environment for the next generation of biopharmaceutical scientists, extend core capabilities in bioprocessing and analysis, and embrace new thinking, allowing science to thrive and ultimately deliver life-changing medicines to patients."
Graham Askew, Simon Walker, BBSRC (Jan 2018), £699,781
Jennifer Tomlinson, Royal Society (Jan 2018), £512,801
Alex O'Neill and colleagues in Chemistry, BBSRC (Nov 2017), £431,865
Tom Bennett, BBSRC (Oct 2017), £523,679
Neil Ranson, Darren Tomlinson, BBSRC (Oct 2017), £494,318
Nikita Gamper, BBSRC (Oct 2017), £490,426
Amanda Bretman and colleagues from UEA, NERC (Oct 2017), £430,886
Juan Fontana, Rosetrees Trust consumables grant (Oct 2017), £22,500
Helen Miller, DSM Nutritional Products AG (Sep 2017), £69,988
Neil Ranson, Juan Fontana, Mark Harris, Michelle Peckham, Ralf Richter, Peter Stockley, Patricija Van Oosten-Hawle and colleagues in Engineering, FMH and MAPS, Wellcome Trust Equipment Call (Sep 2017), £418,000
Jamie Johnston, Physiological Society (Sep 2017), £10,000
Frank Sobott, Adrian Goldman, Mark Harris, Andrew Macdonald, Stephen Muench, Sheena Radford and colleagues in FMH and MAPS, Wellcome Trust Equipment Call (Aug 2017), £415,000
Ralf Richter, David Brockwell, Eric Hewitt, Jessica Kwok, Emanuele Paci and MAPS/FMH, BBSRC (Jun 2017), £600,000
Eric Blair, Adrian Whitehouse, Nicola Stonehouse, Alison Baker, Richard Bayliss, Joan Boyes, Ryan Seipke, Sally Boxall and MAPS/FMH, BBSRC (Jun 2017), £376,000
Stefan Kepinski, Yoselin Benitez-Alfonso, Tom Bennett, Michelle Peckham, BBSRC (Jun 2017), £331,000
Roman Tuma, Lars Jeuken, Paul Millner, Sheena Radford, Peter Stockley and MAPS/FMH, BBSRC (Jun 2017), £222,000
Vas Ponnambalam, Darren Tomlinson, Stephen Wheatcroft, BHF (May 2017), £107,878
Graham Askew in collaboration with Bangor University, BBSRC (Mar 2017), £477,383
Stephen Muench, BBSRC (Mar 2017), £132,945
Nic Stonehouse, MRC (Mar 2017), £906,341
Bill Kunin, Steve Sait, BBSRC (Mar 2017), £602,831
Adrian Goldman, EU (Mar 2017), £546,576
Sheena Radford, Wellcome Trust (Mar 2017), £1,836,482
Jamie Johnston, Royal Society (Mar 2017), £15,000
Beatrice Filippi, Royal Society (Mar 2017), £15,000
Tom Bennett, Royal Society (Mar 2017), £15,000
Ryan Seipke, BBSRC (Feb 2017), £52,116
Mary O'Connell, BBSRC (Feb 2017), £46,986
Hannah Dugdale, NERC (Feb 2017), £504,138
Anastasia Zhuravleva, EPSRC (Jan 2017), £100,792
Richard Bayliss, Cancer Research UK (Jan 2017), £1,600,000
John Barr, EU (Jan 2017), £339,000
Mark Harris, Royal Society (Jan 2017), £250,000
Alison Dunn, NERC (Jan 2017), £105,000
Alex Breeze, Pancreatic Cancer Research Fund (Jan 2017), £180,000
Alison Dunn, NERC (Dec 2016), £18,000
Lisa Collins, BBSRC (Dec 2016), £1,681,835
Brendan Davies, Leverhulme Trust (Dec 2016), £247,555
Alan Benson, Mark Drinkhill, Ed White, British Heart Foundaion (Dec 2016), £217,223
Adrian Goldman, Royal Society (Dec 2016), £82,999
Lisa Roberts, Alex Breeze, Brendan Davies, Timothy Devinney, Oliver Harlen, Joseph Holden, Anthea Hucklesby, Pamela Jones, Philip Mellor, RCUK (Nov 2016), £484,172
Lisa Roberts, Alex Breeze, Brendan Davies, Timothy Devinney, Oliver Harlen, Joseph Holden, Anthea Hucklesby, Pamela Jones, Philip Mellor, Wellcome Trust (Nov 2016), £119,343
Katie Field, Rank Prize Funds (Nov 2016), £20,000
Jessica Kwok, Royal Society (Nov 2016), £14,948
John Ladbury, Cancer Research UK (Oct 2016), £4,250
Miriam Wittmann, Martin Stacey, Edward Vital, Lupus UK
(Oct 2016), £34,010
Valerie Speirs, NC3Rs
(Oct 2016), £90,000
Nicola Stonehouse, Morgan Herod, David Rowlands, BBSRC
(Sep 2016), £436,424
Joseph Cockburn, Wellcome Trust
(Sep 2016), £100,000
John Barr, Public Health England
(Sep 2016), £94,471
Helen Miller, DSM Nutritional Products A/S
(Sep 2016), £54,680
Steven Clapcote, Vitaflo International Ltd
(Sep 2016), £39,285
Juan Fontana Jordan De Urries
, Royal Society
(Sep 2016), £21,793
Jing Li, Sarah Calaghan, Mark Drinkhill, British Heart Foundation
(Sep 2016), £117,585