The new resource, funded by the charity Leukaemia & Lymphoma Research, will store cancer cell samples and anonymous medical records of patients with non-Hodgkin lymphoma blood cancers in the Yorkshire region, allowing doctors access to richly detailed information about similar previous patients when treating new cases.
It is a world-leading example of the use of "big data" to improve outcomes for patients and a breakthrough for the treatment of non-Hodgkin lymphoma, which relies on tailoring interventions closely to particular patients.
David Westhead, Professor of Bioinformatics at the University of Leeds, said: "It is increasingly clear that cancer in general and lymphoma in particular is a highly variable disease. Individuals previously diagnosed in the same broad categories may have diseases that are quite different when you look at the fundamental biology of their cancers. This database enables us to take a step towards more individualised treatment."
Non-Hodgkin lymphoma is diagnosed in about 10,000 people a year in the UK, making it the sixth most common form of cancer, and normally appears as a solid tumour in glands called lymph nodes.
One of the key challenges in treating it is its diversity. Non-Hodgkin lymphoma can be divided into up to 40 different diseases, each of which is treated differently. Even within these subcategories, there can be very significant differences between individual patients, with different genetic faults in an individual's lymphoma cells dictating whether certain drugs will be effective or not.
The database and data mining techniques developed by researchers at the University of Leeds' Faculty of Biological Sciences are expected revolutionise treatment.
Doctors will be able to cast aside traditional disease categories, which were defined when scientists couldn't look at cells at a molecular level, and search the database for previous patients whose lymphoma has similarities at a biological level to newly diagnosed patients.
Knowing which of the various possible treatments were most successful in similar patients in the past will help guide treatment for current patients.
Professor Westhead said: "It is very important that what we learn from treating lymphoma patients can be used in the future. We believe this new approach will improve on the current practice of assigning patients to rigid disease categories that in reality are overlapping."
Dr Matt Kaiser, Head of Research at Leukaemia & Lymphoma Research, which is providing £250,000 to support the project, said: "We already know that lymphomas are highly variable in their prognosis and response to standard treatments. By intelligently linking the patient's biology with clinical outcome, future patients will benefit from smarter diagnosis, more accurate prognosis and a more tailored treatment course. This is a pioneering approach that may have ramifications for how we view and treat all cancers."
Helen Miller, Innovate UK (Apr 2018), £999,960
Elisabetta Groppelli, David Rowlands & Stanley Lemon (University of North Carolina), Medical Research Foundation Fellowship (Apr 2018), £293,494
Nikesh Patel, Medical Research Foundation fellowship (Apr 2018), £290,976
Jessica Kwok & Ralf Richter, Leverhulme Trust (Apr 2018), £298,273
Julie Aspden, Royal Society (Apr 2018), £20,000
Liz Duncan, Royal Society (Mar 2018), £14,602
Alex O'Neill & Ryan Seipke, BBSRC (Feb 2018), £45,489
Jim Deuchars, Royal Society (Feb 2018), £16,300
Stefan Kepinski & Netta Cohen, Leverhulme Trust (Feb 2018), £320,387
Lisa Collins, BBSRC (Feb 2018), £49,950
Lars Jeuken, BBSRC (Feb 2018), £30,000
Nikita Gamper, BBSRC (Feb 2018), £30,000
Alison Baker, BBSRC (Feb 2018), £30,000
Scott Bowen, Leducq Foundation Grant (Feb 2018), £28,470
Jessica Kwok and Ronaldo Ichiyama, International Spinal Research Trust (Feb 2018), £94,450
Alex O'Neill, Oxford Drug Design (Jan 2018), £86,098
Dave Lewis and Colleagues in South Africa, HEFCE Global Challenge Research (Jan 2018), £48,000
Sarah Calaghan, Ed White, John Colyer, Isuru Jayasinghe, BHF (Jan 2018), £128,308
Christine Foyer and Alison Baker, HEFCE GCRF Grant (Jan 2018), £71,158
Alison Baker, Yun Yung Gong and Lindsay Stringer and ICRISAT India, HEFCE GCRF Grant (Jan 2018), £27,000
Graham Askew, Simon Walker, BBSRC (Jan 2018), £699,781
Jennifer Tomlinson, Royal Society (Jan 2018), £512,801
Alison Dunn, NERC (Dec 2017), £18,000
Jennifer Tomlinson, Royal Society-Research Fellows Enhancement Award (Dec 2017), £94,681
Helen Miller, AB AGri Grant (Dec 2017), £73,600
Simon Walker, Royal Society Enhancement Award (Dec 2017), £10,000
Carrie Ferguson, Bryan Taylor, Harry Rossiter, The Physiological Society (Dec 2017), £7,392
Ralf Richter, Royal Society (Dec 2017), £6,000
Christine Foyer, British Council Newton Fund (Dec 2017), £49,840
Adrian Whitehouse and colleagues in School of Chemistry and University of Liverpool, MRC (Nov 2017), £622,319
Michelle Peckham, Neil Ransom, MRC (Nov 2017), £495,159
Dave Lewis, British Council India (Nov 2017), £22,540
Elton Zeqiraj, Royal Society (Nov 2017), £15,000
Hannah Dugdale, Royal Society (Nov 2017), £15,000
Shaunna Burke, Cancer Research UK Innovation Grant (Nov 2017), £20,000
Alex O'Neill and colleagues in Chemistry, BBSRC (Nov 2017), £431,865
Jessica Kwok, Wings for Life (Nov 2017), £87,365
Tom Bennett, BBSRC (Oct 2017), £523,679
Neil Ranson, Darren Tomlinson, BBSRC (Oct 2017), £494,318
Nikita Gamper, BBSRC (Oct 2017), £490,426
Amanda Bretman and colleagues from UEA, NERC (Oct 2017), £430,886
Juan Fontana, Rosetrees Trust consumables grant (Oct 2017), £22,500
Helen Miller, DSM Nutritional Products AG (Sep 2017), £69,988
Neil Ranson, Juan Fontana, Mark Harris, Michelle Peckham, Ralf Richter, Peter Stockley, Patricija Van Oosten-Hawle and colleagues in Engineering, FMH and MAPS, Wellcome Trust Equipment Call (Sep 2017), £418,000
Jamie Johnston, Physiological Society (Sep 2017), £10,000
Frank Sobott, Adrian Goldman, Mark Harris, Andrew Macdonald, Stephen Muench, Sheena Radford and colleagues in FMH and MAPS, Wellcome Trust Equipment Call (Aug 2017), £415,000
Ralf Richter, David Brockwell, Eric Hewitt, Jessica Kwok, Emanuele Paci and MAPS/FMH, BBSRC (Jun 2017), £600,000
Eric Blair, Adrian Whitehouse, Nicola Stonehouse, Alison Baker, Richard Bayliss, Joan Boyes, Ryan Seipke, Sally Boxall and MAPS/FMH, BBSRC (Jun 2017), £376,000
Stefan Kepinski, Yoselin Benitez-Alfonso, Tom Bennett, Michelle Peckham, BBSRC (Jun 2017), £331,000
Roman Tuma, Lars Jeuken, Paul Millner, Sheena Radford, Peter Stockley and MAPS/FMH, BBSRC (Jun 2017), £222,000
Vas Ponnambalam, Darren Tomlinson, Stephen Wheatcroft, BHF (May 2017), £107,878