Faculty of Biological Sciences

Research Bulletin

Following genetic footprints out of Africa

26th January 2012

A new study, using genetic analysis to look for clues about human migration over 60,000 years ago, suggests that the first modern humans settled in Arabia on their way from the Horn of Africa to the rest of the world.

Led by the University of Leeds and the University of Porto in Portugal, the study is published today in American Journal of Human Genetics and provides intriguing insight into the earliest stages of modern human migration, say the researchers.

"A major unanswered question regarding the dispersal of modern humans around the world concerns the geographical site of the first steps out of Africa," explains Dr Luísa Pereira from the Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP). "One popular model predicts that the early stages of the dispersal took place across the Red Sea to southern Arabia, but direct genetic evidence has been thin on the ground."

The international research team, which included colleagues from across Europe, Arabia and North Africa, analysed three of the earliest non-African maternal lineages. These early branches are associated with the time period when modern humans first successfully moved out of Africa.

Using mitochondrial DNA analysis, which traces the female line of descent and is useful for comparing relatedness between different populations, the researchers compared complete genomes from Arabia and the Near East with a database of hundreds more samples from Europe. They found evidence for an ancient ancestry within Arabia.

Professor Martin Richards of the University of Leeds' Faculty of Biological Sciences, said: "The timing and pattern of the migration of early modern humans has been a source of much debate and research. Our new results suggest that Arabia, rather than North Africa or the Near East, was the first staging-post in the spread of modern humans around the world."

The research was funded by the Portuguese Foundation for Science and Technology, the Leverhulme Trust, and the DeLaszlo Foundation.


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Bill Kunin, EU (Jan 2015), £157,490

John Colyer, Leeds Teaching Hospitals Charitable Fund (Jan 2015), £40,000

Chris Hassall, Royal Society (Dec 2014), £14,500

Ryan Seipke, Royal Society (Nov 2014), £13,700

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Alison Ashcroft, Peter Stckley, Sheena Radford, Nic Stonehouse, David Brockwell, Darren Tomlinson, BBSRC (Oct 2014), £340,937

Les Firbank, Joe Holden, BBSRC (Oct 2014), £210,302

Darren Tomlinson and colleagues in Chemistry and Pathology, anatomy and Tumour Biology, Dr Hadwen Trusy (Oct 2014), £194,475

Paul Knox, EU (Oct 2014), £167,229

Martin Stacey and colleagues in Medicine & Health, Pfizer (Oct 2014), £90,453

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Dave Westhead and colleagues in Experimental Haemotology, Leukaemia & Lymphoma Research (Sep 2014), £281,424

Emmanuel Paci and colleagues in Chemistry, BBSRC (Sep 2014), £636,759

Andrew Peel, BBSRC (Sep 2014), £371,598

Lars Jeuken, Stephen Evans, BBSRC (Sep 2014), £333,684

Lars Jeuken, BBSRC (Sep 2014), £313,463

Michelle Peckham, Mark Harris, Rao Sivaprasadarao, Eileen Ingham, Nic Stonehouse, Nikita Gamper, Wellcome Trust (Sep 2014), £192,763

Neil Ranson, BBSRC (Aug 2014), £355,253

Stuart Egginton, BHF (Aug 2014), £271,094

Darren Tomlinson, Mike McPherson, Technology Strategy Board (Aug 2014), £98,665

Peter Henderson, Leverhulme Trust (Aug 2014), £15,222

Mike McPherson (and colleagues in the School of Chemistry), EPSRC (Jul 2014), £819,880

Peter Stockley, Neil Ranson, BBSRC (Jul 2014), £455,787

Sheena Radford, Univesity of Michigan (Jul 2014), £138,452

Ryan Seipke, British Society Antimicrobial Chemistry (Jun 2014), £11,960

John Trinick, BHF (Jun 2014), £222,614

Chris West, Leverhulme Trust (Jun 2014), £181,241

Jon Lippiat, Darren Tomlinson, BBSRC (May 2014), £125,174

Christine Foyer, Royal Society (May 2014), £24,000

David Brockwell, Sheena Radford, Medimmune Ltd (Apr 2014), £337,661

Peter Stockley, Wellcome Trust (Apr 2014), £251,019

Mike McPherson, Wellcome Trust (Apr 2014), £146,596

Andrew Macdonald, Kidney Research Fund UK (Apr 2014), £127,237

Elwyn Isaac, DEFRA (Apr 2014), £126,512

Mike McPherson (and colleagues in School of Design), Technology Strategy Board (Apr 2014), £114,350

Paul Millner, Peter Stockley, Darren Tomlinson, YCR (Apr 2014), £95,874

Carrie Ferguson, Karen Birch, Shaunna Burke, Heart Research UK (Apr 2014), £60,140

Tim Benton, Technology Strategy Board (Apr 2014), £24,969

Bill Kunin, Technology Strategy Board (Apr 2014), £21,244

Dave Westhead, MRC (Apr 2014), £18,304

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