Prof. Shervanthi Homer-Vanniasinkam


Consultant vascular surgeon & Professor of Translational Vascular Medicine
Leeds Vascular Institute & Leeds Institute of Genetics, Health & Therapeutics (LIGHT)

Background: IBSc (1976), Bangalore University, MBBS (1981), Mysore University, India. Fellow of the Royal College of Surgeons of Edinburgh (FRCSE) in 1989, Fellow of the Royal College of Surgeons (FRCS) in 1998. Currently a consultant vascular surgeon at the Unit of Vascular Surgery (Leeds General Infirmary; 1995-present) and Clinical Sub-Dean for Leeds University Medical School (2003-present). Also Professor of Translational Vascular Medicine (1998-present) and Director of the Institute of Atherothrombosis (2006-present) at Bradford University. Visiting research professor at Louisiana State University (USA) in 2002.

Office: Leeds Vascular Institute, Leeds General Infirmary
Phone: +44(0) 113 392 2628

Centre membership:

Lab: Leader of the Homer-Vanniasinkam lab

You can read more about Prof. Homer-Vanniasinkam's interests here:

Research Interests

Molecular, cellular and higher order models to study human disease and vascular dysfunction


Current Projects

Our work is funded by the Heart Research UK, European Union, British Heart Foundation and Pfizer Global Inc.

Student & medical research project information

Principal interests:


Medical undergraduate, postgraduate (PhD) and MD research areas:

Selected publications

Devanesan AJ, Laughlan KA, Girn HR, Homer-Vanniasinkam S. Endothelial Progenitor Cells as a Therapeutic Option in Peripheral Arterial Disease. Eur JVasc Endovasc Surg. 2009 Jun 26 [Epub ahead of print].

Dumville JC, Worthy G, Bland JM, Cullum N, Dowson C, Iglesias C, Mitchell JL, Nelson EA, Soares MO, Torgerson DJ; VenUS II team. Larval therapy for leg ulcers (VenUS II): randomised controlled trial. BMJ. 2009 338: b773 doi:10.1136/bmj.b773.

Girn HR, McPherson S, Nicholson T, Mavor AI, Homer-Vanniasinkam S, Gough MJ.Short series of emergency stent-graft repair of symptomatic penetrating thoracic aortic ulcers (PTAU). Vasc Med. 2009 14: 123-128.

Dickinson KJ, Cockbain AJ, MacDonald W, Shah M, Homer-Vanniasinkam S. Thephysiological effects of short-term smoking cessation in claudicants. Angiology. 2009 60: 159-163.

Derham C, Yow H, Ingram J, Fisher J, Ingham E, Korrosis SA, Homer-Vanniasinkam S. Tissue engineering small-diameter vascular grafts: preparation of a biocompatible porcine ureteric scaffold. Tissue Eng Part A. 2008 14: 1871-1882.

Roberts W, Riba R, Homer-Vanniasinkam S, Farndale RW, Naseem KM. Nitric oxide specifically inhibits integrin-mediated platelet adhesion and spreading oncollagen. J Thromb Haemost. 2008 6: 2175-2185.

Dickinson KJ, Troxler M, Homer-Vanniasinkam S. The surgical application of point-of-care haemostasis and platelet function testing. Br J Surg. 2008 95:1317-1330.

Chaparala RP, Orsi NM, Lindsey NJ, Girn RS, Homer-Vanniasinkam S. Inflammatory profiling of peripheral arterial disease. Ann Vasc Surg. 2009 23: 172-178.

Eccles KA, Sowden H, Porter KE, Parkin SM, Homer-Vanniasinkam S, Graham AM. Simvastatin alters human endothelial cell adhesion molecule expression andinhibits leukocyte adhesion under flow. Atherosclerosis. 2008 200: 69-79.

Albazaz R, Wong YT, Homer-Vanniasinkam S. Complex regional pain syndrome: a review. Ann Vasc Surg. 2008 22: 297-306.

Girn HR, Orsi NM, Homer-Vanniasinkam S. An overview of cytokine interactions in atherosclerosis and implications for peripheral arterial disease. Vasc Med. 2007 12: 299-309.

Coughlin PA, Gulati V, Mavor AI, Gough MJ, Homer-Vanniasinkam S. Risk factor awareness in patients with peripheral arterial disease. J Cardiovasc Surg (Torino). 2007 48: 735-740.

Girn HR, Ahilathirunayagam S, Mavor AI, Homer-Vanniasinkam S. Reperfusionsyndrome: cellular mechanisms of microvascular dysfunction and potential therapeutic strategies. Vasc Endovascular Surg. 2007 41: 277-293.

Homer-Vanniasinkam S. Surgical site and vascular infections: treatment and prophylaxis. Int J Infect Dis. 2007 11 Suppl 1: S17-22.

Troxler M, Dickinson K, Homer-Vanniasinkam S. Platelet function and antiplatelet therapy. Br J Surg. 2007 94: 674-682.

Homer-Vanniasinkam S. Treatment of intra-abdominal and skin and soft tissue infections: The role of the glycylcyclines. Int J Surg. 2006 4: 45-52.

Derham C, Davies JF, Shahbazi R, Homer-Vanniasinkam S. Iatrogenic limb ischemia caused by angiography closure devices. Vasc Endovascular Surg 2006 40: 492-4.

Vohra RS, Murphy JE, Walker JH, Homer-Vanniasinkam S, Ponnambalam S. Functional refolding of a recombinant C-type lectin-like domain containing intramolecular disulfide bonds. Protein Expression & Purification 2007 52: 415-421.

Vohra RS, Murphy JE, Walker JH, Ponnambalam S, Homer-Vanniasinkam S.Atherosclerosis and the LOX-1 scavenger receptor. Trends in Cardiovascular Medicine 2006 16: 60-64.