Research Institute of Membrane and Systems Biology

Recent publication highlights

Simone Weyand, Tatsuro Shimamura, Shunsuke Yajima, Shun'ichi Suzuki, Osman Mirza, Kuakarun Krusong, Elisabeth P. Carpenter, Nicholas G. Rutherford, Jonathan M. Hadden, John O'Reilly, Pikyee Ma, Massoud Saidijam, Simon G. Patching, Ryan J. Hope, Halina T. Norbertczak, Peter C. J. Roach, So Iwata, Peter J. F. Henderson, Alexander D. Cameron., Structure and Molecular Mechanism of a Nucleobase Cation Symport-1 Family Transporter Science. 322, 709 (2008); DOI: 10.1126/science.1164440

Xu SZ, Sukumar P, Zeng F, Li J, Jairaman A, English A, Naylor J, Ciurtin C, Majeed Y, Milligan CJ, Bahnasi YM, AL-Shawaf E, Porter KE, Jiang LH, Emery P, Sivaprasadarao A, Beech DJ (2008). TRPC channel activation by extracellular thioredoxin.  Nature 451, 69-72.

Edwards IJ, Dallas ML, Poole SL, Milligan CJ, Yanagawa Y, Szabó G, Erdélyi F, Deuchars SA, Deuchars J (2007).  The neurochemically diverse intermedius nucleus of the medulla as a source of excitatory and inhibitory synaptic input to the nucleus tractus solitarii. Journal of Neuroscience 27, 8324-8333.

Jones SA, Boyett MR, Lancaster MK (2007).  Declining into failure: the age-dependent loss of the L-type calcium channel within the sinoatrial node. Circulation 115, 1183-1190.

Gamper N, Zaika O, Li Y, Martin P, Hernandez CC, Perez MR, Wang AY, Jaffe DB, Shapiro MS. (2006). Oxidative modification of M-type K channels as a mechanism of cytoprotective neuronal silencing.  EMBO Journal 25, 4996-5004.

Mankouri J, Taneja TK, Smith AJ, Ponnambalam S, Sivaprasadarao A. (2006).  Kir6.2 mutations causing neonatal diabetes prevent endocytosis of ATP-sensitive potassium channels.  EMBO Journal 25, 4142-51.

Smith SA, Mutch NJ, Baskar D, Rohloff P, Docampo R, Morrissey JH. (2006).  Polyphosphate modulates blood coagulation and fibrinolysis. Proc Natl Acad Sci U S A 103, 903-8.

Barnes K, Dobrzynski H, Foppolo S, Beal PR, Ismat F, Scullion ER, Sun L, Tellez J, Ritzel MW, Claycomb WC, Cass CE, Young JD, Billeter-Clark R, Boyett MR, Baldwin SA. (2006). Distribution and functional characterization of equilibrative nucleoside transporter-4, a novel cardiac adenosine transporter activated at acidic pH.  Circulation Research 99, 510-9.

Xu SZ, Zeng F, Lei M, Li J, Gao B, Xiong C, Sivaprasadarao A, Beech DJ (2005) Generation of functional ion-channel tools by E3 targeting. Nature Biotechnology 23, 1289-1293.

Cheong A, Bingham AJ, Li J, Kumar B, Sukumar P, Munsch C, Buckley NJ, Neylon CB, Porter KE, Beech DJ, Wood IC (2005) Downregulated REST Transcription Factor Is a Switch Enabling Critical Potassium Channel Expression and Cell Proliferation. Molecular Cell 20, 45-52.

Morton M,  Abohamed A, Sivaprasadarao A, Hunter M (2005)  pH-sensing in the two-pore domain K channel, TASK-2.  Proc. Natl. Acad. Sci. USA 102, 16102-6.

Salter MG, Fern R. (2005).  NMDA receptors are expressed in developing oligodendrocyte processes and mediate injury.  Nature 438, 1167-71.