An
overview of some of the research projects currently underway in GGEPL is
given below. We run both baseline surveys and monitoring activities in
addition to projects that are investigating threats to specific species from
defined pathogens. The results are used to provide guidance on disease
management issues for the Galapagos National Park and other conservation
organisations in the islands.
The laboratory also acts as a resource for other scientific research in the
archipelago by providing facilities for visiting scientists involved in
other projects. More information about how to develop research links with
the lab is here.
Baseline surveys and monitoring of pathogens in the Galapagos ecosystem
At present, although some wildlife disease research has
been carried out by Charles Darwin Research Station and other visiting
international scientists, there is still much we do not know about the
distribution, abundance and impact of pathogens that affect Galapagos
fauna. In order to be able to devise wildlife disease management plans
and assess future change that may arise from new disease introduction or
climate change, we need to get a current picture of both native and
introduced pathogens that are present in the archipelago. The GGEPL team
uses a range of molecular and pathology techniques (such microscopic
analysis and detection of antibodies) to examine material from regular
surveys of live animals, and opportunistic necropsies of animals that
are found dead. We are also investigating the diseases that are
harboured by many domestic and introduced species, that threaten to
spill over in to the wild populations.
Many of the pathogens found in Galapagos are new, haven't been studied
before with molecular techniques, or are slightly different from
mainland forms requiring adaptation of existing methods. Therefore, many
new molecular tools have to be developed by the project. GGEPL scientists have established
a number of sensitive, mostly PCR based assays designed to monitor
wildlife diseases in the endemic species of the archipelago.
The
laboratory also uses a range of other techniques for pathology
investigations including histology, serology, haematology and
bacteriology.
Pathogens carried by domestic animals, are
sometimes capable of being transmitted to wild species. For example, the
Canine Distemper Virus (CDV) which occurs in domestic dogs, can infect
and kill a large range of carnivores including pinniped (seal) species.
CDV was responsible for the widespread extinction of the wild dog from
large areas of sub-Saharan Africa. CDV was also responsible for causing
the massive die-off of thousands of Caspian seals (now a IUCN vunerable
species) in 2000; (see article by
Kennedy et al.,
2000) and for a mass mortality among seals in lake Baikal, Russia. On
the Galapagos Islands, outbreaks of Canine distemper have occurred
amongst domestic dogs in the major population centres. Native sealions
and fur seals in Galapagos could be at risk of CDV and other pathogens
circulating in domestic carnivores, because they frequently come into
contact. GGEPL scientists have initiated a survey of the exposure to
such viruses amongst the sealion and fur seal populations. In addition,
we are working with WildAid to monitor the prevelance of key pathogens
in domestic dogs and cats that present threats to endemic wildlife.
West Nile Virus (WNV) has
recently emerged as a potent threat to New World biodiversity. The virus
infects a wide range of host species: birds, mammals (including man) and
reptiles are all suscepitible to infection which is largely transmitted
through intermediate vectors, notably biting insects such as mosquitoes.
To date the virus has been shown to infect over 280 bird species and a
variety of mammalian and reptile hosts. Since arriving on the Eastern
continental US in 1999, WNV has since spread inexorably South and West,
reaching Central America and the Caribbean by 2003 and becoming
established on the West Coast of the US by 2004. The virus was
responsible for widespread regional die-offs amongst birds in the US,
has killed large numbers of other animals and caused human casualties
(284 in 2002). The virus could reach continental Ecuador within 2 years,
at which point it poses an acute threat to the islands unique fauna
unless strict precautionary measures are taken. A risk assessment
presented at our
West Nile Virus Workshop,
suggests that by far, the greatest threat of WNV introduction to the
islands comes from mosquitoes arriving on passenger aircraft, with
smaller risks coming from sea cargo and migrating birds.
In 1996 Park Staff
patrolling the highlands of Santa Cruz, observed a number of tortoises
dying from a mystery ailment. Similar symptoms and deaths have recurred
within the giant tortoise population in that area in subsequent years,
particularly during the colder periods. The causative agent of these
deaths still remains to be identified. Veterinary staff from GGEPL, (in
collaboration with colleagues from the CDRS) have begun the
systematic monitoring the tortoise population in the Santa Cruz
highlands. Samples from both symptomatic and healthy individuals in the
area are being tested in the GGEPL laboratory for the presence of
candidate pathogens.
One of the key ways in which
pathogens and parasites are transmitted is through biting arthropod
vectors such as mosquitoes and ticks. Native vector species may transmit
pathogens that occur naturally in Galapagos but may also be able to
transmit novel diseases should they be introduced. Several potential
vector species have been introduced to the islands that could alter the
transmission of existing wildlife diseases or act as vectors for new
introduced pathogens.
GGEPL scientists are
currently evaluating the distribution and abundance of the known West Nile Virus
(WNV) vector mosquito species in Galapagos. This will help in
understanding the potential impacts of WNV and suggest possible control
strategies. We are also using genetic techniques to analyse mosquito blood meals to determine feeding
patterns on endemic Galápagos species, and what parasites they may be
transmitting.
GGEPL is a partnership
between Galápagos National Park; the School of Biology, University of Leeds
UK, the Institute of Zoology, Zoological Society of London; and the
University of Guayaquil. The funding for this project is provided through
the UK government's Darwin Initiative scheme (Grant number 162-12-017).
Updated 21st September 2005 by Simon Goodman
(c) GGEPL 2005