Faculty of Biological Sciences

Pre-clinical Imaging at the University of Leeds

Biomedical imaging plays a central role in understanding physiological and pathological processes at the molecular, cellular, tissue and whole organism level. At the University of Leeds, biomedical researchers have access to a growing range of state of the art imaging modalities to facilitate cutting edge basic and translational research. This page provides an overview of preclinical imaging modalities available at the University of Leeds. Click on any of the images below for more details.

Imaging facilities

A range of pre-clinical imaging is available including high resolution ultrasound, in vivo fluorescence imaging and pre-clinical image guided radiotherapy using SAARP.

In vivo fluorescence imaging with IVIS Spectrum Pre-clinical guided radiotherapy with SAARP VisualSonics Vevo 770 Ultrasound
The IVIS® Spectrum in vivo imaging system uses a novel optical imaging of fluorescent or bioluminescent reporters to facilitate noninvasive longitudinal monitoring of disease progression, cell trafficking and gene expression patterns in living animals. The IVIS Spectrum is a versatile and advanced in vivo imaging system. SARRP incorporates CT imaging with precise radiation delivery to enable researchers to pinpoint an exact anatomical target and confidently deliver 0.5 mm beams to that point. This small animal irradiator can then deliver single or multiple beams of radiation to the target with the upmost accuracy, matching the clinical techniques used in oncology departments around the world. VisualSonics Vevo 770 imaging system uses micro-ultrasound to generate high-resolution (down to 30 micrometers) images.

Pre-clinical imaging facilities are currently being reconfigured with the development of a new Centre for Translational Cardiovascular Imaging. Funded jointly by the University of Leeds and a Strategic Infrastructure Grant from the British Heart Foundation (Principal Investigator Professor Sven Plein) the new facility will bring together a range of state of the art imaging modalities.

Multiphoton microscope

Multiphoton microscope (LIGHT building)

Multiphoton microscopy achieves resolution similar to confocal microspcopy with greater sample penetration. These properties enable high quality physiological and pathophysiological studies at micrometer resolution in tissues in vitro and in vivo.
Contact: David Myers d.s.myers@leeds.ac.uk

Vevo 2100 ultrasound system (CBS)

Vevo 2100 ultrasound system (CBS)

The VisualSonics Vevo 2100 is a state of the art, high frequency, high resolution pre-clinical ultrasound system suitable for a wide range of applications.
Contact: Nadira Yuldasheva n.yuldasheva@leeds.ac.uk

Brucker Biospec preclinical MRI

Brucker Biospec preclinicalMRI

A Brucker Biospec 70/20 MRI scanner will be housed within the new Centre for Translational Cardiovascular Imaging. MRI enables the quantitative or semi-quantitative in vivo assessment of cardiac anatomy, myocardial function and perfusion, tissue characterisation and metabolism.

Laser Doppler Imaging (CBS)

Laser Doppler Imaging (CBS)

The Moor Instruments LD12-HIR is a laser doppler imaging system optimised for blood flow (angiogenesis) studies but suitable for a range of other applications.
Contact: Nadira Yuldasheva n.yuldasheva@leeds.ac.uk

Murine In Vivo Imaging Platform

Murine In Vivo Imaging Platform

A Brucker Albira multi-modality imaging system will be housed within the new Centre for Translational Cardiovascular Imaging. Combining PET, SPECT and CT in a unique way the Albira provides an extremely powerful tool for preclinical research.